Comparative Study of Vitamin D Deficiency between PCOD and Normal Women: A Prospective Hospital Based Study
Background: - Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, with a prevalence of 6–10% in the general population. PCOS is characterized by the following: ovulatory dysfunction resulting in oligo-amenorrhea and/or anovulation, hyperandrogenism and/or hirsutism and the presence of polycystic ovarian morphology by ultrasound. Vitamin D also plays a physiologic role in reproduction including ovarian follicular development and luteinization via altering anti- Müllerian hormone (AMH), signaling, follicle- stimulating hormone sensitivity and progesterone production in human granulosa cells. The aim of this study aimed to compare levels of vitamin D in women with PCOS and normal women. Methodology: - Total fifty women were included in this study. Among the fifty cases 50% were from PCOD group and 50% were normal. This study were conducted in the Dept. of Obs/Gynae, Madhubani Medical College, Bihar. Blood sample was taken and serum vitamin D concentration was measured.
Result: - Mean serum 25(OH) vitamin-D level in PCOD group and in control group is clinically significant.
Conclusion: - This study concludes that 25(OH) vitamin-D was clinically significant, but not sufficient to be a diagnostic tool for PCOS.
2. Haoula Z, Salman M and Atiomo W (2012): Evaluating the association between endometrial cancer and polycystic ovary syndrome. Hum. Reprod., 27:1327-1331.
3. Hahn, S., et al., Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes, 2006. 114(10): p. 577-83.
4. Yildizhan, R., et al., Serum 25-hydroxyvitamin D concentrations in obese and non-obese women .
5. Studzinski G, McLane J and Uskokovic M (1993): Signaling pathways for vitamin D-induced differentiation: implications for therapy of proliferative and neoplastic diseases. Crit. Rev. Eukaryot. Gene Expr.,3:279-312.
6. Irani M and Merhi Z (2014): Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil. Steril., 102: 460-469.
7. Alvarez J and Ashraf A (2010): Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis. Int. J. Endocrinol., 2010:351-385.
8. Parikh G, Varadinova M, Suwandhi P et al. (2010): Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells. Hormone and Metabolic Research,42: 754–757.
9. Lips P (2010): Worldwide status of vitamin D nutrition. J .Steroid .Biochem Mol. Biol.,121:297-300.
10. Holick, M.F., Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr, 2004. 80(6 Suppl): p. 1678S-88S.
11. Mahmoudi, T., Gourabi, H., Ashrafi, M. et al. (2010) Calciotropichormones, insulin
resistance, and the polycystic ovary syndrome.Fertility and Sterility, 93, 1208–1214.
12. Vitamin D Levels in Women with Polycysticovary Syndrome Elida Sidabutar1,
Binarwan Halim2, Muhammad Fidel Ganis Siregar, DelfiLutan,-6 th congress ASPIRE
13. Wehr, E., Trummer, O., Giuliani, A. et al. (2011) Vitamin Dassociatedpolymorphisms
are related to insulin resistance andvitamin D deficiency in polycystic ovary syndrome.
EuropeanJournal of Endocrinology, 164, 741–749
14. Ashraf Moini ET AL -Comparison of 25-hydroxyvitamin D and CalciumLevels
between Polycystic Ovarian Syndrome and Normal Women int J Fertil Steril 2015 Apriljune
15. Li, H.W.R., Brereton, R.E., Anderson, R.A. et al. (2011) Vitamin D deficiency is
common and associated with metabolic risk factorsin patients with polycystic ovary
syndrome. Metabolism:Clinical and Experimental, 60, 1475–1481
16. Hanif fauzia et al. vitamin d level in unmarried female with pcod, JIIMC(2016.)
17. Hahn S, Haselhorst U, Tan S, Quadbeck B, Schmidt M Roesler S, et al. Low serum 25-
hydroxyvitamin D concentrations are associated with insulin resistance and obesity in
women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes. 2006; 114(10):
18. Ashiem ET, Hofso D, Hjelmesaeth J, Birkeland KI, Bohm-er T. Vitamin status inmorbidly obese patients: a cross sectional study. Am J Clin Nutr. 2008; 87(2): 362-36