International Archives of BioMedical and Clinical Research <p style="text-align: justify;"><sup>International Archives of Biomedical and Clinical Research (IABCR) is an open access, international, peer-reviewed, quarterly multidisciplinary medical research journal that focuses on communicating high quality research articles, reviews, Short communications, case reports, Letter to Editor, Drug News and updates in the field of Medical, Dental and other allied health and BioMedical Sciences. The Journal publishes 4-four issues in a year.</sup></p> <h3><sup>Connecting Researchers Globally</sup></h3> <p style="text-align: justify;"><sup>IABCR offer Researchers, Academicians a better option when it comes to Open Access Journal publishing. Our platform vies to become the standard for all open access publications, irrespective of subjects or branches and aims to bring together researchers from all over the world and under a single global organization to form a community that actively creates new data and shares it with everyone with the utmost ease and simplicity.</sup></p> <h3><sup>Ethical guidelines for journal publication</sup></h3> <p style="text-align: justify;"><sup>The Editor-in-Chief/Editor of International Archives of BioMedical and Clinical Research (IABCR) is responsible for determining which of the research papers/articles submitted to the journal should be printed. The publication decision is based on the recommendation of the journal's reviewers. The Editor-in-Chief /Editor may be maneuvered by the policies of the journal's editorial board and constrained by such legal requirements as shall then be in force regarding libel, copyright infringement and plagiarism. The Editor-in-Chief/Editor may consult with other editors or reviewers in getting to this determination.</sup></p> en-US (Dr. Farhan Ahmad Khan, MD) (Mohd Waseem) Thu, 21 Mar 2019 20:27:19 +0000 OJS 60 Role of Beta HCG and AFP in Prediction of Hypertensive Disorder in Pregnancy in Second Trimester- A Hospital Based Prospective Study <div class="page" title="Page 1"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Background: Pre-eclampsia is an important cause of maternal and neonatal complication and death. If hypertension in pregnancy is diagnosed at an early age, we can provide an efficient care to mother for good outcome of pregnancy. The aim of this study to evaluated the role of B-HCG and AFP as predictors of HDP.</p> <p>Methods: This prospective Investigation study was conducted on 100 pregnant women attending the antenatal clinic in Department of Obstetrics and Gynaecology, Jaipur. Estimation of serum β-HCG and AFP was done by ELISA technique. Then there finding were correlated with the value of serum β-HCG and AFP in second trimester to see whether there is any relation between levels of serum β- HCG and AFP in second trimester and development of HDP.</p> <p>Results: ‘Out of 100 women, 5 i.e. 5% were &lt;20 years of age, maximum i.e. 62 (62%) were in 21-25 years of age group, 25 (25%) were in 26-30 years of age group and 8 (8%) were in 31-35 years age of group. Significantly higher mean S. β-HCG (mIU/ml) was observed in HDP group i.e. 13450.5±3420.8 as compared to 7732±2024 in normotensive group and a test of full model was statistically significant indicating that the predictors reliably distinguish between HDP group and normotensive group (Chi square 55.328, df 4, p&lt;.001).</p> <p>Conclusion: We conclude from this study the measurement of serum β-HCG and AFP should be routinely done in second trimester of pregnancy, to predict the occurrence of HDP for better fetomaternal outcome.</p> </div> </div> </div> </div> Lata Rajoria, Megha Agarwal, Praveena Choudhary, Charusmita ., Girija ., Teena . ##submission.copyrightStatement## Thu, 21 Mar 2019 05:56:24 +0000 Epidemiological Study of Host Factors Responsible for Tinea Cruris Infection & Clinical Resistance to Treatment <div class="page" title="Page 1"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Background: Superficial fungal infection are most common fungal infection affecting 20 -25% of population living in tropical and subtropical countries. Global warming, rapid industrialization, migration of population and changing lifestyle are contributory factors.</p> <p>Aim: To study the host factors responsible for Tinea cruris infection and clinical resistance to treatment.</p> <p>Methods: Hundred patients of tinea cruris were taken for study and data regarding age, occupation, income, education and prior treatment taken was collected. Modified Kupuswamy scale 2017 was applied for socioeconomic status.</p> <p>Results: ‘Majority of patients were males (85%). Young adults (20-40 years) with low socioeconomic status were predominantly affected. Application of steroids and poor compliance to treatment were contributory factors in development of clinical resistance to treatment.</p> <p>Conclusion: By improving working environment and socioeconomic status, mass awareness, proper counseling we can restrain the ongoing epidemic of dermatophytes infection.</p> </div> </div> </div> </div> Shanta Passi, Namrata Kahlon, Deepika Uikey ##submission.copyrightStatement## Thu, 21 Mar 2019 06:02:18 +0000 Occurrence of De Quervain’s Tenosynovitis and its association with Short Message Service Texting Habit: A cross-sectional Study in the General Population of Karachi, Pakistan <div class="page" title="Page 1"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Background: To determine the frequency of De Quervain’s tenosynovitis and its association with Short Message Service (SMS texting).<br>Methods: A cross sectional study was conducted to determine the prevalence of De Quervain’s tenosynovitis in the general population of Karachi, ranging in age from 15-35 years with a sample size of 700 individuals. Participants from different educational backgrounds were included. De Quervain’s tenosynovitis was diagnosed through Finkelstein test. Data entry and analysis were done through SPSS version 20.0. Chi-squared test with 95% confidence interval was applied to compare categorical variables, P value &lt; 0.05 was considered significant. Results: Male to female ratio was 1:2. A total of 79.3% were undergraduates or below in academic qualification. The education level and the median age were consistent with our target population. An overwhelming majority of 96.7% (678) use touch screen smart phones. Hardly anyone uses standard cell phones (0.7%) or QWERTY keyboard cell phones (1.4%). 1.1% of responders had cell phones of some other type. “Internet Usage” was the most frequent answer on the purpose of using cell phones with 91.6% (642). The next frequent answer was “Texting” with 85.6% of responders. 126 people had other uses for their cellphones apart from internet, texting, calling, reading, or playing games. 58.8% (412) of the 700 responders tested “positive” for the Finkelstein test, demonstrating pain in the wrist and thumb while performing the maneuver.</p> <p>Conclusion: The result of our study concluded that a significant majority of our youth uses touch screen smartphones, weighing an average of 100g, mainly for internet usage and texting. Because of the overuse of thumb musculature, more than half of them experienced pain over the radial side of the wrist and got a positive Finkelstein test which shows there is a positive relationship between De Quervain's and frequent and prolonged smartphone usage. Having a positive result for the Finkelstein test could lead to severe De Quervain's tenosynovitis.</p> </div> </div> </div> </div> Naseem Ahmed, Hafiz Yahya Iftikhar, Rabiya Javed, Tahniat Warda, Samra Samad ##submission.copyrightStatement## Thu, 21 Mar 2019 18:48:57 +0000 Screening of Gestational Diabetes among Women Visiting Metabolic Clinic in the Department of Biochemistry of a Medical College in Eastern U.P <div class="page" title="Page 1"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Background: Gestational diabetes mellitus (GDM) is a diabetic metabolic disorder that occurs in 4% of all pregnant women and 14% of ethnic groups with more prevalence of type II diabetes. It can be defined as increased or abnormal insulin resistance, decreased insulin sensitivity or glucose intolerance with first diagnosis during pregnancy. Aims/Objectives: 1. To find out prevalence of GDM. 2. To study associated risk factors.</p> <p>Methods: The study was conducted at the metabolic clinic; in the department of Biochemistry located at SIMS, Hapur. A semi-structured pretested questionnaire was used for data collection. Following the DIPSI guidelines, patients with plasma glucose values &gt;140 mg/dl were labeled as GDM. Statistical methods used were OR (CI95%), percentage, Chi square.</p> <p>Results: ‘Out of 500, 6.72% had GDM. Among all GDM patients, 64.71% had age more than 30 years, 70.59% had BMI more than 25, 41.18% had gravida more than 3 and p- value was significant with regard to age and BMI. P value was found to be significant for risk factors namely positive family history of Diabetes Mellitus, history of big baby and presence of more than one risk factor.</p> <p>Conclusion: GDM is associated with high BMI, early pregnancy loss, family history of DM and previous history of big baby and there could be more than one risk factor. Thus universal screening followed by close monitoring of the pregnant women for early detection of GDM may help improving maternal and fetal outcomes.</p> </div> </div> </div> </div> Vivek Sinha, Poonam Kachhawa ##submission.copyrightStatement## Thu, 21 Mar 2019 00:00:00 +0000 Assessment of Prevalence of Fractures Among Children of Known Population: An Observational Study <div class="page" title="Page 1"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Background: The incidence of bone fracture is impacted by many factors including age and gender. Every third child is expected to sustain a fracture before age 17. Hence; we assessed the prevalence of fractures among children of known population.<br>Methods: A total of 100 patients who reported with bone fracture were included in the present study. Complete demographic details of all the patients were obtained. Detailed information in relation to the pattern and type of injury was also obtained. All the results were recorded in Microsoft excel sheet and were analyzed. Results: There were 63 males and 37 females. Incidence of fractures was significantly higher in males in comparison to females. Radius was the most common bone to be fractures, found to be present in 27 males and 15 females.</p> <p>Conclusion: Fractures among pediatric population are significantly more common in males, with radius being the most common bone to be fractures.</p> </div> </div> </div> </div> Ashok Kumar, Prashant Garhwal ##submission.copyrightStatement## Thu, 21 Mar 2019 18:57:07 +0000 A Prospective Study on Prevalence of Hyperprolactinemia & Hypothyroidism in Benign Breast Diseases <div class="page" title="Page 1"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Background: Benign breast disorders are usually come across in Indian clinical practice. Due to Cultural inhibitions many Indian women don’t turn up for breast related problem. Therefore, they are unaware of the breast changes that usually occur, and these changes may be normal or abnormal. Methods: Fifty cases were included in this study on the bases of clinical symptoms. This study conducted in the department of surgery, Madhubani Medical College, Bihar. The duration was study was six months. Data were collected on the bases of clinical symptoms &amp; serum was collected for the estimation of TSH &amp; prolactin.</p> <p>Results: ‘Prevalence of serum prolactin &amp; TSH estimation done for all the patients and revealed that 22% cases had hyperprolactinemia &amp; 24% had thyroids.<br>Conclusion: The results of our study conclude that strengthen the association of thyroid dysfunction with benign breast disease.</p> </div> </div> </div> </div> Mohd Tarique ##submission.copyrightStatement## Thu, 21 Mar 2019 19:01:48 +0000 Role of Calcium Toxicity in Neurodegenerative Diseases <div class="page" title="Page 1"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Background: Neurodegenerative diseases are those affect the central nervous system (brain, spinal cord) and peripheral nervous system. It is characterized by progressive loss of neurons and synapses in these nervous systems. Calcium homeostasis receives key attention in the past few years in the field of neuronal physiology of Ageing and Neurodegenerative diseases.</p> <p>Objective: The aim of this study was to evaluate Calcium homeostasis in patients with Neurodegenerative diseases.<br>Methods: 50 subjects (36 males and 14females) with Neurodegenerative diseases. And same number of healthy age-matched subject control group was assessed. A complete &amp; detailed neurological examination were performed in all individuals and clinically evaluated for the occurrence of Neurodegenerative diseases. Calcium levels were estimated using (Instrumentation Laboratory – IlyteTM) Automated Electrolyte Analyzer, with solution pack and reagents.</p> <p>Results: ‘The Serum Calcium (Ca2+) levels were estimated and comparison was done in both control and case group separately, for evaluating the changes due to ageing and in particular to neurodegenerative diseases.<br>Conclusion: Neurodegenerative diseases showed significant differences in Calcium homeostasis.</p> </div> </div> </div> </div> Anjum Mirza Chughtai, Nisar G Ahmed, D K Agrawal, Sangeeta Singhal ##submission.copyrightStatement## Thu, 21 Mar 2019 19:07:48 +0000 Molecular Subtypes of Breast Cancer According to Immunohistochemical Expression of Hormone Receptors in A Region of North West India: A Comparative Study with Other Regions in India and Around the Globe <div class="page" title="Page 1"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Background: Breast cancers have been subclassified on the basis of molecular expression. This study evaluates the receptor expression in breast carcinoma by immunohistochemistry and classifies them into various subtypes. A comparison with other regions was also made.<br>Methods: This prospective study included all the patients of breast carcinoma who had undergone the surgical treatment of mastectomy at SMSMC from January 2014 to June 2017. Immunohistochemical expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) was studied and subtypes were determined. Comparison of the receptor expression and patterns was done in different age groups and with other regions. Results: ‘A total of 496 cases were included in this study. The mean age at diagnosis was 48.2 years. Most of the patients (60.3%) were less than 50 years old whereas 39.7% were above 50 years. By Bloom Richardson scoring 28.7%, 56.8% and 14.5% tumours were classified as Grade I, Grade II and Grade III respectively. ER, PR and HER2neu receptor positivity was seen in 57.5%, 44.1% and 26.6% respectively. The most common molecular subtype was luminal A (41.7%) followed by triple negative subtype (30.8%). Luminal B and HER2neu overexpressing types were 15% and 12.5% respectively.</p> <p>Conclusion: Immunohistochemical markers act as surrogate markers for molecular classification of breast cancers. Hormone receptor expression at our institute was comparable with other studies from India. Luminal A is the most common occurring subtype of breast cancer presenting at our institute.</p> </div> </div> </div> </div> Maryem Ansari, Alka Mittal, Jayanti Mehta, Niharika Jain ##submission.copyrightStatement## Thu, 21 Mar 2019 19:13:19 +0000 A Comparative Evaluation of Rapid Card Test with Enzyme- Linked Immunosorbent Assay for the Detection of HBsAg Among Pregnant Women in a Tertiary Care Hospital <div class="page" title="Page 1"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Background: Hepatitis B virus infection is an important health problem and a leading cause of death worldwide. The most important marker for HBV infection is HBsAg. A proper identification of kit is required for proper diagnosis of infection, as well as disease management and prevention. Aims&amp; Objective: - The aim of the present study was to compare rapid HBsAg detection ICT kits for the screening of HBV infection with gold standard ELISA method.</p> <p>Methods: The study comprised 500 blood samples of pregnant women. These samples were tested with ICT kits of (Hepa Card Company) and ELISA (HEPLISA by J. Mitra.). Results: In present study we found 100% sensitivity, 99.59% specificity, 81.81% positive predictive value ,100%Negative predictive value and 99.60% diagnostic efficiency of rapid card test with comparison to ELISA for HBsAg detection. Conclusion: The present study concluded that the overall performance of the rapid ICT kit for HBsAg was equally sensitive to ELISA and yet they were cheap and quicker. It can be recommended that ELISA comparable rapid devices may be allowed to be used for preliminary screening of HBsAg especially in remote areas or where cost is an issue.</p> </div> </div> </div> </div> Megha Sharma, Saroj Golia, S K Mehra, Manoj V Jani ##submission.copyrightStatement## Thu, 21 Mar 2019 19:19:34 +0000 Effectiveness of medicine Malaria Off 200 as mass prophylaxis against Malaria in the high-risk villages of Shahdol, Madhya Pradesh <p><strong>Background: </strong>Learning from the past experiences, the district health authority Shahdol has planned a <em>mass-prophylactic</em> activity with the Homeopathy Medicine (<em>Malaria Off 200</em>) in the selected high-risk villages (above 5 API) in the year 2016</p> <p><strong>Objective: </strong>The present paper reports the effectiveness of <em>Malaria off 200 </em>as <em>mass-prophylactic </em>drug in addition to routine antimalarial activities under NVBDCP in district Shahdol, Madhya pradesh in year 2016.</p> <p><strong>Methodology:</strong> A Homeopathic drug <em>Malaria Off 200</em> was used for the <em>mass-prophylaxis</em> of&nbsp; Malaria in high malaria transmission season in selected 28 villages of district Shahdol. The effectiveness of the drug was ascertained as <em>“Reduction of </em><em>≥20% villages, having more than 2 malaria case in six-month period </em><em>(July-December 2016)</em><em>in comparison to the previous year”.</em></p> <p><strong>Result: </strong>Of the 28 villages, seven (25%) reported Malaria case&nbsp; incidence equal to or less than two in <em>six-month period </em><em>(July-December 2016)</em>. In the same time period in previous year 23 (82%) villages reported Malaria case&nbsp; incidence more than two. So, reduction of number of villages with 'biannual Malaria case&nbsp; incidence’ rate was 57%.</p> <p><strong>Conclusion:</strong> The short term finding validate the campaign as <em>effective, </em>as per the operational definition of <em>effectiveness </em>coined for the campaign. However, further time series studies with Autoregressive Integrated Moving Average (ARIMA) is recommended for future.</p> Rajesh Pandey, MS, (General Surgery), Sanjay Gupta, MD (Hom), Akash Ranjan Singh, Juhi Gupta, MD (Hom.), Vikrant Kabirpanthi, MD (Community Medicine) ##submission.copyrightStatement## Thu, 21 Mar 2019 19:27:05 +0000 Comparative Study of Ultrasound Therapy and Pulsed Electromagnetic Field (PEMF) Therapy in Cases of Tennis Elbow <div class="page" title="Page 1"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Background: Tennis elbow is a syndrome of insidious onset with tenderness, pain in movement and decline in grip strength. Pulsed Electromagnetic Therapy (PEMF) and ultrasonic therapies (U.S. therapies) are proving adjuncts for enhancing fracture healing, reducing inflammation and symptom relief to varied extent in different reports. The benefit of two therapy regimens in tennis elbow is comparatively evaluated in patient of our region.</p> <p>Methods: 60 patients sequentially enrolled following informed consent were administered either PEMF or ultrasound therapy daily for 6 weeks. Parameters examined were pain score, pressure pain threshold (PPT) and pain free grip strength (PFGS).<br>. Results: It was found that either of the therapies PEMF and U.S.therapy significantly improved the three tested parameters. The relative improvement in pain score between two treatment groups did not significantly differ. PEMF give significantly higher gain in PPT and very marked gain in PFGS as compared to U.S. therapy.</p> <p>Conclusion: PEMF therapy was found to yield significantly superior relief than ultrasound therapy in patient of lateral epicondylitis with respect to pain, pressure pain threshold (PPT) and pain free grip strength (PFGS). Improvement in pain score was similar in two groups.</p> </div> </div> </div> </div> Anuja Pasari ##submission.copyrightStatement## Thu, 21 Mar 2019 19:36:47 +0000 Feedback of Second-Year Medical Students on Existing Teaching Methodology in Pharmacology: A Questionnaire Based Study <div class="page" title="Page 1"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Background: In order to successfully run a curriculum in a medical college, it is a mandatory to collect regular feedback from the students regarding teaching and learning methodologies. The primary objective of our study was to analyse the various teaching-learning aids and course content of pharmacology. The secondary objective was evaluation of pharmacology practical classes and their relevance in relation to the interests of students as well as clinical application.</p> <p>Methods: This is a cross sectional, open labelled questionnaire based study conducted among 100 2nd year MBBS students of a tertiary care teaching hospital. The questionnaire consisted of 10 questions with 4 response options each. Descriptive statistics was used for analysis and interpretation and the results were expressed as percentage frequency of responses. Results: It was revealed from our study that a majority of the students (45%) found microbiology undergraduate practical laboratory more interesting with pharmacology at 35%, which reflects that 65% students think that pharmacology laboratory exercises are boring and less useful. From among the pharmacology practical laboratories (clinical laboratory, experimental pharmacology and pharmacy), majority (47%) of the students opted for clinical prescription and problem based learning exercises as most beneficial. A whopping 55/100 students wanted introduction of clinical case studies as part of the regular practical teaching schedule while 30 students felt that doctor-patient role play should be included in teaching curriculum for better understanding of subject. Surprisingly, 42% of students find audio visual aids as most useful teaching methodologies while 33% students like bilateral (student- teacher) interactive classes. On the contrary, 72% of the students prefer studying pharmacology from combination of both lecture notes, textbooks and their self-prepared notes. 50/100 students wanted inclusion of more case studies and treatment protocols as a part of regular teaching protocol in pharmacology and 30 students wanted more group discussions to be included as a part of teaching curriculum in pharmacology. Conclusion: Pharmacology is a dynamic and continuously evolving branch of medicine. The results of our study are hoped to help in knowing students’ perspective regarding pharmacology teaching and modifying pharmacology teaching patterns for better outcomes.</p> </div> </div> </div> </div> Sana Alam, Zenis Baluja, Nusrat Nabi ##submission.copyrightStatement## Thu, 21 Mar 2019 19:45:38 +0000 Spectrum and Pattern of Paediatric Dermatoses in A Tertiary Care Hospital in Faridabad <div class="page" title="Page 1"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Background: The prevalence of paediatric skin diseases varies worldwide. Paediatric dermatoses require a separate view from adult dermatoses as there are important differences in clinical presentation, treatment and prognosis. Their characterisation is essential for the preparation of academic, research and health plans.</p> <p>Aim: The study was carried out to find the incidence of skin diseases in children under 15 years of age.<br>Methods: All children below 15 years of age attending dermatology outpatient department for first time were evaluated for various skin dermatoses. Skin diseases were classified into groups like infections and infestations, eczematous, non-infective dermatoses and hypersensitivity reactions. Results: Male children predominated with male female ratio 1.3:1. Infections and infestations were the most common (41.8%) cause of skin dermatoses followed by dermatitis (20.7%), non-infective &amp; autoimmune dermatoses (13.4%) and hypersensitivity reactions seen in 10.8% patients. Miliaria and other physical dermatoses contributed to about 6% of the total cases.</p> <p>Conclusion: Majority of paediatric dermatoses can be grouped into 8 categories. Significant proportion of dermatoses are infectious and eczematous types. Infections are more prevalent in low socio-economic strata and with proper education and creating awareness they can be minimised to a significant extent.</p> </div> </div> </div> </div> Shanta Passi, Kumar Himanshu, Sneh Lata ##submission.copyrightStatement## Thu, 21 Mar 2019 20:00:05 +0000 Serum Analysis of Hydro-pericardium Syndrome (HPS) by Filter-Paper Blood Sampling Technique: As Substitute to Serum Collection Technique <div class="page" title="Page 1"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Background: The study aimed to assess the filter paper blood sampling technique for sero- monitoring against Hydro-pericardium syndrome (HPS). In view of the fact, dried blood samples don’t require immediate refrigeration, occupy little space and are easily transported.<br>Methods: Whole blood paired with serum samples were collected from 100 broiler chickens on filter paper strips, dried for 2hrs at 37oC, stored in polythene bag and then eluated in normal saline at 4oC for overnight. Antigen of HPS was isolated, purified and confirmed by agar gel precipitation test (AGPT) with raised hyper-immune serum. Eluates of whole blood dried on filter paper with corresponding serum samples were tested for antibody activity by indirect heam-agglutination (IHA) test. Results: ‘The IHA titers of eluates were similar to titers obtained with serum diluted as 1:10. Normal saline and phosphate buffered saline did not influence the antibody stability, when used as eluating fluid. Whole blood dried on filter paper could be stored sealed in plastic bag at 4oC or ambient temperature for at least one week with no appreciable loss of antibody titers. A strong correlation (r = 0.900) exist between the titers obtained with two methods of blood sampling.</p> <p>Conclusion: This study demonstrated that recovery of antibodies from blood dried on filter paper after eluation produces results comparable to those obtained by recovering antibodies from serum. Based on above findings it is concluded that filter paper blood sampling could serve as a cost effective and convenient tool for HPS sero-monitoring.</p> </div> </div> </div> </div> Abdul Razak, Iftikhar Hussain, Rehan Rafique, Sajid Hussain, Muhammed Shoaib Noor, Asaad Nayyer ##submission.copyrightStatement## Thu, 21 Mar 2019 20:09:08 +0000 An Adolescent Female Presenting with Classical Clinical and Immunological Features of Isoniazid Induced Lupus <p>Drug induced Lupus Erythematosus (DILE) is a form of rare adverse drug reaction caused due to many drugs, including Isoniazid. Diagnosis is made on the basis of a temporal relationship between the drug administered and the onset of symptoms and on the basis of the antibody profile. We describe the case of a 13 year old female who was diagnosed as having abdominal tuberculosis and was put on ATT and later presented with signs and symptoms of Lupus Erythematosus, with a history of photosensitivity, oral ulcers, and malar rash.</p> <p>Keywords: Isoniazid, Tuberculosis, Drug Induced Lupus</p> Kumar Himanshu, Deepika Uikey ##submission.copyrightStatement## Thu, 21 Mar 2019 20:15:56 +0000 Prosthetic Rehabilitation in a Child with Hereditary Ectodermal Dysplasia <div class="page" title="Page 1"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Hereditary ectodermal dysplasia is a disease linked to the X recessive chromosome that affects the development of tissues derived from the ectoderm. The main clinical manifestations include hypohidrosis (inability to sweat), hypotrichosis (sparse hair) and hypodontia (lack teeth). This work presents a clinical case of a 6-year old male child who had been diagnosed with hereditary ectodermal dysplasia. The treatment consisted of the fabrication of a mandibular and maxillary complete denture to improve his esthetic, functional and psychological conditions.</p> </div> </div> </div> </div> Carlos Henrique R Nunes, Mariana Campello Nunes, Aristides da Rosa Pinheiro, Cleonicio Cordeiro Filho, Bruno Cunha Rangel, Ricardo Villas-Bôas, Carlos Fernando de Almeida Barros Mourão, Priscila Ladeira Casado ##submission.copyrightStatement## Thu, 21 Mar 2019 20:22:05 +0000