A Prospective Study on Serum Uric Acid Level in Predicting Outcome in Acute Myocardial Infarction
DOI:
https://doi.org/10.21276/p7983x83Keywords:
Acute myocardial infraction, Uric acid, STEMIAbstract
Background: Higher levels of SUA are also associated with hypertension and renal disease. It is observed in >75% of patients with malignant hypertension. This elevation has been reported as a result of decreased renal blood flow and resultant increased urate reabsorption. It has been further reported that a 1 mg/dL increase in SUA levels was associated with a 26% increase in mortality.
Methods: . The duration of study was over a period of two year. Total 204 cases were included with acute myocardial infraction. This study was conducted in the Department of Medicine.
Results: In this study 204 cases of acute myocardial infraction were included. Among all cases 132 were male & 72 were female. Prevalence of uric acid level in acute MI cases were 4.1-5.5 mg/dl seen in 28.4% followed by >7.0 mg/dl in 27.4%, <4 mg/dl in 22.5% & 5.6-7.0 mg/dl in 21.5%.
Conclusions: This study concludes that serum uric acid is a cheap and effective prognostic indicator of AMI.
Downloads
References
Sethi KK, ed "Preface" in Coronary Artery Disease in Indians. A Global Prospective 1998: 9 pp.
Alderman M, Alyer KJ. Uric acid: role in cardiovascular disease and effects of losartan. Curr Med Res Opin 2004; 20: 369-79.
Deniell.Feig, Duk-Hee Kang et.al. Uric acid and Cardiovascular Risk, The New England Journal of Medicine, October 23, 2008.
Anker SD, Doehner W, Rauchhaus M, et al. Uric acid and survival in chronic heart failure: Validation and application in metabolic, functional, and hemodynamic staging. Circulation 2003;107:1991-7.
Leyva F, Anker S, Swan JW, et al. Serum uric acid as an index of impaired oxidative metabolism in chronic heart failure. Eur Heart J 1997;18:858-65.
Longo F, Kasper M. Heart failure and Cor Pulmonale. Harrison’s Principles of Internal Medicine, 18th edn. NewYork: McGraw Hill 2011:1902.
Hare JM, Johnson RJ. Uric acid predicts clinical outcomes in heart failure: Insights regarding the role of xanthine oxidase and uric acid in disease pathophysiology. Circulation 2003;107:1951-3.
Terada LS, Guidot DM, Leff JA, et al. Hypoxia injures endothelial cells by increasing endogenous xanthine oxidase activity. Proc Natl Acad Sci USA 1992;89:3362-6.
Feig DI, Kang DH, Johnson RJ, et al. Uric acid and cardiovascular risk. N Engl J Med 2008;359:1811-21.
Cannon PJ, Stason WB, Demartini FE, Sommers SC, Laragh JH. Hyperuricemia in primary and renal hypertension. N Engl J Med 1966;275:457-64.
Anand NN, Padma V, Prasad A, et al. Serum uric acid in new and recent onset primary hypertension. J Pharm Bioall Sci 2015;7:54-8.
Bickel C, Rupprecht HJ, Blankenberg S, et al. Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease. Am J Cardiol 2002;89:12-7.
Omidvar B, Ayatollahi F, Alasti M. The prognostic role of serum [2] uric acid level in patients with acute ST elevation myocardial infarction. Journal of the Saudi Heart Association. 2012; 24(2):73-78.
Nadkar MY, Jain VI. Serum uric acid in acute myocardial [5]infarction. JAPI. 2008; 56(10):759-62
Tunstall-Pedoe H, Kuulasmaa K, Mähönen M, Tolonen H, [8]Ruokokoski E, Amouyel P. Contribution of trends in survival and coronary event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA Project populations. The Lancet. 1999; 353(9164):1547-57.
Xavier D, Pais P, Devereaux PJ, Xie C, Prabhakaran D, Reddy [9]KS, et al. Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data. The Lancet. 2008; 371(9622):1435-42.
Shetty S, Rao AH, AK SK. Serum uric acid as a prognostic [10]biomarker & its correlation with killip class in acute myocardial infarction. International Journal of Biomedical Research. 2013;4(7):312-16.
Timóteo AT, Lousinha A, Labandeiro J, Miranda F, Papoila AL, [11]Oliveira JA, et al. Serum uric acid: a forgotten prognostic marker in acute coronary syndromes?. Euro Heart J Acute Cardiovas Care. 2013 ;2(1):44-52.
El-Menyar A, Zubaid M, AlMahmeed W, Sulaiman K, AlNabti A, [12]Singh R, et al. Killip classification in patients with acute coronary syndrome: insight from a multicenter registry. Am J Emerg Med. 2012; 30(1):97-103.
Nozari Y, Geraiely B. Correlation between the serum levels of [13]uric acid and HS-CRP with the occurrence of early systolic failure of left ventricle following acute myocardial infarction. Acta Med Iran. 2011; 49(8):531–35.
Kojima S, Sakamoto T, Ishihara M, Kimura K, Miyazaki S, [14]Yamagishi M, et al. Prognostic usefulness of serum uric acid after acute myocardial infarction (the Japanese Acute Coronary Syndrome Study). Am J Cardiol. 2005; 96(4):489-95.
Pasalic D, Marinkovic N, Feher-Turkovic L. Uric acid as one [15]of the important factors in multifactorial disorders – facts and controversies. Biochemia Medica. 2012;22(1):63–75
Homayounfar S, Ansari M, Kashani KM. Evaluation of [16]independent prognostic importance of hyperuricemia in hospital death after acute myocardial infarction. Saudi Med J. 2007;28(5):759–61.
Published
Issue
Section
License
Copyright (c) 2024 International Archives of BioMedical and Clinical Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
