Bacteriological profile and antibiotic susceptibility pattern of Intensive care unit patients in a tertiary care institute: An observational study
DOI:
https://doi.org/10.21276/vfarkg08Keywords:
Intensive care units, Bacteriological profile, Antibiotic Sensitivity patternAbstract
Background: Intensive care units (ICU) are considered as high-risk areas in a healthcare setting. Patients admitted in ICU are at a higher risk of developing nosocomial infections and thus at equally greater risk of developing infections caused by drug resistant pathogens. Frequent invasive interventions and empirical antibiotic therapy adds to the risk. The present study was, therefore, designed to describe the sensitivity pattern of microbial isolates from patients in ICUs of a tertiary care rural based teaching institute.
Material & Methods: An observational prospective study was conducted over a period of one year in a tertiary care teaching institute. Different types of clinical samples were collected from patients admitted in ICUs. All the samples were processed according to standard microbiological guidelines for isolation of microorganisms and their sensitivity pattern.
Results: A total of 1165 clinical samples were received in the Microbiology laboratory out of which 468 (40%) samples showed significant microbial growth. The maximum rate of isolation of pathogen was from pus sample (26%) followed by blood (24%) and respiratory specimens (24%). The most predominant isolates were gram negative organisms (75.6%), Escherichia coli (36 %) followed by Klebsiella (27%) and Acinetobacter (15%). Among gram-positive isolates CoNS (45%) was most predominant. Of all the gram-negative isolates 75(21%) were multidrug resistant organisms. Among the multidrug resistant organisms ESBL (77.3%) production was most common.
Conclusions: Regular and appropriate microbiological surveillance for identifying the prevalent pathogens and their antibiotic sensitivity pattern is important to guide in effective management of patients.
Downloads
References
Ahmed J, Jan A, Nawaz G, Khan M. Epidemiology and antibiotic susceptibility
of bacterial isolates from Northern Pakistan. African Journal of Microbiology
Research, 2011;5(28), pp.4949-4955.
Enas A Daef and Nahla M. Elsherbininy. Clinical and Microbiological Profile of
Nosocomial Infections in Adult Intensive Care Units at Assiut University
Hospitals, Egypt.J.Am.Sci2012;8(12):1239-1250].(ISSN:1545-1003).
https://academicjournals.org/journal/AJMR/article-abstract/F6DC3B059645
Manoj Kumar, Ashok Kumar Sharma, B. L. Sherwal, Neha. Antimicrobial
Resistance Pattern of Bacterial Isolates from ICU Patients in Tertiary Care
Hospital. Int J Med Res Prof. 2017; 3(2):364-68.
DOI:10.21276/ijmrp.2017.3.2.076.
Balaji S, Karthik S, Pasupuleti M, Kannan G, Srinivasan D, Sekar U, et al. A
Study on Evaluation of Appropriateness of Antibiotics Used in the Intensive Care
Unit Settings of a Tertiary Care Teaching Hospital. Int J Pharm Sci Rev Res.
;28(2):28-34.
Gohel K, Jojera A, Soni S et al. Bacteriological profile and drug resistance
patterns of blood culture isolates in a tertiary care nephrology teaching institute.
Biomed Res Int. vol. 2014, article ID 153747,5 pages, 2014.doi:
1155/2014/153747.
Clinical and Laboratory Standards Institute. Performance Standards for
Antimicrobial Susceptibility Testing; CLSI Document M100-Ed31, 2021.
Bhatia A, Kalra J, Kohli S, Kakati B, Kaushik R. Antibiotic resistance pattern in
intensive care unit of a tertiary care teaching hospital. Int J Basic Clin Pharmacol
;7:906-11. https://dx.doi.org/10.18203/2319-2003.ijbcp20181633
Wattal C, Raveendran R, Goel N, Oberoi JK, Rao BK. Ecology of blood stream
infection and antibiotic resistance in intensive care unit at a tertiary care hospital
in North India. Braz J Infect Dis. 2014;18(3):245-51. doi:
1016/j.bjid.2013.07.010. Epub 2014 Jan 3.
Molay Banerjee, Abhishek Arun, Sandeep Kr. Gupta, Ashok Kr. Mishra,
Abhilasha Gupta et al. Pattern of pathogens and their sensitivity isolated from
nosocomial infections in a tertiary care hospital. International Journal of Current
Microbiology and Applied Sciences. Volume 3 Number 12(2014); 398-403.
Anurag Ambroz Singh, Manpreet Kaur, Abhishek Singh, Shewtank Goel,
Avinash Surana, Anu Bhardwaj, Sanjeet Panesar, Virender K Chhoker, Richa
Chaturvedi et al. Prevalence of microbial infection and strategic pattern of
antimicrobial resistance among intensive care unit patients in a tertiary care
teaching hospital from rural Northern India. International Archives of Integrated
Medicine 2015 Mar, Vol. 2, Issue 3, Page 14- 20.
Savanur SS, Gururaj H. Study of Antibiotic Sensitivity and Resistance Pattern of
Bacterial Isolates in Intensive Care Unit Setup of a Tertiary Care Hospital. Indian
J Crit Care Med. 2019;23(12):547-555. doi:10.5005/jp-journals-10071-23295
Zaveri JR, Patel SM, Nayak SN, Desai K, Patel P. A study on bacteriological
profile and drug sensitivity and resistance pattern of isolates of the patients
admitted in ICUs of a tertiary care hospital in Ahmadabad. NJMR2012;2:330-4.
Sheth KV, Patel TK, Malek SS, Tripathi CB. Antibiotic sensitivity pattern of
bacterial isolates from the intensive care unit of a tertiary care hospital in India.
Trop J Pharm Res. 2012;11(6):991-9.
Rajan r, Rao AVR: Antibiogram of gram negative bacterial isolates from
intensive care unit at a tertiary care hospital. IJAR.2016,6:344-47.
Pattanayak C, Patanaik SK, Datta PP, Panda P. A study on antibiotic sensitivity
pattern of bacterial isolates in the intensive care unit of a tertiary care hospital in
Eastern India. Int J Basic Clin Pharmacol 2013; 2:153-9.
Pawar SK, Patil SR, Karande GS, Mohite ST, Pawar VS. Antimicrobial
Sensitivity Pattern of Clinical Isolates in Intensive Care Unit in a Tertiary Care
Hospital from Western India. Int J Sci Stud 2016;4(2):108-113.
Shalini S, Kranthi K, Gopalkrishna BK. The microbiological profile of
nosocomial infections in the intensive care unit. J Clin Diagn Res 2010;4:3109-
Pampita Chakraborty and Sukumar Mukherjee. 2016. A Study on the Prevalence
and Microbiological Profile of Nosocomial Infections in the ICU of a Tertiary
Care Hospital in Eastern India. Int.J.Curr.Microbiol.App.Sci. 5(5):920-925. doi:
Downloads
Published
Issue
Section
License
Copyright (c) 2024 International Archives of BioMedical and Clinical Research (IABCR)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors are required to sign and submit the completed “Copyright transfer Form” upon acceptance of publication of the paper. This is determined by a publishing agreement between the author and International Archives of Biomedical and Clinical Research. These rights might include the right to publish, communicate and distribute online. Author(s) retain the copyright of their work. International Archives of Biomedical and Clinical Research supports the need for authors to share, disseminate and maximize the impact of their research.
