Diurnal variability of FEV1 and Salivary cortisol with Anthropometric and cardiovascular parameters in healthy individuals
Background: Airways exhibit a definite circadian variation in caliber and this phenomenon is amplified in excess of respiratory distress such as asthma or COPD. FEV1 is considered a reliable airway measurement. Body Mass index is linked with several diseases and affects various systems. Salivary cortisol, a direct measure of stress can impact respiratory and cardiovascular function. This study was taken up to find any association of FEV1 and salivary cortisol with BMI and pulse pressure.
Methods: Spirometric analysis was performed to check for diurnal variability of FEV1 among 18 – 35-year-old. BMI, PP and salivary cortisol were measured. SPSS 21.0 was used for analysis of data.
Results: Diurnal variations were found to be significant in both FEV1 and Salivary cortisol. FEV1 values increased from 2.71 + 0.93 in the morning to 2.86 + 0.57 in the evening while salivary cortisol decreased from 1.52 + 0.30 to 1.17 + 0.39. Pulse pressure showed no diurnal pattern. When compared between genders, all variable except BMI was found to be significant.
Conclusion: The correlation found will help us to categorise high risk population and prioritize early diagnosis and patient management.
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