Knowledge and Attitude of Adult Saudi Community towards Premarital Screening Program (Sickle Cell Anemia/Thalassemia) in Riyadh Province of Saudi Arabia

Premarital Screening Program of SCA & Thalassemia

  • Shujaat Khan Shaqra University
  • Mohammad Azhar Rashikh Shaqra niversity
  • Saad Mohammed Alsaab Shaqra University
  • Nemer Alotaibi Shaqra University
  • Fahad Mohammed Aldehaim Shaqra University
  • Dinesh Dimri Shaqra University
  • Prasanna Mohana Bhaskaran Shaqra University
Keywords: Hereditary hemoglobinopathies, sickle cell anemia, thalassemia, Middle East


Background: Premarital Screening (PMS) program in Saudi Arabia aims at limiting the spread of hereditary diseases like Sickle Cell Anemia (SCA) and Thalassemia and infectious diseases like Hepatitis B&C and Human immunodeficiency virus (HIV). Although the PMS program is reducing the percentage of incompatible marriages, the prevalence of hemoglobinopathies is still remaining high. With the changing perception of the general population towards the PMS program, an examination of community awareness and attitude toward PMS is needed to find ways for reducing the prevalence of diseases.

Objective: The aimed to assess the present knowledge and attitude of the adult Saudi community from Riyadh Province to the premarital screening (PMS) program for hemoglobinopathies.

Methodology: This cross-sectional study was conducted on 676 participants from the general population in June-September 2022. The electronic questionnaire was used to assess the sociodemographic data, knowledge, and attitude toward the PMS program. 

Results: Out of the 676 participants, 58% were females, and 42% were males. 54% had consanguineous marriages and 5.6% hemoglobinopathies in the family. 92.6% had heard of PMS, and participants knew that SCA and thalassemia can be detected by PMS 47.4% and 36.3% respectively. 96.3% agreed on suggesting PMS to others, 83.2% considered PMS incompatible marriage is wrong, and 78.6% considered associated genetic counselling is important. 22.7% preferred consanguineous marriage over non-consanguineous. For raising awareness, 97.6%, 85.9%, 84.6%, and 81.2% of respondents felt the need for community participation through the internet, social media, and medical education in schools respectively.

Conclusions: Most participants have a positive attitude but only superficial knowledge of the PMS program and one-third are still unaware of its use for the prevention of hemoglobinopathies, especially thalassemia. Increasing the knowledge about the importance of the PMS program and associated genetic counselling should be done with multiple information sources in a well-organized way that suits the community’s requirements. 


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Author Biographies

Shujaat Khan, Shaqra University

MD., Clinical Pathologist, Department of Pathology and Associated labs, College of Medicine, Dawadmi campus, Shaqra University, Kingdom of Saudi Arabia

Saad Mohammed Alsaab, Shaqra University

MD., Department of Internal medicine, College of Medicine at Dawadmi, Shaqra University, KSA

Nemer Alotaibi , Shaqra University

MD., Department of Pediatrics, College of Medicine, Dawadmi, Shaqra University, KSA

Fahad Mohammed Aldehaim, Shaqra University

MBBS, College of Medicine at Dawadmi, Shaqra University, KSA

Dinesh Dimri, Shaqra University

MD., Department of Preventive & Social Medicine, College of Medicine, Shaqra University, KSA

Prasanna Mohana Bhaskaran, Shaqra University

MD., Department of Microbiology, College of Medicine, Shaqra University, KSA


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How to Cite
Khan S, Rashikh MA, Alsaab SM, Alotaibi N, Aldehaim FM, Dimri D, Bhaskaran PM. Knowledge and Attitude of Adult Saudi Community towards Premarital Screening Program (Sickle Cell Anemia/Thalassemia) in Riyadh Province of Saudi Arabia. Int Arch BioMed Clin Res [Internet]. 2023Jan.30 [cited 2023Sep.26];8(4):PA1-PA5. Available from: