Histological Variants of Leiomyoma: A Great Impersonator posing a Diagnostic Challenge - Three year Study in Delhi NCR

  • Mukta Pujani Professor & Head, Dept. of Pathology, ESIC Medical College, Faridabad, Haryana
  • Charu Agarwal Associate Professor, Dept. of Pathology, ESIC Medical College, Faridabad, Haryana
  • Varsha Chauhan Assistant Professor, Dept. of Pathology, ESIC Medical College, Faridabad, Haryana
  • Dipti Sidam Assistant Professor, Dept. of Pathology, ESIC Medical College, Faridabad, Haryana
Keywords: Leiomyoma, Secondary change, Hysterectomy, histologic variant


Background: Objectives: Uterine smooth muscle tumours are diagnostically challenging as well as scientifically intriguing with leiomyoma being the most common. On review of literature there are numerous studies on audit of hysterectomy specimens worldwide, however, studies focusing on detailed histopathological analysis of leiomyomas are limited. Thereby, this study was conducted to identify the secondary changes as well as histological variants of leiomyoma, their frequency of occurrence and other associated clinicopathological factors

Methods: A retrospective audit of all the hysterectomy and myomectomy specimens was conducted over a period of 3 years (Jan 2016 to Dec 2018) comprising of a total of 155 cases with 388 leiomyomas (LM). The clinical details were retrieved, and histopathological slides reviewed for cellularity, mitosis, atypia, necrosis, any secondary changes or specific variants.

Results: On histopathology, 19.1% LM showed degenerative changes and histologic variants were observed in 6.18% LM. Hyaline change was the most frequent degenerative phenomenon in 82.43% (60/74) while cellular leiomyoma was the most common variant in 37.5% (9/24) LM.

Conclusion: Certain histological variants make the differentiation from malignant tumors challenging. A thorough tissue sampling and strict adherence to histologic criteria coupled with ancillary techniques like immunohistochemistry can help in excluding malignancy in most of the cases. Awareness regarding these is very important amongst young pathologists to avoid misdiagnosis and overtreatment leading to unwarranted stress to the patient.


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How to Cite
Pujani M, Agarwal C, Chauhan V, Sidam D. Histological Variants of Leiomyoma: A Great Impersonator posing a Diagnostic Challenge - Three year Study in Delhi NCR . Int Arch BioMed Clin Res [Internet]. 2022Dec.6 [cited 2023Sep.26];8(3):PA1-PA4. Available from: https://iabcr.org/index.php/iabcr/article/view/812