Prevalence of Cardiovascular Disease Risk Factors in Postmenopausal Women: A Cross-sectional Prospective Study

  • P Leelakumari Associate Prof., Department of General Medicine, S.R. Medical College and Research Centre Akhathumuri P. O Vennicode, VARKALA, Thiruvanathapuram, Kerala 695318
Keywords: Menopause, postmenopausal, hypertension, cardiovascular Disease


Background: Cardiovascular disease caused by atherosclerosis is rare in premenopausal women; the incidence steeply increases after menopause. Unresolved issue remains if these changes are caused rather by chronological aging or by menopause accompanied by decrease in the estrogen concentration. Methods: This study was conducted during the period of 2 year in one of the rural health centre in Sothern  India. This is observational, cross-sectional prospective study. a total of 400 consecutive postmenopausal women (cessation of menstruation for 1 year) were recruited. Results: Mean age at menopause was 48.25 years, mean number of menopausal symptoms was 8.97 ± 3.68, and mean duration since menopause was (MDSM = 3.10 years). Fatigue, lack of energy (80%), cold hand and feet, rheumatology-related symptoms (70%) cold sweats, weight gain, irritability and nervousness (60%), palpitation of heart, excitable/anxiety (40%) each were common complaints. Hypertension was diagnosed or a person was a known hypertensive (72%). Diabetes was diagnosed, or a person was known diabetic in 37%. BMI  25 kg/m2 in 65%. Truncal obesity with WHR > 0.8 in 59% females, whereas abdominal obesity with waist size >88 cm was in 54% women.

Conclusions: In postmenopausal women from rural areas high prevalence of most of the conventional CVRFs, especially diabetes, hypertension, dyslipidaemia, obesity, and other risk factors.


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1. World Health Organization (WHO). Research on the menopause in the 1990: report of a WHO Scientific Group. WHO tech rep ser.; 1990. p. 12-20.
2. Meirelles RM. Menopausa e síndrome metabólica. Arq Bras Endocrinol Metabol. 2014;58:2.
3. Paolillo FR, Milan JC, Paolillo AR, Lopes SLB, Kurachi C, Bagnato VS, et al. Impact of fat distribution on metabolic, cardiovascular and symptomatic aspects in postmenopausal women. Int J Diabetes Dev Ctries. 2014;34:32-9.
4. K.A. Matthews, C.J. Gibson, S.R. El Khoudary, R.C. Thurston, Changes in cardiovascular risk factors by hysterectomy status with and without oophorectomy: Study of Women's Health Across the Nation, Journal of the American College of Cardiology 62 (2013) 191-200.
5. K.A. Matthews, E. Meilahn, L.H. Kuller, et al., Menopause and risk factors for coronary heart disease, New England Journal of Medicine 321 (1989) 641-646.
6. P. Collins, G. Rosano, C. Casey, et al., Management of cardiovascular risk in the peri-menopausal woman: a consensus statement of European cardiologists and gynaecologists, European Heart Journal 28 (2007) 2028-2040.
7. R.A. Wild, Atherosclerotic burden during the menopausal transition is a wakeup call,Menopause 19 (2012) 1-2.
8. L. Mosca, E.J. Benjamin, K. Berra, et al., Effectiveness-based guidelines for the prevention of cardiovascular disease in women - 2011 update: a guideline from the American Heart Association, Journal of American College of Cardiology 57 (2011) 1404-1423.
9. L. Mosca, E. Barrett-Connor, N.K. Wenger, Sex/gender differences in cardiovascular disease prevention: what a difference a decade makes, Circulation 124 (2011) 2145- 2154
10. Mukherjee AK. India's health - Today and tomorrow. J Indian Med Assoc 1995;93:312-5.
11. Reddy KS, Yusuf S. Emerging epidemic of cardiovascular disease in developing countries. Circulation 1998;97:596-601.
12. Bulatao RA, Stephens PW. Demographic estimates and projections, by region, 1970-2015. In: Jamison DT, Mosley WH, editors. Disease Control Priorities in Developing Countries. (Health Sector Priorities Review No. 13). Washington: World Bank; 1990.
13. World Health Organization. The World Health Report 2002. Geneva, Switzerland: WHO; 2002.
14. Burden of Disease in India. New Delhi: Ministry of Health and Family Welfare, Government of India. Background Papers for the National Commission on Macroeconomics; 2005.
15. Goenka S, Prabhakaran D, Ajay VS, Reddy KS. Preventing cardiovascular disease in India - Translating evidence to action. Curr Sci 2009;97:367-77.
16. Reddy KS, Prabhakaran D, Chaturvedi V, Jeemon P, Thankappan KR, Ramakrishnan L, et al. Methods for establishing a surveillance system for cardiovascular diseases in Indian industrial populations. Bull World Health Organ 2006;84:461-9.
17. Norman G, George C, Krishnamurthy A, Mukherjee D. Burden of cardiovascular risk factors of a rural population in South India using the WHO multivariable risk prediction algorithm. Int J Med Sci Public Health 2014;3:764-8.
18. Collins P, Rosano G, Casey C, Daly C, Gambacciani M, Hadji P, et al. Management of cardiovascular risk in the perimenopausal women: A consensus statement of European cardiologists and gynecologists. Climacteric 2007;10:508-26.
19. Kasliwal RR, Kulshreshtha A, Agrawal S, Bansal M, Trehan N. Prevalence of cardiovascular risk factors in Indian patients undergoing coronary artery bypass surgery. J Assoc Physicians India 2006;54:371-5.
20. Gupta R, Sarna M, Thanvi J, Rastogi P, Kaul V, Gupta VP. High prevalence of multiple coronary risk factors in Punjabi Bhatia community: Jaipur Heart Watch-3. Indian Heart J 2004;56:646-52.
21. Gupta R, Gupta VP, Sarna M, Bhatnagar S, Thanvi J, Sharma V, et al. Prevalence of coronary heart disease and risk factors in an urban Indian population: Jaipur Heart Watch-2. Indian Heart J 2002;54:59-66.
22. De Lorenzi DRS, Danelon C, Saciloto B, Padilha Jr I. Fatores indicadores da sintomatologia climatérica? Rev Bras Ginecol Obstet. 2005;27:12-9.
23. Chedraui P, Aguirre W, Hidalgo L, Fayad L. Assessing menopausal symptoms among healthy middle aged women with the Menopause Rating Scale. Maturitas. 2007;57:271-8.
24. Fernandez-Alonso AM, Cuadros JL, Chedraui P, Mendoza M, Cuadros ÁM, Pérez-López FR. Obesity is related to increased menopausal symptoms among Spanish women. Menopause Int. 2010;16:105-10
25. Da Fonseca AM, Bagnoli VR, Souza MA, Azevedo RS, De Barros Couto Júnior E, Júnior JMS, et al. Impact of age and body mass on the intensity of menopausal symptoms in 5968 Brazilian women? Gynecol Endocrinol. 2013;29:116-8
How to Cite
Leelakumari, P. (2017). Prevalence of Cardiovascular Disease Risk Factors in Postmenopausal Women: A Cross-sectional Prospective Study. International Archives of BioMedical and Clinical Research, 3(4), 13-16.