Incidence and Prevalence of Osteogenic and Non Osteogenic Bone Tumors in Western Uttar Pradesh

  • Sadaf Mirza Associate Professor, Department of Pathology, Mayo Institute of Medical Sciences, Gadia, Barabanki UP
  • Priyanka Singh Associate Professor, Department of Pathology, Mayo Institute of Medical Sciences, Gadia, Barabanki UP
  • Mohammad Kashif Associate Professor, Department of Pediatrics, Mayo Institute of Medical Sciences, Gadia, Barabanki UP
  • Arshad Ikram Professor, Department of Pathology, Mayo Institute of Medical Sciences, Gadia, Barabanki UP
Keywords: Bone tumors, Immunohistochemistry, Osteonectin, Osteosarcoma

Abstract

Introduction: Primary bone tumors are uncommon lesions constituting less than 1% of all cancers. In these primary bone tumours benign bone tumours are common than malignant tumours. This study was conducted to determine the spectrum and demographic characteristics of bone tumors and tumor like lesions at a tertiary care centre in western Uttar Pradesh.

Material and method- This is a five year, retrospective as well as a prospective study done on a total of 200 cases of benign and malignant bone lesions. After a detailed clinical history and local examination, paraffin sections of resected specimen were studied by Hematoxylin and eosin, immune-histochemical stain and osteonectin.

Result- Benign and malignant tumour accounted for 70% and 30% of the total cases. Most common tumour in this study was giant cell tumour (22.5%) cases followed by osteosarcoma (18%), fibrous dysplasia (9%), aneurysmal bone cyst (7.5%), Osteochondroma (7%), callus formation (7%), osteoid osteoma (5%), chondrosarcoma (4.5%) and Enchondroma (4%).  Incidence of bone tumour was more in female population. 

Conclusion- Giant cell tumours are most common benign bone tumour and osteosarcoma is most common malignant bone tumour.

Downloads

Download data is not yet available.

References

1. Mohammed A, Sani MA, Hezekiah IA, Enoch AA. Primary bone tumours and tumour-like lesions in children in Zaria, Nigeria: Afr J PaediatrSurg 2010;7:16-18.
2. Dorfman HD and Czerniak B.Bone cancers: Cancer 1995; 75:203-210.
3. UnniKK,Inwards CY, Bridge JA, Kindblom LG, Wold LE. Tumors of the bones and joints. In AFIP atlas of tumor pathology, series 4. American Registry of Pathology, Washington DC, 2005, Fascicle 2, vol. 4.
4. Rosai J. Ackerman's Surgical Pathology. In: Rosai J, editor. St. Louis: Mosby 2011;pp2024-2025.
5. Aston W, Briggs T, Solomon L. Tumors. In: Solomon L, Warwick D, Nayagam S, editors. Apley's System of Orthopaedics and Fractures. 9th ed. London: Hodder Arnold Hoddereducation 2010;187-224.
6. Klein MJ and Siegal GP. Osteosarcoma anatomic and histologic variants. Am J ClinPathol 2006; 125:555-556.
7. Deshpande A and Hinds PW.The Retinoblastoma Protein in osteoblast differentiation and ostesarcoma.CurrMol Med 2006; 6:809-817.
8. Gulia A, Puri A, Panda PK .Epidemiological data and case load spectrum of patients presenting to bone and soft tissue disease management group at a tertiary cancer center. Ind J of Cancer 2016;53(2 ): 333-338.
9. JainSunila K, , Ravishankar R, Mruthyunjaya, Rupakumar CS, Gadiyar HB, Manjunath GV. Bone tumors in a tertiary care hospital of south India: A review 117 cases. Indian J Med PaediatrOncol2011; 32(2): 82-85.
10. Bahebeck J, Atangana R, Eyenga V, Pisoh A, Sando Z, Hoffmeyer P. Bone tumours in Cameroon: Incidence, demography and histopathology. IntOrthop2003;27:315-317.
11. Turcotte RE, Wunder JS and Isler MH. Giant cell tumor of long bone. A Candian Sarcoma group study .Clin Ortho 2002; 248-258.
12. Campanacci M, Baldani N, Boriani S, Sudanese A. Giant cell tumor of bone. J Bone Joint Surg1987; 69: 104-114.
13. Mc-Grath PJ. Giant cell tumors of bone- An analysis of fifty-two cases. J Bone Joint Surg1972; 54(2): 216-229.
14. Larsson SE, Lorentzon R and Boquist L. Giant cell tumour of bone. A demographic, clinical and histopathological study of all cases recorded in the Swedish cancer registry for the years 1958-1968. J Bone Joint Surg Am 1975; 57: 167-73.
15. Ottaviani G and Jaffe N. The epidemiology of osteosarcoma. Cancer Treat Res. 2009;152:3-13.
16. Simon MA, Aschliman MA, Thomas N, Mankin HJ. Limb salvage treatment versus amputation for osteosarcoma of the distal end of the femur. J Bone Joint Surg Am 1986; 68: 1331-1337.
17. Howlader N, Noone AM, Krapcho M, Neyman N, Aminou R, Altekruse SF, , Kosary CL, Ruhl J, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Chen HS, Feuer EJ, Cronin KA. SEER Cancer Statistics Review, 1975-2009 (Vintage 2009 Populations). Bethesda, MD: National Cancer Institute 2012.
18. Solooki S, Vosoughi AR, Masoomi V. Epidemiology of musculoskeletal tumors in Shiraz, South of Iran. Indian J Med PaediatrOncol 2011;32:187-191.
19. Baena-OcampoLdel C, Ramirez-Perez E, Linares-Gonzalez LM, Delgado-Chavez R. Epidemiology of bone tumors in Mexico City: Retrospective clinicopathologic study of 566 patients at a referral institution. Ann DiagnPathol 2009;13:16-21.
20. Schulz A,JundtG,BerghauserKH,Gehron-RobeyP,Termine JD .Immunohistochemical Study of Osteonectin in Various Types of Osteosarcoma. Am J of Pathol 1988; 132(2):233-238.
21. Jundt G, Schulz A, Berghäuser KH, Fisher LW, Gehron-Robey P, Termine JD. Immunocytochemical identification of osteogenic bone tumors by osteonectin antibodies. Virchows Arch A PatholAnatHistopathol 1989;414(4):345-353.
22. Sakamoto A, Oda Y,Iwamoto Y, Tsuneyoshi M .A comparative study of fibrous dysplasia and osteofibrous dysplasia with regard to expressions of c-fos and c-junproducts and bone matrix proteins: a clinicopathologic review and immunohistochemical study of c-fos, c-jun, type I collagen, osteonectin, osteopontin, and osteocalcin. Hum pathol1999;30(12):1418-1426.
Published
2021-10-09
How to Cite
1.
Mirza S, Singh P, Kashif M, Ikram A. Incidence and Prevalence of Osteogenic and Non Osteogenic Bone Tumors in Western Uttar Pradesh . Int Arch BioMed Clin Res [Internet]. 2021Oct.9 [cited 2021Oct.23];7(3):PA5-PA9. Available from: https://iabcr.org/index.php/iabcr/article/view/757