Evaluate an Association Between Diet and Acne Vulgaris: A Cross Sectional Study
Background: Acne vulgaris is a common chronic skin disease involving blockage and/or inflammation of pilosebaceous units. The possible causes of acne can be hormonal overstimulation of the pilosebaceous units of genetically susceptible individuals. Endogenous reproductive and growth hormones, exogenous reproductive hormones, insulin and endogenous insulin-like growth hormone-1, sourced from and stimulated by dairy and high glycemic load foods, all appear to contribute to this overstimulation.
This study was designed to identify the possible associations of diet with acne vulgaris.
Methods: A cross sectional study was conducted among 50 acne vulgaris patients and 50 controls aged 18 to 30 years from March 2020 to March 2021. To determine acne severity comprehensive acne severity scale (CASS) was used. A questionnaire comprising questions about patient’s family history and dietary patterns was distributed. Subjects were asked to record their food intake on two weekdays and one day on a weekend in a three day food diary. Anthropometric measurements including body weight, height and body fat percentage were taken. Acne severity was graded as mild moderate and severe.
Results: It was seen acne patients had significantly higher dietary glycemic load (180 ±40) compared to control group (120 ± 25) (p < 0.001). The frequency of milk, and ice-cream consumptions was significantly higher in cases compared to controls. Females in the case group had a higher daily energy intake compared to their counterparts in the control group. No significant difference was found in other nutrient intakes, body Mass Index, and body fat percentage.
Conclusion: Glycemic load diet and frequencies of milk and ice cream intake were positively associated with acne vulgaris.
Available from: http://www.emedicine.medscape.com/article/1069804-print. [Last accessed on 2008 Dec 15].[Google Scholar]
2. Robinson HM: The acne problem. South Med J 1949, 42:1050–1060.
3. Fulton JE, Plewig G, Kligman AM: Effect of chocolate on acne vulgaris. JAMA 1969, 210(11):2071–2074.
4. Burris J, Rietkerk W, Woolf K. Relationships of self-reported dietary factors and perceived acne severity in a cohort of New York young adults. J AcadNutr Diet 2014;114:384-92. [Google Scholar]
5. Cordain L. Implications for the role of diet in acne. SeminCutan Med Surg 2005;24:84-91.[Google Scholar]
6. Kaymak Y, Adisen E, Ilter N, Bideci A, Gurler D, Celik B: Dietary glycemic index and glucose, insulin, insulin-like growth factor-I, insulin-like growth factor binding protein 3, and leptin levels in patients with acne. J Am AcadDermatol 2007, 57(5):819–823
7. Adebamowo CA, Spiegelman D, Berkey CS, Danby W, Rockett HH, Colditz GA, Willet WC, Homes MD: Milk consumption and acne in adolescent girls. DermatolOnline J 2006, 12(4):1
8. Smith RN, Mann NJ, Braue A, Makelainen H, Varigos GA: A low-glycemicloaddietimproves symptoms in acne vulgaris patients: a randomized controlled trial. Am J ClinNutr 2007, 86(1):107–115.
9. Adebamowo CA, Spiegelman D, Danby FW, Frazier AL, Willett WC, Holmes MD: High school dietary dairy intake and teenage acne. J Am AcadDermatol 2005, 52(2):207–214
10. Smith R, Varigos G, Braue A, Mann NJ: The effect of a low glycemic load diet on acne vulgaris and the fatty acid composition of skin surface triglycerides. J DermatolSci 2008, 50(1):41–52
11. Adebamowo CA, Spiegelman D, Berkey CS, Danby W, Rockett HH, Colditz GA, et al: Milk consumption and acne in teenaged boys. J Am Acad Dermatol 2008, 58(5):787–793.
12. Tan JK, Tang J, Fung K, Gupta AK, Thomas DR, Sapra S, et al. Development and validation of a comprehensive acne severity scale. J Cutan Med Surg 2007, 11(6):211– 216
13. WHO: Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004, 363:157–163.
14. Foster-Powell K, Holt SHA, Brand-Miller JC: International Table of Glycemic Index and Glycemic Load Values. Am J ClinNutr 2002, 76:5–56.
15. Cordain L, Eades MR, Eades MD. Hyperinsulinemic diseases of civilization: More than just syndrome X. Comp BiochemPhysiol A MolIntegrPhysiol 2003;136:95-112.[Google Scholar]
16. T. Longvah. Indian food composition table. National institute of nutrition;2017.
17. Atkinson FS, Foster-Powell K, Brand-Miller JC: International Table of Glycemic Index and Glycemic Load Values: 2008. Diabetes Care 2008, 31:2281–2283
18. Smith R, Mann N, Braue A, Makelainen H, Varigos G: The effect of a high-protein, low glycemic–load diet versus a conventional, high glycemic–load diet on biochemical parameters associated with acne vulgaris: A randomized, investigator-masked, controlled trial. J Am AcadDermatol 2007, 57(2):247–256
19. Adebamowo CA, Spiegelman D, Berkey CS, Danby W, Rockett HH, Colditz GA, et al. Milk consumption and acne in adolescent girls. Dermatol Online J 2006, 12(4):1
20. NikShanita S, NikMazlan M: Chapter 4 Carbohydrates. In Recommended Nutrient Intakes for Malaysia.National Coordinating Committee on Food and Nutrition (NCCFN).A report of the Technical Working Group on Nutritional Guidelines. Edited by Mohd Ismail N, Khor GL, Tee ES. Putrajaya: Ministry of Health Malaysia; 2005:42–51.
21. Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J: Acne vulgaris: a disease of Western civilization. Arch Dermatol 2002, 138(12):1584–1590.
22. Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J, et al. Acne vulgaris: A disease of Western civilization. Arch Dermatol 2002;138:1584-90.[Google Scholar]
23. Kim J, Ko Y, Park YK, Kim NI, Ha WK, Cho Y, et al. Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris. Nutrition 2010;26:902-9.[Google Scholar]
24. Di Landro A, Cazzaniga S, Parazzini F, Ingordo V, Cusano F, Atzori L, et al. Family history, body mass index, selected dietary factors, menstrual history, and risk of moderate to severe acne in adolescents and young adults. J Am AcadDermatol 2012;67:1129-35.[Google Scholar]
25. Smith RN, Mann NJ, Braue A, Makelainen H, Varigos GA: A low-glycemicload diet improves symptoms in acne vulgaris patients: a randomized controlled trial. Am J ClinNutr 2007, 86(1):107–115.
26. Nagpal M, De D, Handa S, Pal A, Sachdeva N. Insulin resistance and metabolic syndrome in young men with acne. JAMA Dermatol 2016;152:399-404.[Google Scholar]
27. Cordain L. Implications for the role of diet in acne. SeminCutan Med Surg 2005;24:84-91.Google Scholar]
28. Berra B, Rizzo AM. Glycemic index, glycemic load: New evidence for a link with acne. J Am CollNutr 2009;28Suppl:450S-454S.[Google Scholar]
29. Jung JY, Yoon MY, Min SU, Hong JS, Choi YS, Suh DH: The influence of dietary patterns on acne vulgaris in Koreans. Eur J Dermatol 2010, 20:768–772.
30. El-Akawi Z, Abdel-Latif NA, Abdul-Razzak K, Al-Aboosi M: Factors believed by Jordanian acne patients to affect their acne condition. East Mediterr Health J 2006, 12(6):840–846.
31. Hoyt G, Hickey MS, Cordain L: Dissociation of the glycaemic and insulinaemic responses to whole and skimmed milk. Br J Nutr 2005, 93:175–177.
32. Norat T, Dossus L, Rinaldi S, Overvad K, Grønbaek H, Tjønneland A, et al: Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women. Eur J ClinNutr 2007, 6:91–98
33. Danby FW: Nutrition and acne. ClinDermatol 2010, 28:598–604
34. Crowe FL, Key TJ, Allen NE, Appleby PN, Roddam A, Overvad K, et al: The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition. CancEpidemiol Biomarkers Prev 2009, 18:1333–1340
35. 35:Kim J, Ko Y, Park YK, Kim NI, Ha WK, Cho Y, et al. Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris. Nutrition 2010;26:902-9.[Google Scholar]
36. Bataille V, Snieder H, MacGregor A, Sasieni P, Spector T: The influence of genetics and environmental factors in the pathogenesis of acne: a twin study of acne in women. J Invest Dermatol 2002, 119(6):1317–1322.
37. Kang S, Kim J, Imm J, Oh S, Kim S: The effects of dairy processes and storage on insulin-like growth factor-I (IGF-I) content in milk and in model IGF-I-fortified dairy products. J Dairy Sci 2006, 89(2):402–409.
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