Correlation of Anthropometric Measurements with the Serum Total Estradiol Level in Adult Males

  • Enam Ahmad Assitant Professor, Department of Physiology, Moti Lal Nehru Medical College, Prayagraj -211001, U.P.,India
  • Abid Ahsan MRA Medical College Ambedkar Nagar- 224227, U.P., India
  • Sonu Kumar Lady Hardinge Medical College, New Delhi-110001, India
Keywords: BMI (body mass index), WHR (waist hip ratio), Obesity, serum estradiol (E2)


Background: In males, normal Estradiol (E2) levels are required for proper fertility, cardiovascular health and bone mass deposition etc. which changes with Age, Body weight, BMI and WHR. The present study was planned to study the serum total estradiol (E2) level according to body mass index and waist hip ratio in adult males

Methods: The present study was a cross sectional study, conducted on 89 adult males (aged 18-50 years). Anthropometric measurements of each subject were measured and BMI & WHR were calculated. Morning Venous blood sample was drawn between 8-11 A.M. from each subject and serum was separated. Serum Total estradiol was measured using ELISA.

Results: In non-obese “Group A” (BMI <25 kg/m2), Serum Total Estradiol was 18.9±7.71 pg/ml and in overweight and obese “Group B” (BMI ≥ 25 kg/m2) it was 52.83±29.23 pg/ml (p<0.05). In subjects with WHR < 0.9 “Group C” serum Total Estradiol was 17.58±7.87 pg//ml and whose WHR ≥ 0.9 “Group D” it was 48.55±28.69 pg/ml (p<0.05).Thus it was concluded that Serum Total Estradiol level significantly increased in “Group B” overweight and obese (BMI ≥ 25 kg/m2) and  in Group “D’ subjects, with Waist Hip Ratio ≥ 0.9 as compared to “Group A” non-obese (BMI <25 kg/m2) and subjects in Group “C” with Waist Hip Ratio < 0.9.

Conclusion: Therefore we can infer that serum total estradiol might increase significantly because of more body fat mass in overweight and obese subjects i.e. subjects who had increased body mass index and waist hip ratio.


Download data is not yet available.


1. Zondek B. Mass excretion of oestrogenic hormone in the urine of the stallion. Nature (London) 1934; 193: 209–210.
2. Carreau S, Genissel C, Bilinska B and Levallet J. The oestrogen sources in the testis and the reproductive tract of the male. Int. J. Androl. 1999; 2: 211-223. (doi: 10.1046 / j.13652605.1999.0017 . x) [ PubMed ]
3. Carreau S, Bourguiba S, Delalande C, Silandre D, Said L, Galeraud-Denis I, Lambard S. Estrogens and male reproduction. Curr. Med. Chem. Immunol. Endocrinol. Metab. Agents 2008; 8: 59–65. (doi:10.2174/187152208783790679).
4. Hess R. E. Estrogen in the adult male reproductive tract: a review. Reprod. Biol. Endocrinol. 2003; 9: 52. (doi:10.1186 / 1477-7827-1-52) [PMC free article] [PubMed]
5. Akingbemi B T. Estrogen regulation of testicular function. Reprod Biol Endocrinol. 2005; 27: 3 –51.
6. Muller M, den Tonkelaar I, ThijssenJH, Grobbee DE and van der Schouw YT. Endogenous sex hormones in men aged 40–80 years. European Journal of Endocrinology 2003; 149: 583–589.
7. Nielsen Torben Leo, Hagen Claus, Wraae Kristian, Brixen Kim, Hyltoft Petersen Per, Haug Eqil, Larsen Rasmus and Andersen Marianne. Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men. Journal of Clinical Endocrinology & Metabolism July 1, 2007; 92 (7): 2696-2705.
8. Chavarro Jorge E, Toth Thomas L, Wright Diane L, Meeker John D and Hauser Russ . Body Mass Index in relation to semen quality, sperm DNA integrity and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril. May 1, 2010; 93: (7) 2222-2231. doi: 10.1016/j. fertnstert. 2009. 01.100.
9. Jensen TK, Andersson AM, Jørgensen N, Andersen AG, Carlsen E, Petersen JH, Skakkebaek NE. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril Oct 2004; 82(4): 863-70.
10. Pauli EM, Legro RS, Demers LM et al. Diminished paternity and gonadal function with increasing obesity in men. Fertil Steril 2008; 90: 346-51.
11. Muller M, den Tonkelaar I, ThijssenJH, Grobbee DE and van der Schouw YT. Endogenous sex hormones in men aged 40–80 years. European Journal of Endocrinology 2003; 149: 583–589.
12. Tamimi R, Mucci La, Spanos E, Lagiou A , Benetou V and Trichopoul Testosterone and Oestradiol in relation to tobacco smoking, body mass index, energy consumption and nutrient intake among adult men. Eur J Cancer Prev. June 2001; 10: (3) 275-80.
13. Schneider G, Kirschner MA, Berkowitz R, Ertel NH. Increased estrogen production in Obese men. Journal of Clinical Endocrinology and Metabolism. April 1979; 48: (4) 633-8.
14. Orwoll E, Lambert LC, Marshall LM, Phipps K, Blank J, Barrett-Connor E, Cauley J, Ensrud K and Cummings S.Testosterone and estradiol among older men. J Clin Endocrinol Metab. Apr 2006; 91(4): 1336-44. Epub 2005 Dec 20.
15. Jankowska EWA, Medras M and Rogucka EA. Body mass index, waist/hip ratio and antrogen-estrogen activity in younger versus older Polish men. Aging Male, 2000; 3: 177-84.
16. Vandenput L, Mellstrom D , Karlsson MK, Orwoll E, Labrie F , Ljunggren O , Ohlsson C . Serum estradiol is associated with lean mass in elderly Swedish men. Eur J Endocrinol. April 2010; 162(4): 737-45. Epub 2010 Jan 8.
17. Tsai E. C, Matsumoto A. M, Fujimoto W. Y & Boyko E. J. Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat. Diabetes Care 2004; 27: 861–868.
18. Strain G. W. et al. Mild hypogonadotropic hypogonadism in obese men. Metabolism. 1982; 31: 871–875.
19. de Boer H, Verschoor L, Ruinemans-Koerts J, Jansen M. Letrozole normalizes serum testosterone in severely obese men with hypogonadotropic hypogonadism. Diabetes Obes Metab. 2005; 7: 211–215.
20. Giagulli VA, Kaufman JM and Vermeulen A. Pathogenesis of the decreased androgen levels in obese men. J Clin Endocrinol Metab 1994; 79: 997–1000.
21. Aggerholm A.S, Thulstrup A.M, Toft G, Ramlau-Hansen C.H & Bonde J.P. Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile? Fertil. Steril. 2008; 90: 619-626.
22. Hammoud A.O, Gibson M, Peterson C.M, Hamilton B.D, & carell D.T. Obesity and male reproductive potential. J. Androl. 2006; 27: 619-626.
How to Cite
Ahmad E, Ahsan A, Kumar S. Correlation of Anthropometric Measurements with the Serum Total Estradiol Level in Adult Males. Int Arch BioMed Clin Res [Internet]. 2021Jul.12 [cited 2023May30];7(2):HP4-HP6. Available from:
ORIGINAL ARTICLES ~ Human Physiology