Prevalence of G6PD Deficiency and its Association with Neonatal Jaundice in Babies born at Tertiary Care Hospital
Keywords:
Glucose-6-phosphate dehydrogenase, Neonates, neonatal jaundice
Abstract
Background: G6PD deficiency is of special concern as G6PD deficiency is a known risk factor for neonatal jaundice. It has been found in meta-analysis that neonates with G6PD deficiency had three times the risk of hyperbilirubinemia and phototherapy than normal G6PD.
Materials & Methods: This case-control study included 2400 neonatal cases & 456 control. This study was conducted in Department of Pediatrics.
Results: The prevalence of G6PD Deficiency and its association with neonatal jaundice in babies born were found 1.8%.
Conclusion: This study concludes that high prevalence of neonatal jaundice amongst babies who were G6PD deficient, may lead to serious complications.
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References
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19. Pao M, Kulkarni A, Gupta V, Kaul S, Balan S (2005). Neonatal screening for glucose-6-phosphate dehydrogenase deficiency, Indian Journal of Pediatrics, 72: 835-837
2. Luzzatto L, Nannelli C, Notaro R. Glucose-6-Phosphate Dehydrogenase Deficiency. Hematol Oncol Clin North Am. 2016;30:373–393.
3. Iranpour R, Akbar MR, Haghshenas I. Glucose-6-Phosphate Dehydrogenase Deficiency in Neonates. Indian J Pediatr. 2003;70:855– 857.
4. Khan M. Glucose 6 phosphate dehydrogenase deficiency in adults. J Coll Physicians Surg Pakistan. 2004;14:400–403.
5. Eberle SE, Rosolen NG, Urtasun C, et al. Glucose 6 phosphate dehydrogenase deficiency. A case series. Arch Argent Pediatr. 2011;109(4):354–357.
6. Monteiro WM, Franca GP, Melo GC, et al. Clinical complications of G6PD deficiency in Latin American and Caribbean populations: Systematic review and implications for malaria elimination programmes. Malar J. 2014;13.
7. Liu H, Liu W, Tang X, et al. Association between G6PD Deficiency and Hyperbilirubinemia in Neonates: A Meta-Analysis. Pediatr Hematol Oncol. 2015;32(2):92–98.
8. Kaplan M, Herschel M, Hammerman C, et al. Hyperbilirubinemia among African American, glucose-6-phosphate dehydrogenase-deficient neonates. Pediatrics. 2004;114.
9. Kaplan M, Algur N, Hammerman C. Onset of jaundice in glucose-6-phosphate dehydrogenase - Deficient neonates. Pediatrics.2001;108(4):956–959.
10. Ali NA, al-Naama LM, Khalid LO (1999). Haemolytic potential of three chemotherapeutic agents and aspirin in glucose-6-phosphate dehydrogenase deficiency. Eastern Mediterranean Health Journal, 5: 457-464.
11. Dash S, Chhanhimi L, Chhakchhuak L, Zomawaia E (2005). Screening for haemoglobinopathies and G6PD deficiency among the Mizos of Mizoram: A preliminary study. Indian Journal of Pathology & Microbiology, 48:17-8.
12. 12 Bisoi S, Chakraborty S (2012) Glucose-6-Phosphate dehydrogenase screening of babies born in tertiary care hospital in west Bengal, Indian Journal of Public Health, 56(2): 146-148.
13. Flatz G, Chakravarthi MR, Dase BM and Delbrueck H (1972) Genetic survey in the population of Assam. ABO Blood groups, G-6-PD and haemoglobin type. Human Heredity, 22: 323
14. Chatterjee JB (1966), Haemoglobinopathies G-6-PD deficiency and allied problems in the Indian subcontinent. Bulletin World Health Organisation, 35: 877
15. Mondal M, Datta AK, Mandal S et al (2012) Study of Glucose-6-phosphate dehydrogenase deficiency in Neonatal Jaundice. Journal of Pharmacy and Biological Sciences, 5: 30-36.
16. Kuruvilla KA, Atanu S, Jana K (1998) Glucose-6-phosphate dehydrogenase deficiency in neonatal hyperbilirubinemia in a south Indian referral hospital. Indian Pediatrics, 35: 52-54.
17. Catherine TS, Carmencita DP, Esterlita V et al (2009) Glucose-6-Phosphate Dehydrogenase Deficiency in Filipino Neonates with Jaundice. Acta Medica Philippina, 43(2): 22-25
18. Moiz B, Amna N, Saroh AK et al (2012), Neonatal Hyperbilirubinemia in infants with G6PD c.563C > T Variant. BMC Pediatrics, 12:126
19. Pao M, Kulkarni A, Gupta V, Kaul S, Balan S (2005). Neonatal screening for glucose-6-phosphate dehydrogenase deficiency, Indian Journal of Pediatrics, 72: 835-837
Published
2018-12-29
How to Cite
1.
Dattatrayrao DP. Prevalence of G6PD Deficiency and its Association with Neonatal Jaundice in Babies born at Tertiary Care Hospital. Int Arch BioMed Clin Res [Internet]. 2018Dec.29 [cited 2023May30];4(4):95-7. Available from: https://iabcr.org/index.php/iabcr/article/view/707
Section
ORIGINAL ARTICLES ~ Paediatrics
Copyright (c) 2018 Deshmukh Prabhakar Dattatrayrao
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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