A Rare Case of Sinonasal Adenoid Cystic Carcinoma

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Authors

  • Bushra Siddiqui Assistant Professor Author
  • Surabhi Gautam Senior Resident, Department of Pathology Author
  • Aftab Ahmed Assistant Professor, Department of ENT Author
  • Mohd Feroz Alam Assistant Professor Author
  • Shahbaz Habib Faridi Assistant Professor Department of Surgery Author
  • Nainsi Gupta 5Junior Resident, Department of ENT, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India. Author

DOI:

https://doi.org/10.21276/0h4mjn21

Keywords:

Adenoid Cystic Carcinoma, nasal cavity, Immuno histochemistry

Abstract

Adenoid cystic carcinoma is primarily a tumour of salivary gland, even though it is not frequent. Moreover, it can rarely occur in other body parts, such as nose, paranasal sinuses, lungs, uterine cervix, and many others. It affects nasal cavity in about 1-2% cases with frequency twice in females than males. It may present as epistaxis, nasal obstruction, discharge, headache, facial swelling and cheek pain. Immunohistochemistry such as C-KIT (CD117) plays an important role in confirmatory diagnosis. Here we are presenting a case of 55 year old female patient who presented to ENT OPD with chief complaints of bilateral nasal obstruction since past one year with on and off episodes of epistaxis along with mild headache. Patient was evaluated and the biopsy was sent for histopathology. H and E stained sections showed fibro-collagenous tissue having foci of round blue tumour cells arranged in tubules with luminal secretions and small sheets. Further, Immuno histochemistry was performed with various markers. CD-117 came positive which confirmed our diagnosis. Adenoid Cystic Carcinoma is a rare malignancy of nasal cavity which can present as various histo-morphological types and needs IHC for confirmatory diagnosis.

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References

Dhingra H, Baliyan A, Narang S, Bala G, Gupta A. Adenoid Cystic Carcinoma of Nasal Cavity in an Adolescent Male-A Rare Presentation. Journal of Krishna Institute of Medical Sciences (JKIMSU). 2018 Apr 1;7(2).

Gandhi AK, Roy S, Biswas A, et al. Adenoid cystic carcinoma of head and neck: A single institutional analysis of 66 patients treated with multi-modality approach. Indian J Med Paediatr Oncol. 2015;36(3):166–171.

Ghani NMSNA, Shukri NM, Mohamad A. 2 case reports of sinonasal adenoid cystic carcinoma: Review of the literature on surgical approaches. Egypt J Ear, Nose, Throat Allied Sci 2016; 17(3):173-6.

Hicham J, Rachid M. Giant Adenoid cystic carcinoma of the nasal cavity. J Otol Rhinol Laryngol 2005;86:41 2

Yahaya J, Abraham Z. Adenoid cystic carcinoma of the nasal cavity—the great mimicker of chronic rhinitis: A rare case report with literature review. Case Rep Int 2019;8:100067Z06JY2019

Kim GE, Park HC, Keum KC, Lee CG, Suh CO, Hur WJ, Kim KM, Hong WP. Adenoid cystic carcinoma of the maxillary antrum. American journal of otolaryngology. 1999 Mar 1;20(2):77-84.

Thompson, L.D.R., Penner, C., Ho, N.J. et al. Sinonasal Tract and Nasopharyngeal Adenoid Cystic Carcinoma: A Clinicopathologic and Immunophenotypic Study of 86 Cases. Head and Neck Pathol 8, 88–109 (2014). https://doi.org/10.1007/s12105-013-0487-3

Persson F, Fehr A, Sundelin K, Schulte B, Löning T, Stenman G. Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. Int J Oncol 2012;40(1):80–4.

Gill KS, Fratalli MA. An unusual presentation of adenoid cystic carcinoma. Case Rep Otolaryngol 2015:1-4.

Vandenbark GR, deCastro CM, Taylor H, Dew-Knight S, Kaufman RE. Cloning and structure analysis of the human c-kit gene. Oncogene. 1992;7:1259-1266.

Michel G, Joubert M, Delemazure AS, Espitalier F, Durand N, Malard O. Adenoid cystic carcinoma of the paranasal sinuses: retrospective series and review of the literature. European Annals of Otorhinolaryngology, Head and Neck Diseases. 2013 Nov 1;130(5):257-62.

Holst VA, Marshall CE, Moskaluk CA, Frierson HF, Jr. KIT protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma. Mod Pathol 1999;12:956–60

Mino M, Pilch BZ, Faquin WC. Expression of KIT (CD117) in neoplasms of the head and neck: an ancillary marker for adenoid cystic carcinoma. Modern pathology. 2003 Dec;16(12):1224-31.

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Published

21.10.2023

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