A Rare Case of Sinonasal Adenoid Cystic Carcinoma
NONE
DOI:
https://doi.org/10.21276/0h4mjn21Keywords:
Adenoid Cystic Carcinoma, nasal cavity, Immuno histochemistryAbstract
Adenoid cystic carcinoma is primarily a tumour of salivary gland, even though it is not frequent. Moreover, it can rarely occur in other body parts, such as nose, paranasal sinuses, lungs, uterine cervix, and many others. It affects nasal cavity in about 1-2% cases with frequency twice in females than males. It may present as epistaxis, nasal obstruction, discharge, headache, facial swelling and cheek pain. Immunohistochemistry such as C-KIT (CD117) plays an important role in confirmatory diagnosis. Here we are presenting a case of 55 year old female patient who presented to ENT OPD with chief complaints of bilateral nasal obstruction since past one year with on and off episodes of epistaxis along with mild headache. Patient was evaluated and the biopsy was sent for histopathology. H and E stained sections showed fibro-collagenous tissue having foci of round blue tumour cells arranged in tubules with luminal secretions and small sheets. Further, Immuno histochemistry was performed with various markers. CD-117 came positive which confirmed our diagnosis. Adenoid Cystic Carcinoma is a rare malignancy of nasal cavity which can present as various histo-morphological types and needs IHC for confirmatory diagnosis.
Downloads
References
Dhingra H, Baliyan A, Narang S, Bala G, Gupta A. Adenoid Cystic Carcinoma of Nasal Cavity in an Adolescent Male-A Rare Presentation. Journal of Krishna Institute of Medical Sciences (JKIMSU). 2018 Apr 1;7(2).
Gandhi AK, Roy S, Biswas A, et al. Adenoid cystic carcinoma of head and neck: A single institutional analysis of 66 patients treated with multi-modality approach. Indian J Med Paediatr Oncol. 2015;36(3):166–171.
Ghani NMSNA, Shukri NM, Mohamad A. 2 case reports of sinonasal adenoid cystic carcinoma: Review of the literature on surgical approaches. Egypt J Ear, Nose, Throat Allied Sci 2016; 17(3):173-6.
Hicham J, Rachid M. Giant Adenoid cystic carcinoma of the nasal cavity. J Otol Rhinol Laryngol 2005;86:41 2
Yahaya J, Abraham Z. Adenoid cystic carcinoma of the nasal cavity—the great mimicker of chronic rhinitis: A rare case report with literature review. Case Rep Int 2019;8:100067Z06JY2019
Kim GE, Park HC, Keum KC, Lee CG, Suh CO, Hur WJ, Kim KM, Hong WP. Adenoid cystic carcinoma of the maxillary antrum. American journal of otolaryngology. 1999 Mar 1;20(2):77-84.
Thompson, L.D.R., Penner, C., Ho, N.J. et al. Sinonasal Tract and Nasopharyngeal Adenoid Cystic Carcinoma: A Clinicopathologic and Immunophenotypic Study of 86 Cases. Head and Neck Pathol 8, 88–109 (2014). https://doi.org/10.1007/s12105-013-0487-3
Persson F, Fehr A, Sundelin K, Schulte B, Löning T, Stenman G. Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. Int J Oncol 2012;40(1):80–4.
Gill KS, Fratalli MA. An unusual presentation of adenoid cystic carcinoma. Case Rep Otolaryngol 2015:1-4.
Vandenbark GR, deCastro CM, Taylor H, Dew-Knight S, Kaufman RE. Cloning and structure analysis of the human c-kit gene. Oncogene. 1992;7:1259-1266.
Michel G, Joubert M, Delemazure AS, Espitalier F, Durand N, Malard O. Adenoid cystic carcinoma of the paranasal sinuses: retrospective series and review of the literature. European Annals of Otorhinolaryngology, Head and Neck Diseases. 2013 Nov 1;130(5):257-62.
Holst VA, Marshall CE, Moskaluk CA, Frierson HF, Jr. KIT protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma. Mod Pathol 1999;12:956–60
Mino M, Pilch BZ, Faquin WC. Expression of KIT (CD117) in neoplasms of the head and neck: an ancillary marker for adenoid cystic carcinoma. Modern pathology. 2003 Dec;16(12):1224-31.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 International Archives of BioMedical and Clinical Research (IABCR)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors are required to sign and submit the completed “Copyright transfer Form” upon acceptance of publication of the paper. This is determined by a publishing agreement between the author and International Archives of Biomedical and Clinical Research. These rights might include the right to publish, communicate and distribute online. Author(s) retain the copyright of their work. International Archives of Biomedical and Clinical Research supports the need for authors to share, disseminate and maximize the impact of their research.
