A Hospital Based Observational Study to Evaluate the Efficacy of Melatonin in Preventing Postoperative Delirium and Decreasing Analgesic Requirement in Lower Limb Surgery Performed Under Spinal Anaesthesia in Geriatric Patients

  • Ratan Lal Yadav Senior Resident, Department of Anaesthesia, Jawahar Lal Nehru Medical college, Ajmer, Rajasthan, India.
  • Richa Singh Senior Resident, Department of Anaesthesia, Jawahar Lal Nehru Medical college, Ajmer, Rajasthan, India.
  • Deepika Meena Assistant Professor, Department of Anaesthesia, Jawahar Lal Nehru Medical college, Ajmer, Rajasthan, India. Lal Nehru Medical college, Ajmer, Rajasthan, India.
Keywords: Delirium, Melatonin, Placebo, sedation

Abstract

Background:Delirium leads to acute and fluctuating disturbance in mental state leading to reduction in awareness and attention disturbance. Medications is most common reversible cause of delirium. The aim of this study to evaluate the efficacy of melatonin in preventing postoperative delirium and decreasing analgesic requirement in lower limb surgery performed under spinal anaesthesia in geriatric patients.

Methods: A Hospital based observational study done on 50 patients divided in two groups: Group P (N=25) & Group M (N=25) in Department of Anaesthesiology, Jawahar Lal Nehru Medical College and Hospital, Ajmer, Rajasthan. In the recovery room sedation score and Abbreviated mental test {AMT} was noted prior to administration of morning dose of melatonin.AMT repeated on the same day of operation (POD-0) and in the three postoperative days (POD) followed (POD-1, POD-2 and POD-3).

Results: The present study showed that the mean age of patients was 66.23±8.62 in group P and 67.48±8.13 years in group M but statistical non-significant (p>0.05). The sedation score in group P and group M was statistically non-significant (P=0.7111 NS) at baseline but statistically significant (p<0.05 & p<0.05 respectively) at 60 minutes and after 130 minutes. The melatonin group differed significantly compared with group P, having less number of patients developed delirium.

Conclusion: We concluded that many of patients if left unattended may develop postoperative delirium.  Melatonin was helpful in treating and preventing postoperative delirium.

 

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Published
2021-03-30
How to Cite
1.
Yadav RL, Singh R, Meena D. A Hospital Based Observational Study to Evaluate the Efficacy of Melatonin in Preventing Postoperative Delirium and Decreasing Analgesic Requirement in Lower Limb Surgery Performed Under Spinal Anaesthesia in Geriatric Patients. Int Arch BioMed Clin Res [Internet]. 2021Mar.30 [cited 2021May9];7(1):AN1-AN3. Available from: https://iabcr.org/index.php/iabcr/article/view/699
Section
ORIGINAL ARTICLES ~ Anaesthesiology