Epidemiology of Type 1 Bipolar Disorder and Associated Personality Traits in a Tertiary Level Psychiatry Centerorder and Associated Personality Traits in a Tertiary Level Psychiatry Center

  • JK Verma Assistant Professor, MRA Medical C1Assistant Professor, MRA Medical College Ambedkarnagar
  • Anurag Agrawal Associate Professor, Integral Institute of Medical Science And Research, Lucknow.
Keywords: Bipolar 1 disorder, Epidemiology, Personality Traits


Background:Bipolar disorders are frequently associated with diverse Axis I psychiatric co- morbidities and Axis II personality disorders which affect treatment strategies and outcome in such patients. Present study was undertaken with the aim to study regarding Epidemiology and associated personality traits in patients of Bipolar 1 disorder in full remission.

Methods: This was a single point cross-sectional study of patients of Bipolar 1 disorder in remission attending a Tertiary level Psychiatry Center; to assess Epidemiology of Type 1 Bipolar Disorder and associated Personality Traits by using appropriate tools.

Results: Total study sample was 107. The mean age of onset, mean number of episodes, mean duration of affective episode and mean duration of inter episodic symptom free period was 22.68±2.95 years, 4.34±2.35, 2.88 ± 2.03 months and 2.14 ± 1.96 years respectively for the total sample. Mean number of episodes was 5.33±2.72 for Axis II disorder group. Mania was the first episode in 82.24% patients. 22.43% subjects were diagnosed with Axis II disorder while 42.99% subjects had axis II traits. 70.83% of the patients with axis II disorder had a history of suicidal ideation as compared to 40.54% of patients without any axis II disorder/trait.

Conclusion: Mean age of onset of Bipolar 1 disorder was in early twenties with Mania being much more common. Presence of comorbid axis II disorders and traits led to increased duration and number of affective episodes as compared to those without any co-morbid axis II disorder/trait. Suicidal behaviour was frequent even more in the patients with comorbid axis II disorders.



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1. Demyttenaere, K., Bruffaerts, R., Posada-Villa, J., et al (2004). Prevalence, severity and unmet need for treatment of mental disorders in the World Health Organization, World Mental Health Surveys. JAMA 291: 2581-90.
2. US Dept Health and Human Services, National Institute of Mental Health. Epidemiologic catchment area (ECA) survey of mental disorders, wave I (household), 1980-1985: [United States]. 2002; ICPSR 8993:1-911. Inter-university Consortium for Political and Social Research.
3. Kessler RC, Rubinow DR, Holmes C, et al. The epidemiology of DSM-III-R bipolar I disorder in a general population survey. Psychol Med. 1997;27(5):1079-1089.
4. Kessler RC, Berglund P., Demler, O., et al. (2005). Life-time prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:593-602.
5. Marangell LB, Bauer MS, Dennehy EB, et al. Prospective predictors of suicide and suicide attempts in 1,556 patients with bipolar disorders followed for up to 2 years. Bipolar Disord2006;8:566-575.
6. Dunayevich E, Sax KW, Keck PE et al. Twelve- month outcome in bipolar patients with and without personality disorders. J Clin Psychiatry 2000; 61: 134-139.
7. George EL, Miklowitz DJ, Richards JA, Simoneau TL, Taylor DO. The comorbidity of bipolar disorder and axis II personality disorders: prevalence and clinical correlates. Bipolar Disorders 2003: 5: 115-122.
8. Altindag A, Yanik M, Nebioglu M. Comorbid personality disorders in subjects with bipolar I disorder. Inter J Psychiatry Clin Practice, 2006; 10: 33-37.
9. First, MB., Spitzer, Robert L, Gibbon Miriam, and Williams, Janet B.W. Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Edition (SCID-I/P). Washington DC: American Psychiatric Press, Inc., 1996.
10. First MB., Gibbon M, Spitzer RL, Williams JBW, Benjamin LS.: Structured Clinical Interview for DSM-IV Axis II Personality Disorders, (SCID-II). Washington, DC.: American Psychiatric Press, Inc., 1997.
11. American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders, 4thedn, text revision (DSM IV-TR). Washington, DC: American Psychiatric Association.
12. Varma S, Singh H, Trivedi JK, Agarwal V.Axis I psychiatric co-morbidities in patients of bipolar I disorders in depression or remission(2010).department of psychiatry CSMMU, UP, Lucknow.
13. Chopra MP, Kishore Kumar KV, Subbakrishna DK, Jain S,Srinivasa Murthy R (2006). The course of bipolar disorder in rural area. Indian Journal of Psychiatry 48; 254-257.
14. Morken G, Vaaler AE, Folden GE, Andreassen OA, UFMalt. Age at onset of first episode and time to treatment in in-patients with bipolar disorder. BJP 2009;194:559-560.
15. Peh A L H, Tay L K. Demographical profile and clinical features of patients with bipolar disorder in an outpatient setting in Singapore. Singapore Med J2008;49(5):380.
16. Dunayevich E, Strakowski SM, Sax KW et al. Personality disorders in first and multiple episode mania. Psychiatr Res 1996; 64: 69-75.
17. Perugi G, Micheli C, Akiskal HS, Madaro D, Socci C, Quilici C, Muserri I. Polarity of the first episode, clinical characteristics, and course of manic depressive illness : a systematic retrospective investigation of 320 bipolar I patients. Comprehensive Psychiatry. 2000, vol. 41, n01, pp. 13-18.
18. Daban C, Colom F, Sanchez-Moreno J, Garcia-Amador M, Vieta E. Clinical correlates of first-episode polarity of bipolar disorder. Compr Psychiatry. 2006 Nov-Dec; 47(6):433-7.
19. Garno JL, Goldberg JF, Ramirez PM, Ritzler BA. Bipolar disorder with comorbid cluster B personality disorder features: impact on suicidality. J Clin Psychiatry. 2005 Mar;66(3):339-45
20. Leverich GS; Altshuler LL; Frye MA; et al. Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network. J Clin Psychiatry;2003 May 64(5):506-15.
21. Valtonen H, Suominen K, Mantere O. Suicidal ideations and attempts in bipolar I and II disorders. J Clin psychiatry; 2005; 66:1456-1462.
22. Keck PE Jr, McElroy SL, Havens JR, Altshuler LL. Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness. Compr Psychiatry. 2003 Jul-Aug;44(4)263-9.
23. Kay JH, Altshuler LL, Ventura J, Mintz J. Impact of axis II comorbidity on the course of bipolar illness in men: a retrospective chart review Bipolar Disord. 2002 Aug;4(4):237-42.
24. Akiskal HS, Hirschfeld RM, Yerevanian BJ. The relationship of personality to affective disorders. Arch Gen Psychiatry 1983; 40: 801-810.
25. Vieta E, Colom F, Martinez-Aran X, Benabarre X, Reinares M, Gasto C. Bipolar II disorder and comorbidity. Compr Psychiatry 2000;41: 339-43.
26. Smith DJ, Muir WR, Blackwood DH. Is borderline personality disorder part of the bipolar spectrum? Harv Rev Psychiatry. 2004 May-Jun;12(3):133-9.
27. Gunderson JG, Weinberg I, Daversa MT, Kueppenbender KD et al. Descriptive and longitudinal observations on the relationship of borderline personality disorder and bipolar disorder. Am J Psychiatry. 2006 Jul; 163(7):1173-8.
28. Paris J, Gunderson J, Weinberg I. The Interface between borderline personality disorder and bipolar spectrum disorders. Compr Psychiatry. 2007 Mar; 48(2):145-54.
29. O’Connell RA, Mayo JA, Sciutto MS. PDQ-R personality disorders in bipolar patients. J Affect Disord 1991; 23: 217-221.
30. Barbato N, Hafner RJ. Comorbidity of bipolar and personality disorder. Austr New Zeal J Psychiatry 1998; 32: 276-280.
31. Turley B, Bates GW, Edwards J, Jackson HJ. MCMI-II diagnosis in recent onset bipolar disorders. J Clin Psychol 1992; 48: 320-329.
How to Cite
Verma J, Agrawal A. Epidemiology of Type 1 Bipolar Disorder and Associated Personality Traits in a Tertiary Level Psychiatry Centerorder and Associated Personality Traits in a Tertiary Level Psychiatry Center. Int Arch BioMed Clin Res [Internet]. 2021Mar.30 [cited 2021May9];7(1):PS1-PS5. Available from: https://iabcr.org/index.php/iabcr/article/view/692