A Prospective Study on Use of Teriparatide and Zoledronic Acid in Cases of Osteoporosis
DOI:
https://doi.org/10.21276/np98f294Keywords:
Teriparatide, Zoledronic Acid, OsteoporosisAbstract
Background: Present prospective study is intended to compare role of Teriparatide and Zoledronic acid in osteoporosis as well as in pathological fracture due to osteoporosis so as to help elderly postmenopausal women to combat with osteoporosis & complications arising due to it.
Methods: This study is carried out in the department of orthopedics. Total of 100 women were included at the time of beginning but 20 women were lost in the follow up due to various reasons
Results: 51 patients of group 1 were given Zoledronic acid & 29 patients were given Teriparatide. Patients were evaluated up to 12 months at regular intervals. Serial DEXA scans were done, assessment & comparison were done accordingly.
Conclusions: Treatment of osteoporosis is multimodal with no definitive single molecule available. This study compared Zoledronic acid & Teriparatide. Although T-score has nearly the same value, but our study resulted in increased BMD score & fewer side effects by the use of Teriparatide, so it is concluded that patient with very low BMD requires treatment with Teriparatide.
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References
Meenal Jain et al IJMHS.net July 2017 –A prospective comparative study
of efficacy of Zoledronic acid vs Teriparatide on BMD via Dexa scan in
postmenopausal osteoporosis.
Cosman F, Eriksen Ef et al –effects of IV Zoledronic acid plus
subcutaneous Teriparatide in postmenopausal osteoporosis. J Bone
Mineral Res.2011;26:503-511 [Pubmed].
Cosman F, Nieves J, Zion M, Woelfert L , Luckey M. et al –Daily & cyclic
parathyroid hormone in women receiving Alendronate .N Engl J
Med.2005;353,566-575. [Pubmed].
Black DM, Greenspan SL, Ensurd KE et al –The effects of parathyroid
hormone & alendronate alone or in combination in postmenopausal
osteoporosis, N Engl J Med 2003;349:1207-1215.[Pubmed].
Neer RM, Arnaud CD, Zanchetta JR et al- Effect of parathyroid hormone
on fractures & BMD in postmenopausal women with osteoporosis. N
Engl J Med.2001;344:1434-1441. [Pubmed].
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