Prevalence of Colorectal Malignancy in Patients of Early Age-Group – A Hospital Based Prospective Study
Background: : Colorectal cancers being one of the leading causes of cancer related deaths in the world. Earlier it was thought that the colorectal cancers usually occur in older age groups. This thought has led to decrease in chances of malignancy in young patients. Therefore, we conducted this study of colorectal cancers in young patient to emphasise the importance of keeping in entity in mind while dealing with the patient presenting with complaints consistent with colorectal malignancy even if there age is less than forty year. Methods This study was a prospective cohort study of 30 cases of colorectal malignancy of age 40 years and below conducted in patients admitted in Department of Surgery at FH Medical College & Hospital, Tundla (UP), Firozabad, U.P. Results: In this study of colorectal cancers in young patient maximum number of patients were found in the age group of 31-40 years (70.4%) followed by in the age group of 21-30 years (27.57%)and 11-20 years (2.58%). Males were found to be affected more (59.76%) than females (41.23%). Most common site of involvement was found to be rectum (59.24%) followed by rectosigmoid (15.36%), caecum and descending colon (10.20%). Most common sign was found to be bleeding per rectum (71.24%) and most common symptom was found to be altered bowel habits (53%) followed by pain abdomen (62.58%). Mucinous adenocarcinoma (54.68%) was found to be most common histological type of colorectal malignancy followed by adenocarcinoma (46.35%). Conclusions: Our study was aimed at analysing colorectal malignancy in young patients. It should promote high index of suspicion on the part of treating surgeons about this entity even in young patients.
2. World Health Organization Cancer Incidence in Five Continents. Lyon: The World Health Organization and The International Agency for Research on Cancer; 2002.
3. Ries L AG, Melbert D, Krapcho M, et al. SEER cancer statistics review, 1975–2005. Bethesda, MD: 2008
4. Sanfelippo PM, Beahrs OH. Carcinoma of the colon in patients under forty years of age. Surg Gynecol Obstet 1974; 138:169–70.
5. Kern WH, White WC. Adenocarcinoma of the colon in a 9-month-old infant; report of a case. Cancer. 1958 Jul-Aug;11(4):855–857.
6. Pemberton M (1970) Carcinoma of the large intestine with survival in a child of nine and in his father. A study of carcinoma of the colon with particular reference to children. Br J Surg 57(11):841–846.
7. Young CJ, Sweeney JL, Hunter A. Implications of delayed diagnosis in colorectal cancer. Aust N Z J Surg. 2000 Sep;70(9):635-8.
8. Fu J-F, Huang Y-Q, Yang J, Yi C-H, Chen H-L, Zheng S. Clinical characteristics and prognosis of young patients with colorectal cancer in Eastern China. World Journal of Gastroenterology: WJG. 2013;19(44):8078-8084.
9. Fu J, Yang J, Tan Y, et al. Young Patients (≤35years old) With Colorectal Cancer Have Worse Outcomes Due to More Advanced Disease: A 30-Year Retrospective Review. Gotthardt D, ed. Medicine. 2014;93(23):e135.
10. Hadar GoldvaserOfer PurimYulia KundelDaniel ShepshelovichTzippy ShochatLital Shemesh-BarAaron Sulkes Colorectal cancer in young patients: is it a distinct clinical entity?J Clin Oncol (2016) 21: 684.
11. Boyle P, Langman J S. ABC of colorectal cancer: Epidemiology. BMJ. 2000;321(7264):805– 808.
12. Jemal A, Clegg L X, Ward E, et al. Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival. Cancer. 2004;101(1):3–27.
13. Ries L AG, Melbert D, Krapcho M, et al. SEER cancer statistics review, 1975–2005. Bethesda, MD: 2008.
14. O'Connell J B, Maggard M A, Livingston E H, Yo C K. Colorectal cancer in the young. Am J Surg. 2004;187(3):343–348.
15. Giovannucci E. Modifiable risk factors for colon cancer. Gastroenterol Clin North Am. 2002 Dec;31(4):925-43.
16. Reddy BS. Types and amount of dietary fat and colon cancer risk: Prevention by omega-3 fatty acid-rich diets. Environmental Health and Preventive Medicine. 2002;7(3):95-102.
17. Santarelli R L, Pierre F, Corpet D E. Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence. Nutr Cancer. 2008;60(2):131–144.
18. Phipps AI, Lindor NM, Jenkins MA, et al. Colon and Rectal Cancer Survival by Tumor Location and Microsatellite Instability: The Colon Cancer Family Registry. Diseases of the colon and rectum. 2013;56(8):937-944.
Copyright (c) 2017 International Archives of BioMedical and Clinical Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.