High Sensitivity C - Reactive Protein and Insulin Resistance in Women with Polycystic Ovary Syndrome
Background: Polycystic Ovary Syndrome (PCOS) characterised by anovulation, polycystic ovaries and hyperandrogenism also leads to metabolic abnormalities such as insulin resistance (IR), deranged lipid profile, hypertension and a low-grade chronic inflammation. These factors are known to increase risk for cardiovascular diseases. This study aimed to compare various biochemical parameters between women with PCOS and age matched healthy controls.
Methods: Total 80 women diagnosed with PCOS were investigated for fasting plasma glucose, serum insulin, Insulin resistance (homeostasis model assessment, HOMA-IR), and hs-CRP and compared with 40 apparently healthy women. Cases of PCOS were divided in two groups based on BMI: PCOS with BMI 18.5 – 24.99 kg/m2 and PCOS with BMI ≥ 25 kg/m2.
Results: Serum insulin levels and HOMA-IR values were significantly (p<0.05) higher in women with PCOS than controls. Levels of hs-CRP were also significantly higher in women with PCOS as compared to controls.
Conclusions: Early recognition of risk factors for cardiovascular disease in PCOS women is important from clinical and public health perspective.
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