Association Between Carotid Intima Medial Thickness and Dyslipidemia

  • Malay Acharyya Department of Cardiology, Midnapore Medical College and Hospital, Kolkata, India.
Keywords: Carotid intima medial thickness, Dyslipidemia, Blood parameters, Atherosclerosis


Background: Objective:  The objective was to know the association between carotid intima medial thickness (CIMT) and dyslipidemia.

Methods: The study was carried out in a tertiary care hospital in Kolkata. Total 100 patients were selected randomly who met the inclusion criteria. Among total patients, 48 were males and 52 were females. CIMT was measured by carotid artery ultrasonography using an echo tomography system having midfrequency of 7.5MhZ and detection limit of 0.1mm. The blood parameters such as LDL, HDL, total cholesterol, triglyceride and VLDL were estimated by using laboratory technique. Data was collected using a predetermined proforma and statistical analyses were done.

Results: Both common carotid artery IMT and internal carotid artery IMT was increased in a step wise fashion with raising tertiles of LDL (P<0.01) and total cholesterol (P<0.01). There was decreasing trend in both CCA-IMT and ICA IMT with increasing tertiles of HDL (P<0.01). No direct correlation was found between CCA-IMT and ICA-IMT with either VLDL or TG. The mean CIMT was significantly higher in hypertensive subjects than in non-hypertensive subjects. (P<0.004). Mean CIMT was significantly higher in current smokers than in non-smokers (P<0.001).

Conclusions: CIMT is an objective measure of subclinical atherosclerosis, which is a non- invasive, less expensive and time taking and easy reproducible way of demonstrating subclinical atherosclerosis. Thus, it can serve as a window for atherosclerosis status in other major arteries like coronary artery and cerebral arteries. The CIMT is closely associated with dyslipidemia, which can only be identified through specific blood parameters.


Download data is not yet available.


1. Peters SA, Bots ML. Carotid intima-media thickness studies: study design and data analysis. Journal of Stroke. 2013;15(1):38-48.
2. Abd alamir M, Goyfman M, Chaus A, Dabbous F, Tamura L, Sandfort V, et al. The correlation of dyslipidemia with the extent of coronary artery disease in the multiethnic study of atherosclerosis. Journal of Lipids. 2018; 2018: Article ID 5607349.
3. Bond MG, Barnes RW, Riley WA, Wilmoth SK, Chambless LE, Howard G. et al. High‐resolution B‐Mode ultrasound scanning methods in the atherosclerosis risk in communities study (ARIC). Journal of Neuroimaging. 1991;1:68-73.
4. Pignoli P, Tremoli E, Pli A, Oreste P, Paoletti R. A direct measurement of intima plus medial thickness of the arterial wall by ultrasound imaging. Circulation. 1986;74(6):1399-1406.
5. Pignoli P. Ultrasonography B mode imaging for arterial wall thickness measurement. Atherosclerosis Review. 1984;12:177-189.
6. Jadhav UM, Kadam NN. Association of microalbuminuria with carotid
intima-media thickness and coronary artery disease – A cross-sectional study in western India. Journal of the Association of Physicians of India. 2002;50:1142-1149.
7. Acharyya M, Haldar SK. Carotid intima medial thickness as a surrogate marker for systemic atherosclerosis in type 2 diabetes mellitus. International Archives of Biomedical and Clinical Research. 2019;5(2):23-27.
8. Friendewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein in plasma, without use of preparative ultracentrifuge. Clin Chem. 1972;18:499-502.
9. de Groot E, Hovingh GK, Wiegman A, Duriez P, Smit AJ, Fruchart JC, et al. Measurement of arterial wall thickness as a surrogate marker for atherosclerosis. Circulation. 2004;109:III33-III38.
10. Jacoby DS, Mohler III ER, Rader DJ. Noninvasive atherosclerosis imaging for predicting cardiovascular events and assessing therapeutic interventions. Curr Atheroscler Rep. 2004;6:20-26.
11. Puato M, Palatini P, Zanardo M, Dorigatti F, Tirrito C, Rattazzi M, et al. Increase in carotid intima-media thickness in grade I hypertensive subjects. Hypertension. 2008;51:1300-1305.
12. Kumar A, Kulshrestha M, Tripathi A, Sharma M, Kartikeya. A study of correlation between carotid intima – media thickness and diastolic dysfunction in asymptomatic type 2 diabetes mellitus. International Journal of Contemporary Medical Research. 2016;3(5): 1458-1461.
13. Kawamori R, Yamasaki Y, Matsushima H, Nishizawa H, Nao K, Hougaku H, et al. Prevalence of carotid atherosclerosis in diabetic patients. Diabetes Care. 1992;15:1290-1294.
14. Fan AZ, Paul-Labrador M, Merz CNB, Iribarren C, Dwyer JH. Smoking status and common carotid artery intima-medial thickness among middle-aged men and women based on ultrasound measurement: a cohort study. BMC Cardiovascular Disorders. 2006;6:42.
15. Kiechl S, Werner P, Egger G, Oberhollenzer F, Mayr M, Xu O, et al. Active and passive smoking, chronic infections, and the risk of carotid atherosclerosis. Stroke. 2002;33:2170-2176.
16. Lee EJ, Kim HJ, Bae JM, Kim JC, Han HJ, Park CS, et al. Relevance of common carotid intima-media thickness and carotid plaque as risk factors for ischemic stroke in patients with type 2 diabetes mellitus. American Journal of Neuroradiology. 2007; 28(5):916-919.
How to Cite
Acharyya M. Association Between Carotid Intima Medial Thickness and Dyslipidemia . Int Arch BioMed Clin Res [Internet]. 2019Dec.24 [cited 2020Sep.18];5(4):GM1-GM5. Available from:
ORIGINAL ARTICLES ~ General Medicine