Association Between Carotid Intima Medial Thickness and Dyslipidemia
Background: Objective: The objective was to know the association between carotid intima medial thickness (CIMT) and dyslipidemia.
Methods: The study was carried out in a tertiary care hospital in Kolkata. Total 100 patients were selected randomly who met the inclusion criteria. Among total patients, 48 were males and 52 were females. CIMT was measured by carotid artery ultrasonography using an echo tomography system having midfrequency of 7.5MhZ and detection limit of 0.1mm. The blood parameters such as LDL, HDL, total cholesterol, triglyceride and VLDL were estimated by using laboratory technique. Data was collected using a predetermined proforma and statistical analyses were done.
Results: Both common carotid artery IMT and internal carotid artery IMT was increased in a step wise fashion with raising tertiles of LDL (P<0.01) and total cholesterol (P<0.01). There was decreasing trend in both CCA-IMT and ICA IMT with increasing tertiles of HDL (P<0.01). No direct correlation was found between CCA-IMT and ICA-IMT with either VLDL or TG. The mean CIMT was significantly higher in hypertensive subjects than in non-hypertensive subjects. (P<0.004). Mean CIMT was significantly higher in current smokers than in non-smokers (P<0.001).
Conclusions: CIMT is an objective measure of subclinical atherosclerosis, which is a non- invasive, less expensive and time taking and easy reproducible way of demonstrating subclinical atherosclerosis. Thus, it can serve as a window for atherosclerosis status in other major arteries like coronary artery and cerebral arteries. The CIMT is closely associated with dyslipidemia, which can only be identified through specific blood parameters.
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