A Prospective Study on Postmenopausal Type 2-Diabetic Women Suffering from Knee Osteoarthritis in a Tertiary Care Teaching Hospital
Background: Knee osteoarthritis is the most common form of joint disorder and a leading cause of pain and functional disability among elderly female population. Type 2-diabetes is frequently reported comorbidity in elderly female patients with knee osteoarthritis. Therefore, the aim of this study is to assess the role of various blood biochemical parameters in cases of knee osteoarthritis among type 2 diabetic postmenopausal women. Methods: The present study conducted in the Department of Orthopaedics, Pacific Medical College and Hospital, Udaipur, Rajasthan. 55 type 2-diabetic female subjects of age above 50 years were enrolled as cases and 55 normal healthy female age matched individuals as controls. Osteoarthritis of knee was ascertained using the American college of rheumatology classification criteria. Results: The mean levels of fasting blood sugar, HbA1c, total cholesterol, TG, LDL-C and VLDL-C were also found significantly increased while HDL-C was found significantly decreased in cases as compared to controls. Conclusions: We concluded that there is a positive correlation with increased levels of HbA1c and FBS (p˂0.001) in diabetic postmenopausal women and knee osteoarthritis.
2. Akinpelu AO, Alonge TO, Adekanla BA, Odole AC. Prevalence and pattern of symptomatic knee osteoarthritis in Nigeria: A community-based study. Internet J Allied Health Sci Pract. 2009;7(3):1-7.
3. Davis MA, Ettinger WH, Neuhaus JM, Hauck WW. Sex differences in osteoarthritis of the knee. The role of obesity. Am J Epidemiol. 1988;127(5):1019-30.
4. Solomon L, Beighton P, Lawrence JS. Rheumatic disorders in the South African Negro. Patrt II. Osteo-arthrosis. S Afr Med J. 1975;49(32):1737-40.
5. Dasgupta D, Ray S. Menopausal Problems Among Rural and Urban Women from Eastern India. J Soc Behav Health Sci. 2009;3(1):20-33.
6. Dratva J, Gomez Real F, Schindler C, Ackermann-Liebrich U, Gerbase MW, Probst-Hensch NM, et al. Age at menopause increasing across Europe? Results on age at menopause and determinants from two population-based studies. Menopause. 2009;16(2):385-94.
7. Mahajan A, Tandon V, Verma S, Sharma S. Osteoarthritis and menopause. J Indian Rheumatol Assoc. 2005;13:21-5.
8. Roman-Blas JA, Castaneda S, Largo R, Herrero-Beaumon G. Osteoarthritis associated with estrogen deficiency. Arthritis Res Ther. 2009;11:241.
9. Crispin JC, Alcocer-Varela J. Rheumatologic manifestations of diabetes mellitus. Am J Med. 2003;114:753-7.
10. Arkkila PE, Gautier JF. Musculoskeletal disorders in diabetes mellitus: an update. Best Pract Res Clin Rheumatol. 2003;17:945-70.
11. Swierkot J, Guszecka-Marczynska K, Sowinsk D, Szechinski J. Rheumatic disorders in diabetes mellitus. Pol Merkur Lekarski. 2005;19:843-7.
12. Del Rosso A, Cerinic MM, De Giorgio F, Minari C, Rotella CM, Seghier G. Rheumatological manifestations in diabetes mellitus. Curr Diabetes Rev. 2006;4:455-66.
13. Douloumpakas I, Pyrpasopoulou A, Triantafyllou A, Sampanis CH, Aslanidis S. Prevalence of musculoskeletal disorders in patients with type 2 diabetes mellitus: a pilot study. Hippokratia. 2007; 4:216-8.
14. Burner TW, Rosenthal AK. Diabetes and rheumatic diseases. Curr Opin Rheumatol. 2009;21:50-4.
15. Berenbaum F. Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype. Ann Rheum Dis. 2011;70(8):1354-6.
16. Berenbaum F. Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype. Ann Rheum Dis. 2011;70:1354-
17. Cimmino MA, Cutolo M. Plasma glucose concentration in symptomatic osteoarthritis: a clinical and epidemiological survey. Clin Exp Rheumatol. 1990;8:251-7.
18. Rouen PA, Krein SL, Nancy E. Reame NE. Postmenopausal symptoms in female veterans with type 2 diabetes: glucose control and symptom severity. J Womens Health Larchmt. 2015;24(6):496-505.
19. Hart DJ, Doyle DV, Spector TD. Association between metabolic factors and knee osteoarthritis in women: the Chingford Study. J Rheumatol. 1995;22:1118-23.
Copyright (c) 2017 International Archives of BioMedical and Clinical Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.