A Comparative Study on General Anaesthetics: Sevoflurane Versus Halothane in Paediatrics Patients
Background: In pediatric patients, induction and maintenance of anesthesia can be done using inhalational method or intravenous method. Though, absence of intravenous access in these patients makes inhalational anesthesia the commonly used modality. In pediatric patients, sevoflurane and halothane are both inhalational anesthetic agents used for general anesthesia.
Methods: This study was conducted in the Department of Anesthesia in Krishna Mohan Medical College & Hospital, Mathura, U.P, India.. The duration of study was over a period of six month.
Result: The difference was statistically significant (P value <0.05). The mean intubation time was significantly lower in group-A (226.37±14.23 sec) in comparison to group-B (281.33±7.01). The emergence time was also significantly lower in group-A (237.97±11.36 sec) in comparison to group-B (373.70±14.54 sec).
Conclusion: This study concludes that rapid recovery in sevoflurane group in comparison to halothane group. Therefore, tis study found that in children for smooth and faster induction and early recovery, sevoflurane is a safe inhalation induction agent than halothane without causing any adverse effect.
2. Kenna JG, Neuberger J, Mieli-Vergani G, et al. Haiothane hepatitis in children. Br Med J. 1987;294:1209-1211.
3. Walton B. Halothane hepatitis in children [editorial]. Anaesthesia. 1986;41:575-578.
4. Malviya S, Lerman J. The blood/gas solubilities of sevoflurane, isoflurane, halothane, and serum constituent concentrations in neonates and adults. Anesthesiology. 1990;72:793-796.
5. Holaday DA, Smith FR. Clinical characteristics and biotransformation of sevoflurane in healthy human volunteers. Anesthesiology. 1981;54:100-106
6. Brown EN, Lydic R, Schiff ND. General anesthesia, sleep, and coma. New England Journal of Medicine. 2010 Dec 30;363(27):2638-50.
7. Lee SY, Cheng SL, Ng SB, Lim SL. Single-breath vital capacity high concentration sevoflurane induction in children: with or without nitrous oxide?. British journal of anaesthesia. 2012 Sep 17; 110(1):81-6.
8. Goresky GV, Muir J. Inhalation induction of anaesthesia.cana j of anaesthesia 1996; 43:1085-89
9. Muzi M, Robinson BJ, Ebert TJ, O'brien TJ. Induction of anesthesia and tracheal intubation with sevoflurane in adults. The Journal of the American Society of Anesthesiologists. 1996 Sep 1;85(3):536-43.
10. Epstein RH, Mendel HG, Guarnieri KM, Staudt SR, Lessin JB, Marr AT. Sevoflurane versus halothane for general anesthesia in pediatric patients: a comparative study of vital signs, induction, and emergence. Journal of clinical anesthesia. 1995 May 1;7(3):237-44.
11. Wappler F, Frings DP, Scholz J, Mann V, Koch C, am Esch JS. Inhalational induction of anaesthesia with 8% sevoflurane in children: conditions for endotracheal intubation and side-effects. European journal of anaesthesiology. 2003 Sep;20(7):548-54.
12. Lerman J, Sikich N, Kleinman S, Yentis S. The pharmacology of sevoflurane in infants and children. Anesthesiology. 1994 Apr;80(4):814-24.
13. Naito Y, Tamai S, Shingu K, Fujimori R, Mori K. Comparison between sevoflurane and halothane for paediatric ambulatory anaesthesia. BJA: British Journal of Anaesthesia. 1991 Oct 1;67(4):387-9.
14. Morgan GE, Mikhail MS, Murray mj. peadiatric anaesthesia clinical anaesthesiology. 4thedition. Medical publishing division, newyork, 06p934-935.
15. Sigston PE, Jenkins AM, Jackson EA, Sury MR, Mackersie AM, Hatch DJ. Rapid inhalation induction in children: 8% sevoflurane compared with 5% halothane. British journal of anaesthesia. 1997 Apr 1;78(4):362-5.
16. Katoh T, Ikeda K. The minimum alveolar concentration (MAC) of sevoflurane in humans. Anesthesiology. 1987 Mar;66(3):301-3.
17. Dedhia KN, Kudalkar A. Comparison of Sevoflurane and Halothane for induction of anesthesia and laryngeal mask airway insertion in pediatric patients. Indian J Anaesth.2004 Dec;48(6):465-8.
18. Strum DP, Eger EI. Partition coefficients for sevoflurane in human blood, saline, and olive oil. Anesthesia & Analgesia. 1987 Jul 1;66(7):654-6.
19. Redhu S, Jalwal GK, Saxena M, Shrivastava OP. A comparative study of induction, maintenance and recovery characteristics of sevoflurane and halothane anaesthesia in pediatric patients (6 months to 6 years). Journal of anaesthesiology, clinical pharmacology. 2010 Oct;26(4):484.
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