A Prospective Study on Assessing the Reliability of Fine Needle Aspiration Cytology in Outcomes of Thyroid Lesions
Background: FNAC has been considered as gold standard technique to diagnose various thyroid gland lesions. As Thyroid gland is superficial in location it is easily approachable for direct physical examination, cytological evaluation & histopathological study. The main objective of FNAC of thyroid is to categorize patients who need surgery for neoplastic disorder from those having functional or inflammatory abnormality requiring a clinical follow up & medical treatment. Aims & Objectives: To study cytomorphological features of thyroid enlargement & palpable lesions of thyroid. To correlate cytomorphological features of thyroid lesions with histopathological features wherever possible. Methods: The present study was conducted in Department of Clinical Pathology, Lok Nayak Jai Prakash Narayan Hospital. Around 150 cases of thyroid lesions were enrolled during the period 3 years (March 2014-February 2017). All relevant clinical profile of these cases was taken from case records. Results: In the present study, a total of 150 cases of thyroid swellings were categorized under TBSRTC. Of which maximum cases were seen of benign etiology i.e. colloid goitre more commonly affecting middle age group i.e. 31-45yrs with female preponderance. As sensitivity & specificity of FNAC was considered, in benign Sensitivity & specificity was reported to be 96% & 100% respectively. Whereas, in malignant lesions both were found to be 100%. Conclusions: The conclusion drawn from this study implicates FNAC as a useful primary investigative modality for evaluation of palpable thyroid lesions. It also helps in distinguishing lesions based on the clinical management required.
2. Tunbridge WM: The spectrum of thyroid disease in a community. The Wicham Survey. Clin Endocrino. 1997;17:481-493.
3. Clark DP, Faquin WC. Thyroid Cytopathology. 2nd ed. New York: Springer; 2010.
4. Manoj G, Savita G, Vedbhushan G. Correlation of fine needle aspiration cytology with histopathology in the diagnosis of solitary thyroid nodule. J Thyroid Res. 2010;10:1-5.
5. Shirish C, Neha S, Harsh K, Pagaro P, Charusheela G, Mohit R. Clinicopathological correlation of thyroid nodules.. Int J Pharm Biomed sci. 2012; 3(3):97-102.
6. Gita J, Orell SR. Thyroid. In: Orell SR, Sterrett GF, editors. Fine Needle Aspiration Cytology. 5th ed. Philadelphia: Churchill Livingstone; 2012.118-55.
7. Sanchez MA, Stahl RE. The Thyroid, Parathyroid, & Neck Masses other than lymph nodes. In: Koss LG, Malamed MR, editors. Koss Diagnostic cytology & its histopathological bases. 5th ed. Philadelphia. Lipincott Williams & Wilkins; 2006.1149-86.
8. Bibbo M. Comprehensive Cytopathology. 2nd ed. Philadelphia, PA: W.B. Saunders Company; 1997. p. 673.
9. Jo VY, Stelow EB, Dustin SM, Hanley KZ. Malignancy risk for fine‑needle aspiration of thyroid lesions according to the Bethesda System for Reporting Thyroid Cytopathology. Am J Clin Pathol. 2010;134:450‑6
10. Bommanahalli BP, Bhat RV, Rupanarayan R. A cell pattern approach to interpretation of fine needle aspiration cytology of thyroid lesions: A cyto‑histomorphological study. J Cytol.2010;27:127‑32.
11. Rangaswamy M, Narendra K, Patel S, Gururajprasad C, Manjunath G. Insight to neoplastic thyroid lesions by fine needle aspiration cytology. J Cytol. 2013;30:23‑6.
12. Gupta M, Gupta S, Gupta VB. Correlation of fine needle aspiration cytology with histopathology in the diagnosis of solitary thyroid nodule. J Thyroid Res. 2010; 2010:379051.
13. Yassa L, Cibas ES, Benson CB, Frates MC, Doubilet PM, Gawande AA, et al. Long‑term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation. Cancer. 2007; 111:508‑16.
14. Silverman JF, West RL, Larkin EW, Park HK, Finley JL, Swanson MS, et al. The role of fine‑needle aspiration biopsy in the rapid diagnosis and management of thyroid neoplasm. Cancer. 1986; 57:1164‑70.
15. Handa U, Garg S, Mohan H, Nagarkar N. Role of fine needle aspiration cytology in diagnosis and management of thyroid lesions: A study of 434 patients. J Cytol. 2008;25:13‑7
16. Swamy GG, Madhuravani S, Swamy GM. Fine needle aspiration cytology – A reliable diagnostic tool in the diagnosis of thyroid gland enlargements. Nepal Med Coll J. 2011;13:289‑92.
17. Singh DK, Kumar R, Paricharak SD, Nigam N, Nigam SK. Role of fine needle aspiration cytology in solitary thyroid nodules. J Evol Med Dent Sci. 2013;36:6903‑14.