Neuropathy in cases of Hypothyroidism as Confirmed by Motor Nerve Conduction Studies: A Prospective Study in a Tertiary Care Hospital

Neuropathy in cases of Hypothyroidism

  • Manoj Kumar Jain Assistant Professor, Dept. of General Medicine, Saraswathi Institute of Medical Sciences, Hapur.
  • Gunjan Jain Assistant Professor, Dept. of Physiology, G.S. Medical College, Hapur.
Keywords: Hypothyroidism, Nerve Conduction Study, Neuropathy

Abstract

Background: Thyroid hormone play important role in development of Central Nervous System and in myelination of neurons. Patients of hypothyroidism may suffer from peripheral nervous dysfunction. Aim of our study is to find out the neuropathy in hypothyroidism. Methods: This prospective study was conducted on 40 subjects, out of which n=20 were euthyroid control and n=20 were hypothyroid. The Study was performed in the Medicine department of Saraswathi Institute of Medical Sciences, Hapur in collaboration with the department of Physiology at G.S. Medical College, Hapur. MNCV and latency of Median, Ulnar, and Common Peroneal nerve of both upper and lower limb were done in patients of Hypothyroidism and in Control subjects. Results: Significant bilateral decrease is observed in the MNCV of the Median Nerve in Hypothyroid subjects as compared to the control subjects. Also, there  is Significant  bilateral  increase  in the  Motor Latency of the Median Nerve in Hypothyroid subjects as compared to the control subjects. Conclusion: Hypothyroidism cause significant decrease in MNCV of Median Nerve as well as increase in Motor latency in Median Nerve.

Downloads

Download data is not yet available.

References

1. Bernal J. Iodine and brain development (1999). Biofactors 10:271–276.
2. Oppenheimer JH and Schwartz HL (1997). Molecular basis of thyroid hormone dependent brain development. Endocr Rev 18: 462–475.
3. Oppenheimer JH, Schwartz HL, Mariash CN, Kinlaw WB, Wong NCW, and Freake HC (1987). Advances in our understanding of thyroid hormone action at the cellular level. Endocr Rev 8: 288–308.
4. Amato A.A.: Endocrin Myopathies and Toxic Myopathies. Ed: Brown William F., Bolton Charles F., Aminof Michael J,2002.: Neuromuscular Function and Disease. Basic, Clinical and Electrodiagnostic Aspects, Vol. 2, 78:1399-1402, W.B. Saunders Company, Philadelphia.
5. Latov N. Peripheral Neuropathies. Ed: Rowland L,P, 1995. Merritt’s textbook of neurology. Williams & Wilkins,649-676.
6. Palumbo C.F., Szabo R.M., Olmsted S.L., Sacramento C.A, 2000.: The effect of hypothyroidism and thyroid replacement on the development of carpal tunnel sydrome. J Hand Surgery., 25(4):734-739.
7. Dumitru D, Amato AA. Acquired neuropathies In: Dumitru D, Amato AA, Zwarts MJ, eds. Electrodiagnostic medicine. 2nd ed. Philadelphia, PA: Hanley & Belfus Inc; 2002b:947e948,984.
8. Mishra UK, Kalita J (2006). Clinical neurophysiology.2nd ed.New Delhi:Elsevier .p.21-46
9. Somay G, Oflazo glu B, Us O, Surardamar A. Neuromuscular status of thyroid diseases,(2007): a prospective clinical and electrodiagnostic study. Electromyogr Clin Neurophysiol;47:67e78.
10. Yüksel, G., Karlikaya, G., Tanridağ, T., Us, Ö., & Akyüz, G. (2007). Journal of Neurological Sciences [ Turkish ] 24 :( 1 )10 ; 7-15 , 2007 Nerve Conduction Studies , SEP and Blink Reflex Studies in Recently Diagnosed , Untreated Thyroid Disease Patients.
11. Nemni R, Bottacchi E, Fazio R, et al (1987). Polyneuropathy in hypothyroidism: clinical, electrophysiological and morphological findings in four cases. J Neurol Neurosurg Psychiatry ; 50:1454–60.
12. Cruz, M. W., Tendrich, M., Vaisman, M., & Novis, S. a. (1996). Electroneuromyography and neuromuscular findings in 16 primary hypothyroidism patients. Arquivos de neuropsiquiatria, 54(1), 12–8.
13. El-Salem, K., & Ammari, F. (2006). Neurophysiological changes in neurologically asymptomatic hypothyroid patients: a prospective cohort study. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 23(6), 568–72.
Published
2017-09-23
How to Cite
1.
Jain M, Jain G. Neuropathy in cases of Hypothyroidism as Confirmed by Motor Nerve Conduction Studies: A Prospective Study in a Tertiary Care Hospital. IABCR [Internet]. 23Sep.2017 [cited 21Jul.2019];3(3):19-1. Available from: https://iabcr.org/index.php/iabcr/article/view/46