HAIR-AN Syndrome: Inside Story

  • K R Sharma Pacific Medical College and Hospital, Udaipur, India
  • Abhishek Laddha
  • B S Bomb
  • S Verma
  • H Sharma
Keywords: HAIR-AN syndrome, acanthosis nigricans, hirsutism, hyperandrogenism, insulin resistance.

Abstract

15-year-old adolescent girl presented with weight gain, irregular menstrual cycle, skin lesions suggestive of acanthosis nigricans and hirsutism. On evaluation, she was found to have elevated testosterone levels with normal FSH, LH and fasting blood sugar, decreased glucose insulin index suggestive of Insulin resistance. In view of above features, diagnosis of hyperandrogenism-insulin resistance-acanthosis nigricans syndrome (HAIR-AN syndrome) was made. This syndrome is considered as a sub-type of polycystic ovary syndrome (PCOS). HAIR-AN syndrome has varied presentation and is usually seen by primary care physician, gynaecologist or dermatologist. Life style modification with weight reduction and drugs such as metformin helps in alleviating the symptoms. With limited resources in our country, diagnosis is frequently delayed leading to systemic complications. Early diagnosis and appropriate treatment would help in preventing complications of obesity, insulin resistance leading to coronary artery disease, Type 2 diabetes mellitus, hyperlipidemia. Depression and suicidal behavior may be associated with it and should be aggressively addressed in young adults suffering from HAIR-AN syndrome.

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Author Biographies

K R Sharma, Pacific Medical College and Hospital, Udaipur, India

Professor, Department of Medicine

Abhishek Laddha

Assistant Professor, Department of Surgery, section Urology and IVF, Pacific medical college, Udaipur , India.

B S Bomb

Professor, Department of Medicine, Pacific Medical College and Hospital, Udaipur, India

S Verma

Medical Officer, RNT Medical College, Udaipur, India. 

H Sharma

Clinical Embryologist, SMS Medical College, Jaipur, India.

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Published
2017-09-23
How to Cite
1.
Sharma KR, Laddha A, Bomb BS, Verma S, Sharma H. HAIR-AN Syndrome: Inside Story. Int Arch BioMed Clin Res [Internet]. 2017Sep.23 [cited 2019Nov.19];3(3):3-. Available from: https://iabcr.org/index.php/iabcr/article/view/42