The Prospective Study on Acute Leukemia in Tertiary Care Teaching Hospital in Rajsamand
Background: Acute leukemia are characterized by clonal expansion of immature myeloid or lymphoid precursors (blasts). The blasts cells are known to replace the normal hematopoietic tissues and to invade other organs of the body as well. Anemia, hemorrhage and infections occurring due to bone marrow failure are the top three complications of acute leukemia.
Methods: This study was carried out in the Department of Pathology, Ananta Institute of Medical Sciences and Research Centre, Rajsamand
Results: In The present study, 32 cases of different patterns of acute leukemia were reported. According to hematological parameters, 25 cases (78.1%), 2 cases (6.25%), 3 cases (28.1%) and 2 cases (6.25%) were reported as acute leukemia, AML, ALL and bi-lineage leukemia respectively.
Conclusions: The present study showed that AML is more prevalent than ALL. It is observed that ALL is more common in children. The incidence of AML is higher in adults in comparison to children and decreases towards older age.
2. 4th Ed. Philadelphia: Saunders; 1987: p. 351-406.
3. Childs c.c; and Stass SA. Introduction, Characterization & Diagnosis of acute leukemia. In the Acute Leukemia. (ed by) Stass SA. New York and Basel. Marcel Dekker Inc; 1987: p.1-26
4. Bonnet D, John ED. Human AML is organized as a hierarchy that originates from a primitive haematopioetic cell. Nature Medicine Vol. 3 July 1997. p.730-37.
5. Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC, 2001.
6. Luke KH. Paediatric oncology – current clinical practice. Medicine N. Am 1989;30:5569- 5579.
7. Neglia JP, Robison LL. Epidemiology of the childhood acute Leukemia: Prediartic Clinics No. Am 1988;35:676- 92.
8. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the clinical advisory committee meeting-Airlie house, Virginia, November 1997. J Clin Oncol 1999;17:3835-49.
9. Gupta A, Pal A, Nelson SS. Immunophenotyping in Acute Leukemia: A Clinical Study. International Journal of Scientific Study; August 2015, Vol 3, Issue 5, p.130
10. Poplack DC; and Reaman G: Acute Lymphoblastic Leukemia in childhood. Prediartic clinics N. Am 1988; 35: 903-32.
11. Noor NA, Masood M. Clinico-epidemiological study of Leukemia in Multan: Pak J Med Research 1989; 28: 232-43.
12. Khalidi HS, Medeiros LJ, Chang KL, Brynes RK, Slovak ML, Arber DA. e immunophenotype of adult acute myeloid leukemia: High frequency of lymphoid antigen expression and comparison of immunophenotype, French-American-British classification, and karyotypic abnormalities. Am J Clin Pathol 1998;109:211-20.
13. Ghosh S, Shinde SC, Kumaran GS, Sapre RS, Dhond SR, Badrinath Y, et al. Haematologic and immunophenotypic profile of acute myeloid leukemia: An experience of Tata memorial hospital. Indian J Cancer 2003;40:71-6.
14. Shanta V, Maitreyan V, Sagar TG, Gajalakshmi CK, Rajalekshmy KR. Prognostic variables and survival in pediatric acute lymphoblastic leukemias: Cancer institute experience. Pediatr Hematol Oncol 1996;13:205-16.
15. Magrath I, Shanta V, Advani S, Adde M, Arya LS, Banavali S, et al. Treatment of acute lymphoblastic leukaemia in countries with limited resources; lessons from use of a single protocol in India over a twenty year period. Eur J Cancer 2005;41:1570-83.
16. Annual report. (1086-1987) Classification and diagnosis of leukemias.