Prevalence of Rheumatoid Arthritis patients in Adults: A Hospital Based Study
Background: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by a symmetrical inflammation of the synovium, resulting in tenderness and destruction of bone and cartilage in various joints, particularly the smaller joints of the hands and feet. Although the cause of RA is unknown, autoimmunity plays a pivotal role in its chronicity and progression. RA affects approximately 1.0% of the general population, women more often than men, and the inflammatory burden of the disease results in functional disability. Methods: Forty patients were included in this study. The case control study was carried out in the Department of Orthopaedics, Geetanjali Medical college and Hospital, Udaipur. Duration of this study was six month. Results: In the present study, forty patients were included, out of which 15% male and 85% female. From the forty patients most of the people were belongs to 41-50 age group followed by 51-60 (27.5%) ,35-40 (25%) ,61-65(17.5%). Elevated ESR were in the 52.5% of group, rest of the people were normal. Same as in case of CRP positive found in the 52.5% & 47.5% were negative. Conclusion: The prevalence in RA group quite high as compared to general population.
2. Gibofsky A. 2012. Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis. The American Journal of Managed Care 18:S295_S302.
3. Begovich Ab et. al. 2004. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. American Journal of Human Genetics 75:330_337 DOI 10.1086/422827.
4. Barton A, Worthington J. 2009. Genetic susceptibility to rheumatoid arthritis: an emerging picture. Arthritis and Rheumatism 61:1441_1446 DOI 10.1002/art.24672.
5. Lindhardsen J, Ahlehoff O, Gislason GH, Madsen OR, Olesen JB, Svendsen JH, Torp- Pedersen C, Hansen PR. 2012. Risk of atrial fibrillation and stroke in rheumatoid arthritis: danish nationwide cohort study. BMJ 344:e1257 DOI 10.1136/bmj.e1257.
6. Aletaha Det. Al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collab-orative initiative. Arthritis and Rheumatism 62:2569_2581 DOI 10.1002/art.27584.
7. Felson DT, et. Al 2011. American College of Rheumatology/European League against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials. Annals of the Rheumatic Diseases 70:404_413
8. Stockbridge, H., Hardy, R. I., & Glueck, C. J. (1989). Public cholesterol screening: Motivation for participation, follow-up outcome, self-knowledge and coronary heart disease risk factor intervention. J Lab Clin Med, 114, 142-151
Fossati, P., & Prencipe, L. (1982). Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clinical Chemistry, 28, 2077-80.
Lopes-virella, M. F., Stone, P., Ellis, S., & Colwell, J. A. (1977). Cholesterol determination in high-density lipoproteins separated by three different methods. Chemical Communications, 23, 882–3.
11. Karvounaris SA, Sidiropoulos PI, Papadakis JA, Spanakis EK,
Bertsias GK, Kritikos HD, et al. Metabolic syndrome is common among middle-to-older aged Mediterranean patients with rheumatoid arthritis and correlates witdisease activity: a retrospective, cross-sectional, controlled, study. Ann Rheum Dis. 2007;66:28–33.
12. La Montagna G, Cacciapuoti F, Buono R, Manzella D, Mennillo GA, Arciello A, et al. Insulin resistance is an independent risk factor for atherosclerosis in rheumatoid arthritis. Diabetes Vasc Dis Res. 2007;4:130–5.
13. Chung CP, Oeser A, Solus JF, Avalos I, Gebretsadik T, Shintani A, et al. Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis. Atherosclerosis. 2008;196:756–63.
14. Stevens RJ, Douglas KM, Saratzis AN, Kitas GD. Inflammation and atherosclerosis in rheumatoid arthritis. Expert Rev Mol Med. 2005;7:1-24
Copyright (c) 2017 International Archives of BioMedical and Clinical Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.