Placental Site Trophoblastic Tumour – A Rare Cause of Uncontrollable Post- Operative Hemorrhage in Obstetric
DOI:
https://doi.org/10.21276/bjdeey41Keywords:
Post- Operative Hemorrhage, Trophoblastic TumourAbstract
Placental site trophoblastic tumour (PSTT) is a rare variant of gestational trophoblastic disease developing from intermediate trophoblasts. PSTTs are incredibly rare tumours with 1 in 100000 pregnancies and only about 200 cases reported till date with mortality reaching up to 25% in undiagnosed cases. We present the case of a 37year old female, gravida 4 para 3, presenting with uncontrollable post caesarean haemorrhage for which she underwent subtotal hysterectomy. Histopathological examination revealed Placental site trophoblastic tumour. Placental site trophoblastic tumour, being a rare entity, pose difficulties in its early diagnosis. Delayed diagnosis can lead to distant metastases, thus worsening the prognosis.
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References
Kurman RJ, Scully RE, Norris HJ. Trophoblastic pseudotumor of the uterus: an
exaggerated form of "syncytial endometritis" simulating a malignant tumor.
Cancer. 1976;38(3):1214-26.
Scully RE & Young RH. Trophoblastic pseudotumor: a reappraisal. Am J Surg
Pathol. 1981;5(1):75-6.
Zeng X, Liu X, Tian Q, Xue Y, An R. Placental site trophoblastic tumor: A case
report and literature review. Intractable Rare Dis Res. 2015;4(3):147-151.
Bouquet de la Jolinière J, Khomsi F, Fadhlaoui A, Ben Ali N, Dubuisson JB, Feki
A. Placental site trophoblastic tumor: a case report and review of the literature.
Front Surg. 2014;1:31.
Kaur B. Pathology of gestational trophoblastic disease (GTD). Best Pract Res
Clin Obstet Gynaecol. 2021;74:3-28.
Valzacchi GM, Odetto D, Chacon CB, Wernicke A, Xiang Y. Placental site
trophoblastic disease. Int J Gynecol Cancer. 2020;30(1):144-9.
Hui P, Wang HL, Chu P, Yang B, Huang J, Baergen RN, et al. Absence of Y
chromosome in human placental site trophoblastic tumor. Mod Pathol.
;20(10):1055-60.
Hui P, Parkash V, Perkins AS, Carcangiu ML. Pathogenesis of placental site
trophoblastic tumor may require the presence of a paternally derived X
chromosome. Lab Invest. 2000;80(6):965-72.
Lee HJ, Shin W, Jang YJ, Choi CH, Lee JW, Bae DS, et al. Clinical
characteristics and outcomes of placental site trophoblastic tumor: experience of
single institution in Korea. Obstet Gynecol Sci. 2018;61(3):319-27
Young, R., Scully, R., Mccluskey, R.A. Distinctive Glomerular Lesion
Complicating Placental Site Trophoblastic Tumour: Report of Two Cases.
Hum.Pathol. 1985;16:35-42.
Lan C, Li Y, He J, Liu J. Placental site trophoblastic tumor: lymphatic spread and
possible target markers. Gynecol Oncol.2010;116:430–7.
Shih IM & Kurman RJ. p63 expression is useful in the distinction of epithelioid
trophoblastic and placental site trophoblastic tumors by profiling trophoblastic
subpopulations. Am J Surg Pathol. 2004;28(9):1177-83.
Shih IM & Kurman RJ. Ki-67 labeling index in the differential diagnosis of
exaggerated placental site, placental site trophoblastic tumor, and
choriocarcinoma: a double immunohistochemical staining technique using Ki-67
and Mel-CAM antibodies. Hum Pathol. 1998;29(1):27-33.
Shih IM & Kurman RJ. Epithelioid trophoblastic tumor: a neoplasm distinct from
choriocarcinoma and placental site trophoblastic tumor simulating carcinoma.
Am J Surg Pathol. 1998;22(11):1393-403.
Gari, A. Placental site trophoblastic tumor and choriocarcinoma: an unusual
presentation. BMC Res Notes. 2015;8(1):1-4.
Alexander AL, Strohl AE, Maniar KP, Lurain JR. Placental site trophoblastic
tumor: successful treatment of 13 cases. Gynecol Oncol Rep. 2020;32:100548.
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