Prevalence of Dyslipidaemia in Type 2 Diabetes Mellitus: A Prospective Study in a Tertiary Care Hospital
Background: Atherosclerosis leading to ischemic heart disease remains the major cause of death and premature disability in developed countries and its prevalence is rising constantly in developing countries. Dyslipidaemia due to insulin resistance, the major cause of coronary atherosclerosis and ischemic heart disease is frequently associated with type 2 diabetes mellitus. Type 2 diabetes mellitus is an emerging pandemic with the number of patients increasing rapidly in both developed and developing countries around the world.
Materials & Methods: In this study lipid abnormalities associated with type 2 diabetes mellitus were studied and association between HbA1C level and extent of dyslipidaemia detected. In this cross- sectional study 60 known cases of type 2 diabetes mellitus will be selected. They will be investigated for HbA1C and lipid profile.
Results: In the present study, dyslipidaemia was found to be present in 88% patients of type 2 diabetes mellitus. Of these, 22% had single abnormal lipid parameter while 66% had combined dyslipidaemia. There was significant correlation between HbA1C & total cholesterol, HbA1C & LDL cholesterol, HbA1C & triglycerides, HbA1C & Tc/HDL ratio and HbA1C & non HDL cholesterol.
Conclusion: Prevalence of dyslipidaemia was alarmingly high in type 2 diabetes mellitus patients. Thus, HbA1C can be considered as a marker of dyslipidaemia in type 2 diabetes mellitus.
2. Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA et al. Association of glycemia with macrovascular and microvascular complications of type 2 diabetes: prospective observational study. British Medical Journal 2000;321:405-412
3. Turner RC, Millns H, Neil NA, Stratton IM, Manley SE, Matthews DR et al. Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study. British Medical Journal 1998;316:823-828
4. Ramaiya KL, Kodali VR, Alberti K. Epidemiology of diabetes in Asians of the Indian subcontinent. Diabetes Metabolism Review. 1990;6:125-146
5. Ramachandran A, Snehlatha C, Dharmaraj D, Viswanathan M. Prevalence of glucose intolerance in Asian Indians: Urban Rural difference and significant upper body adiposity. Diabetes Care 1992; 15: 1348-1355
6. American Diabetes Association. Diagnosis and classification of Diabetes mellitus. Diabetes Care. 2010;33:s62-s69
7. National Cholesterol Education Programme (NCEP) Adult Treatment Panel III (A TP III) guideline. http://www.nhlbi.nih.gov/guidelines/cholesterol/index.htm as
visited on 19/9/13
8. Mahato RV, Gyawali P, Raut PP, Regmi P, Singh KP, Pandeya DR et al. Association between glycaemic control and serum lipid profile in type 2 diabetic patients: Glycated haemoglobin as a dual biomarker. Biomed Res. 2011;22(3):375-80.
9. Jisieike-Onuigbo NN, Unuigbe EI, Oguejiofor CO. Dyslipidemia in type 2 diabetes mellitus in Nnewi south-east Nigeria. Annals of African Medicine 2011;11(1): 25-31
10. Okafor CI, Fassanmade OA, Oke DA. Pattern of dyslipidaemia among Nigerians with type 2 diabetes mellitus. Nigerian Journal of Clinical Medicine. 2008; 11(1): 25-31.
11. Singh G, Kumar A. Relationship among HbA1C and Lipid profile in Punjabi Type 2 diabetic population. J Exer Sci Physiotherapy. 2011;7(2):99-102
12. Sreenivas RA, Meera S, Ebenezer W, Kumar JS. Correlation between glycemic control and lipid profile in type 2 diabetic patients: HbA1C an indirect indicator of dyslipidaemia. Asian J Pharma Clin Res. 2014;7(2):153-155
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