Vitamin D Estimation: A New Biomarker for Cardiovascular Disease
Background: Vitamin D deficiency is prevalent in the majority parts of the world. The prevalence of vitamin D deficiency in India in urban area 9-11% and in rural area 3-6%. Coronary artery disease is worldwide health problem and consists of variety of heart illness. Vitamin D deficiency may cause cardiovascular events by a variety of potential biological mechanism.
Aims & Objectives: To evaluate the role of vitamin D as a rising risk factor for coronary artery disease. Materials & Methods: The study was carried out in department of Cardiology, S.P. Medical College included 50 patients of coronary artery disease admitted in H.R.M. Center Bikaner. The control population comprise of age and sex matched 50 healthy persons. Vitamin D was done on ELISA reader and lipid profile assessment was done on fully automated analyzer. The statistical analysis was done by using SPSS software. The results were articulated as Mean ± SD. The Student t-test was carried out for relationship of the data & P value <0.05 was considered statistically significant.
Results: The study discovered that vitamin D level was established to be significantly lower in cases as compared to controls. We also noticed significant difference in mean to total cholesterol, HDL cholesterol and LDL cholesterol in between cases and control.
Conclusion: This study concluded that continue follow up of vitamin D will be helpful for measurement of increased risk of coronary artery disease episode beyond the traditional risk factors.
2. A.K. Pancholia et al Vitamin D deficiency: An emerging risk factor for cardiovascular J. Preventive Cardiology - Vol. 1 - No. 4 - May 2012 153.
3. Ramesh Aggarwal,1 Tauseef Akhthar, and Sachin Kumar Jain Coronary artery disease and its association with Vitamin D deficiency J Midlife Health. 2016 Apr-Jun; 7(2): 56–60.
4. Nibbelink KA, Tishkoff DX, Hershey SD, Rahman A, Simpson RU. 1,25(OH)2-vitamin D3 actions on cell proliferation, size, gene expression, and receptor localization, in the HL-1 cardiac myocyte. J Steroid Biochem Mol Biol Mar. 2007;103:533–7.
5. Wu-Wong JR, Nakane M, Ma J, Ruan X, Kroeger PE. Effects of Vitamin D analogs on gene expression profiling in human coronary artery smooth muscle cells. Atherosclerosis. 2006;186:20–8. [PubMed]
6. Merke J, Milde P, Lewicka S, Hügel U, Klaus G, Mangelsdorf DJ, et al. Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermalcapillaries. J Clin Invest.
7. Zahra Dana Siadat, Keyvan Kiani,1 Masoumeh Sadeghi,2 Amir Sina Shariat,1 Ziba Farajzadegan, and Maryam Kheirmand Association of vitamin D deficiency and coronary artery disease with cardiovascular risk factors J Res Med Sci. 2012 Nov; 17(11): 1052–1055.
8. Cora McGreevy and David Williams New Insights About Vitamin D and Cardiovascular Disease Ann Intern Med. 2011;155:820-826.
9. Sanjeev Kumar Syal et al Vitamin D Deficiency, Coronary Artery Disease, and Endothelial Dysfunction: Observations From a Coronary Angiographic Study in Indian Patients Volume 24 - Issue 8 - August 2012 (/issue/3452). Pittas AG, Harris SS, Stark PC, et al. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes care 2007 30(4) 980-986.
10. Saneei P, Salehi-Abargouei A, Esmaillzadeh A. Serum 25-hydroxy vitamin D levels in relation to body mass index: a systematic review and meta-analysis. Obes Rev 2013;14(5):393–404.
11. Chitalia N, Recio-Mayoral A, Kaski JC, et al. Vitamin D deficiency and endothelial dysfunction in non-dialysis chronic kidney disease patients. Atherosclerosis 2012 220(1) 265-268.
12. Judd S, Tangpricha V. Vitamin D deficiency and risk for cardiovascular disase. Circulation. 2008;117:503– 11.
13. Zittermann A, Schleithoff SS, Koefer R. Putting cardiovascular disease and vitamin D insufficiency into perspective. Br J Nutr 2005; 94 : 483-92.
14. Watson KE, Abroiat ML, Malone LL, Hoed JM, Doheerty T, Detrano R, et al. Active vitamin D levels are inversely correlated with coronary calcification. Circulation 1997; 96 :1755-60.
15. Mahdavi K, Amirajam Z, Yazdankhah S, et al. The prevalence and prognostic role of vitamin D deficiency in patients with acute coronary syndrome: a single centre study in South-West of Iran. Heart Lung Circ 2013 ;22(5):346-51.
16. Lindqvist PG, Epstein E, Olsson H. Does an activesun exposure habit lower the risk of venous thrombotic events? A D-lightful hypothesis. J Thromb Haemost. 2009; 7: 605 – 610.
17. Giovannucci E. 25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men A Prospective Study. Arch Intern Med 2008; 168(11): 1174-80.
18. Sun Q, Pan A, Hu FB, Manson JE, Rexrode KM. 69. 25-hydroxyvitamin D levels and the risk of stroke: a prospective study and meta-analysis. Stroke 2012; 43 :1470-7.
19. Chowdhury R, Stevens S, Ward H, Chowdhury S, Sajjad 70. A, Franco OH. Circulating vitamin D, calcium and risk of cerebrovascular disease: a systematic review and meta-analysis. Eur J Epidemiol 2012; 27 : 581-91.
20. A.K.Pancholia MD, Vidyut Jain MD, Vijay Garg MD, Vitamin D deficiency : An emerging risk factor for cardiovascular disease Journal of preventive cardiology 2012 volume 1 issue:4; 153-163.
21. Skaaby T, Husemoen LLN, Pisinger C, Jørgensen T, Thuesen BH, Fenger M, et al., Vitamin D status and changes in cardiovascular risk factors: A prospective study of a general population, Cardiology 2012; 123:62–70.
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