Efficacy of Dolichos - Biflorus in Urinary Calculus Disease: A Clinical & Biochemical Study
Background: Urolithiasis is a disease as old as civilization and this has been troubling mankind from the very beginning of history. Seeds as well as extract of D. biflorus have frequently been used by patients of urolithiasis for dissolution of urinary calculi or to prevent recurrence. The present project has been undertaken to evaluate its effect on urine chemistry of stone formers.
Materials & Methods: Twenty two patients suffering from radiologically proved urinary calculus disease treated at district Hospital, Dungarpur were included in the present study. A detailed history in respect to family history of calculus disease, socio-economic status, dietary habits, present and past complaints some clinical findings were recorded. The clinical trial of Dolichos biflorus was carried out in postoperative period of operated patients.
Results: The age ranged from 9 to 70 years and men was 35.45 (+15) years. The body surface area ranged from 0.63 to 1.60m2 and mean was 1.53 (+0.25) m2. The lowest 24 hours volume in the 1st sample (pre-operative) was 320 ml. and highest was 2300 ml., mean being 2000 ml. in volume. In IInd samples (post-operative) the 24 hours urine volume ranged from 560 to 2250 ml. mean being 1338 (+515) ml. Three urine samples measured more than 2000 ml. in volume. In IIIrd samples (post Dolichos) the urinary volume ranged from 600 to 2620 mm1/24 hours, mean being 1494 (+ 565) ml. and four urine samples measured more than 2000 ml.
Conclusion: We concluded that our study does not show any protective action of Dolichos biflorus ingestion on urolithiasis.
2. Pendse A.K., Ghoshs R., Goyal A and Singh P.P. Effect of indigenous drugs on idiopathic hyperoxalluria in stone former. Asian Med J. Feb. 1984;27 (2).
3. Singh P.P., Pendse A.K., Goyal alka, Ghoshs, Rita srivastava A.K. and kumawat J.L. Blood and urine chemistry of stone formers in local population and evaluation of cystone. 1983.
4. Pak, C.Y.C.; Cox, J.W ; Powell, E. and Bartler, T.C. Effect of the oral administration of Ammonium Chloride, Sodium Phosphate, cellulose phosphate and parathyroid extract on the activity product of brushite in urine. Am. J. Med. 1978;50 : 67.
5. Pyrah, L.N.: Renal Calculus. Springer- Verlog, Heidelberg New York, 1979.
6. Nath et al; Role of magnesium in idiopathic urolithiasis. 1984; 7: 104.
7. Thind S.K. and Nath R. Chemical analysis of urinary calculi in Chandigarh area. Ind. J. Med. Res. 1969;57:1790.
8. Modlin M. Renal stone and sodium. Lancet I 1967:1162.
9. Singh: Sodium neither a risk nor a protective factor in urolithiasis. Urol. Res. 1986.
10. Singla, S.K. and Kanwar, K. In of calcification from Dolichos biflorus, urological Research.1984; 12 : 88.
11. . King, E.J. and Wotton, I.D.P. : Microanalysis in Medical Biochemistry III Ed. J. and A. Churchill Ltd., London, 1956.
12. Natelson : Techniques of clinical chemistry III Ed., Charls, C. Thomas, U.S.A. 1971.
13. Hodgkinson, A. : Oxalates in biology and Medicine. Academic Press London , 1979.
14. Banerjee and S.K. Roy : Reaction of struvite with naturally occuring polyphosphates and hydroxy acids. III NCUSI, Udaipur, 1985.
15. Robertson, .G.; Peacock, M.E.; Nordin, B.E.C. : Calcium oxalate crystalluria and urine saturation in recurrent stone formers. Clin. Sci.1971; 40: 365.
16. Menon, M.,Mahler C.J. t Oxalate metabolism and renal calculi. J. Urol. 1982; 127 : 148.