Influences of Total Life Style Changes in Leptin Level in Obese Type 2 Diabetes Mellitus

  • Narendra Solanki Junior Specialist (MD, Internal Medicine), Sattellite Hospital Mandore, Jodhpur, Rajasthan, India.
  • Dilip Singh Rathore Junior Specialist (MD, Internal Medicine), Bangur Hospital, Pali, Rajasthan, India.
Keywords: Leptin, Obesity, Diabetes mellitus, Total lifestyle changes (TLC) intervention.


Background: To investigate the change of leptin levels after a total life style changes  (diet, exercise induced weight loss and behaviors modification) and the possible association between leptin and total life style changes (TLC) in obese subjects.

Materials & Methods: A total number of forty obese subjects (twenty patients of DM type 2 and twenty age and sex matched healthy obese controls) divided into two different group (twenty in each) were studied. After recording a detailed history, a complete physical examination was carried out. Fasting serum leptin levels estimated and both group total life style changes intervention (diet control and exercise induced weight loss and behaviors modification) was given and after duration of eight-week TLC intervention, all subjects were reexamined and fasting serum leptin levels were re-estimated.

Results: Obese diabetic group shows significant reduction in leptin levels 3.15 ± 10.87 in comparison with obese nondiabetic group 1.77 ± 9.21.

Conclusion: Total lifestyle changes intervention (diet control and exercise induced weight loss and behaviors modification) significantly reduces leptin levels and significantly reduces the anthropometrics values and biochemical values in obese type 2 diabetes mellitus in comparison with obese nondiabetic group. 


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1. World Health Organization. Available at: http:/ November 2004.
2. Coleman, DL (1973) Effects of parabioses of obese with diabetes and normal mice. Diabetiologia 9, 294-298,1973.
3. Kennedy GC, The role of depot fat in the hypothalamic control of food intake in the rat procRSOC, Lond B Biol Sci 1953;140:578-596.
4. Zhang, Y, Proenca, R, Maffaei, M, Barone.M, Leopold,L, Friedman,JM(1994) Positional cloning of mouse obese gene and its human homologue Nature 372,425-432.
5. Maffei M, Fei H, Lee G-H, et al 1995 Increased expression in adipocytes of ob RNA in mice with lesion of the hypothalamus and with mutation at the db locus proc Natl Acad Sci, USA 92: 6957-6960.
6. Halas JL, Gajiwala KS, Maffei M, et al 1995 weight reducing effect of the plasma protein encoded by the obese gene Science 269: 543-546.
7. Pelley mounter NA, Cullen MJ, Baker MB, et al 1995 effect of the obese gene product on body weight regulation in ob/ob mice Science 269-540-543.
8. Lee, GH, Proenca, R, Montez,Jm, et al(1996) Abnormal splicing of the leptin receptor in diabetic mice Nature 379,632-635.
9. Montague, CT, Farooqui, IS, Whitehead, JP, et al (1997) Congenital leptin deficiency is associated with severe early onset obesity in human. Nature 387,903-908 1997.
10. Clement, K, Vaisse, C,Lahlov,N, et al(1998) A mutation in the human leptin receptors gene causes obesity and pitutiry dysfunction. Nature 392,398-401,1998.
11. Considine, RV,Sinha, MK, Heiman,ML et al Serum immuno reactive leptin concentration in normal weight and obese humans. N.Engl J. Med 334,292-295.
12. Havel,PJ, Kasim-Karakas,S,Muller,W,Johnson,PR,Gingerrich,RL,Sterns,JS(1996) Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women; effects of dietary fat content and sustained weight loss . J. Clin Endocrinal Metab 81,4406-13.
13. Schawartz,MW, Perskind, E,Raskind, M, Boyko, EJ,Porter,D, (1996) Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in human Nature Med 2,589-593.
14. Maffei M, Halaas J, Rauussin E, et al 1995 Leptin level in human and rodent: measurement of plasma leptin an ob RNA in obese and weight reduced subjects Nut Med 1: 1155-1161,1995.
15. Considine RV, Sinha MK, Heiman ML, et al 1996 Serum immuno reactive – leptin concentration in mormal weight and obese humans N, Engl J. Med 334: 292-295.
16. Rosenbaun M, Nicolson M, Hirsch J, et al 1996 effect of gender, body composition and menopause on plasma conc. of leptin J. Clin Endocrinal Metab 81: 3424-3427.
17. Ostlund Jr. RE, Wang JW, Klein S, Gingerich R 1996: Relation between plasma leptin conc. and body fat, gender, diet, age and metabolic covariates J. Clin Endocrinal Metab 81: 3909-3913,1996.
18. Licinio J, Mantzoros C, Negrao AB, et al: Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med 3:575-579,1997.
19. Hickey, M. S., R. V. Considine, R. G. Israel, T. L. Mahar, M. R. McCammon, G. L. Tyndall, J. A. Houmard, and J. F. Caro. Leptin is related to body fat content in male distance runners. Am. J. Physiol. 271 (Endocrinol. Metab. 34): E938-E940.
20. Hickey MS, Houmard JA, Considine RV, Tyndall GL, Midgette JB, Gavigan KE, et al. Gender-dependent effects of exercise training on serum leptin levels in humans. Am J Physiol. 1997; 272(4 Pt 1):E562-6.
21. W.J.Pasman, M.S. Wasterterp Plantenga, and W.H.M. Saris. The effects of exercise on leptin levels in obese male. J. Physical End Metab 274:1849-1898,1998
22. Kohrt, W. M., M. Landt, and S. J. Birge. Serum leptin levels are reduced in response to exercise training, but not hormone replacement therapy, in older women. J. Clin. Endocrinol. Metab. 81: 3980-3985, 1996.
23. Ryan, A. S., and D. Elahi. The effects of acute hyperglycemia and hyperinsulinemia on plasma leptin levels: its relationships with body fat, visceral adiposity, and age in women. J. Clin. Endocrinol. Metab. 81: 4433-4438, 1996.
How to Cite
Solanki N, Rathore D. Influences of Total Life Style Changes in Leptin Level in Obese Type 2 Diabetes Mellitus. International Archives of BioMedical and Clinical Research [Internet]. 21Mar.2018 [cited 26Apr.2018];4(1):186-9. Available from: