Epidemiological and Histopathological Profile of Malignant Melanoma: An Institutional Based Study
DOI:
https://doi.org/10.21276/4s2wj597Keywords:
Epidemiology, Melanoma, histopathologicalAbstract
Background: The present study was aimed to analyze the epidemiological and histopathological data of patients with malignant melanoma (MM).
Materials and Methods: The present study retrospectively analyzed the data of 85 patients who were histopathologically diagnosed with malignant melanoma (MM). Data abstracted included age, sex, anatomic site and whether it was a primary or metastatic site. Breslow thickness in millimetres, Clark level of invasion, presence of ulceration and melanoma subtype were also evaluated.
Results: The study included 85 patients in total with 44 (56.4%) male and 37 (43.6%) female. Median age of the patients was 62.50 years (range: 27 - 84 years). Of the patients, 96.4% (n=82) had cutaneous melanoma, 3% mucosal melanoma. . Ninety five percent of cutaneous melanomas were located on acral sites, most commonly the foot (87%) and the most common histopathological subtype was acral lentiginous. Eighty four percent presented with a Breslow thickness over 4 mm (median 9 mm).
Conclusion: Malignant melanoma data are also important for the optimal utilization of effective methods and healthcare resources to prevent the disease.
Downloads
References
Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffel DJ, Wolff K.
Fitzpatrick's Dermatology in General Medicine, 8th edition. McGraw-Hill
company. 2012. Bailey EC, Sober AJ, Tsao H, Mihm Jr MC, Johnson
TM. Chapter 124: Cutaneous melanoma.
Stubblefield J, Kelly B. Melanoma in non-Caucasians. Surg Clin N Am.
; 94:1115–6.
Asuquo ME, Ebughe G. Cutaneous cancers in Calabar, southern
Nigeria. Dermatol Online J. 2009;15(4):11.
Lodder JV, Simson W, Becker PJ. Malignant melanoma of the skin in
black South Africans: A 15-year experience. S Afr Med J.
;48(3):76–9
Weber AL, Nunes DH, Souza Filho JJ, Pinto CJC. Assessment of 496
pathological reports of melanoma diagnosed in the city of Florianopolis,
SC, Brazil. An Bras Dermatol. 2007;82:227-32
Ferrari Júnior NM, Muller H, Ribeiro M, Maia M, Sanches Júnior JA.
Cutaneous melanoma: descriptive epidemiological study. São Paulo
Med J. 2008;126:41-7
Bonfá R, Bonfá R, Furian RD, Bonamigo RR, Duro KM, Zelmanowicz
AM. Early diagnosis of cutaneous melanoma: an observation in
southern Brazil. An Bras Dermatol. 2011;86:215-21.
Dimatos DC, Duarte FO, Machado RS, Vieira VJ, Vasconcellos ZAA,
Bins-Ely J, et al. Melanoma cutâneo Brasil. Arq Cat Med. 2009;38(Supl.
:14-9.
Tishkoff SA, Reed FA, et al. The genetic structure and history of
Africans and African Americans. Science. 2009;324(5930):1035–44.
Chang AE, Karnell LH, Menck HR. The National Cancer Data Base
report on cutaneous and noncutaneous melanoma: a summary of
,836 cases from the past decade: the American College of Surgeons
Commission on Cancer and the American Cancer Society. Cancer.
; 83(8):1664-1678.
Özçelik S, Akyol M. Epidemiology of Melanoma. Turkderm.
;41(2):1-5
Özdemir F. Malignant Melanoma. Turkiye Klinikleri J Dermatol-Special
Topics. 2013; 6(3):24-43.
Tas F, Kurul S, Camlica H, Topuz E. Malignant melanoma in Turkey: a
single institution's experience on 475 cases. Jpn J Clin Oncol. 2006;
(12):794-9.
Karasoy A, Karsidag S, Tatlidere S, Ugurlu K, Özkaya Ö, Kuan I et al.
Our Experience For 65 Patients with Malignant Melanoma in 13 years:
a retrospective study. Turk Plast Surg. 2004; 12(3):153-7.
Simsek T, Sönmez A, Ahmet Demir A, Tayfur V, Güneren E, Eroglu L,
Yildiz L. Our Clinical Experience in 84 patients with cutaneous
malignant melanoma. Turk Plast Surg. 2011; 19(3):113-6.
Kulahci Y, Zor F, Öztürk S, Eski M, Deveci M, Isik S. Retrospective
analysis of 79 malign melanoma patients. Turk Plast Surg. 2007;
(1):15-9
Amerio P, Manzoli L, Auriemma M, Carbone A, Proietto G, Angelucci
D, Tulli A. Epidemiology and clinical and pathologic characteristics of
cutaneous malignant melanoma in Abruzzo (Italy). Int J Dermatol.
; 48(7):718-22.
van der Velden HM, van Rossum MM, Blokx WA, Boezeman JB,
Gerritsen MJ. Clinical characteristics of cutaneous melanoma and
second primary malignancies in a dutch hospital-based cohort of
cutaneous melanoma patients. Dermatol Res Pract. 2009; 479183:1-8.
Nagore E, Oliver V, Botella-Estrada R, Moreno-Picot S, Guillén C,
Fortea JM. Clinicopathological analysis of 1571 cutaneous malignant
melanomas in Valencia, Spain: factors related to tumour thickness.
Acta Derm Venereol. 2006; 86(1):50-6.
Moreira J, Moreira E, Azevedo F, Mota A. Cutaneous malignant
melanoma: a retrospective study of seven years (2006-2012). Acta
Med Port. 2014; 27(4):480-488.
Mbuagbaw J, Pisoh C, et al. Malignant Melanoma In Cameroon.
Internet J Surg. 2006;1:1 –5. 34.
Chalya PL, Gilyoma JM, et al. Dermatological malignancies at a
university teaching hospital in North-Western Tanzania: a retrospective
review of 154 cases. Tanzania J Health Res. 2012;1:1 –9
Lodder JV, Simson W, Becker PJ. Malignant melanoma of the skin in
black South Africans: A 15-year experience. S Afr Med J.
;48(3):76–9
Pitché P, Napo-Koura G, Tchangai-Walla K. Epidemiology of
melanoma in Togo. Int J Dermatol. 2005;44 (Suppl. 1:44–5.
Emegoako CD, Okoli CC, Okoye O. Malignant melanoma in a Nigerian
tertiary hospital. Orient J Med. 2016;28:49–53.
Scolyer RA, Judge MJ, Frishberg DP, et al. Data set for pathology
reporting of cutaneous invasive melanoma: Recommendations from the
International Collaboration on Cancer Reporting (ICCR). Am J Surg
Pathol. 2013;37: 1797–814.
Tokura Y, Bastian BC, Duncan L. Acral lentiginous-melanoma. In: PE
LB, Burg G, Weedon D, Sarasin A, editors. WHO Classification of
Tumours; Pathology and Genetics of Skin Tumours. 4th ed. Lyon: IARC
press; 2006. p. 73–5.

Downloads
Published
Issue
Section
License
Copyright (c) 2024 International Archives of BioMedical and Clinical Research

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors are required to sign and submit the completed “Copyright transfer Form” upon acceptance of publication of the paper. This is determined by a publishing agreement between the author and International Archives of Biomedical and Clinical Research. These rights might include the right to publish, communicate and distribute online. Author(s) retain the copyright of their work. International Archives of Biomedical and Clinical Research supports the need for authors to share, disseminate and maximize the impact of their research.