Epidemiological and Histopathological Profile of Malignant Melanoma: An Institutional Based Study

Authors

  • Sudhir R Raghuwanshi Associate Professor, Department of Pathology, Grant Government Medical College and Sir J.J. Group of Hospitals, Mumbai, Maharashtra, India. Author

DOI:

https://doi.org/10.21276/4s2wj597

Keywords:

Epidemiology, Melanoma, histopathological

Abstract

Background: The present study was aimed to analyze the epidemiological and histopathological data of patients with malignant melanoma (MM).

Materials and Methods: The present study retrospectively analyzed the data of 85 patients who were histopathologically diagnosed with malignant melanoma (MM). Data abstracted included age, sex, anatomic site and whether it was a primary or metastatic site. Breslow thickness in millimetres, Clark level of invasion, presence of ulceration and melanoma subtype were also evaluated.

Results: The study included 85 patients in total with 44 (56.4%) male and 37 (43.6%) female. Median age of the patients was 62.50 years (range: 27 - 84 years). Of the patients, 96.4% (n=82) had cutaneous melanoma, 3% mucosal melanoma. . Ninety five percent of cutaneous melanomas were located on acral sites, most commonly the foot (87%) and the most common histopathological subtype was acral lentiginous. Eighty four percent presented with a Breslow thickness over 4 mm (median 9 mm).

Conclusion: Malignant melanoma data are also important for the optimal utilization of effective methods and healthcare resources to prevent the disease.

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References

Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffel DJ, Wolff K.

Fitzpatrick's Dermatology in General Medicine, 8th edition. McGraw-Hill

company. 2012. Bailey EC, Sober AJ, Tsao H, Mihm Jr MC, Johnson

TM. Chapter 124: Cutaneous melanoma.

Stubblefield J, Kelly B. Melanoma in non-Caucasians. Surg Clin N Am.

; 94:1115–6.

Asuquo ME, Ebughe G. Cutaneous cancers in Calabar, southern

Nigeria. Dermatol Online J. 2009;15(4):11.

Lodder JV, Simson W, Becker PJ. Malignant melanoma of the skin in

black South Africans: A 15-year experience. S Afr Med J.

;48(3):76–9

Weber AL, Nunes DH, Souza Filho JJ, Pinto CJC. Assessment of 496

pathological reports of melanoma diagnosed in the city of Florianopolis,

SC, Brazil. An Bras Dermatol. 2007;82:227-32

Ferrari Júnior NM, Muller H, Ribeiro M, Maia M, Sanches Júnior JA.

Cutaneous melanoma: descriptive epidemiological study. São Paulo

Med J. 2008;126:41-7

Bonfá R, Bonfá R, Furian RD, Bonamigo RR, Duro KM, Zelmanowicz

AM. Early diagnosis of cutaneous melanoma: an observation in

southern Brazil. An Bras Dermatol. 2011;86:215-21.

Dimatos DC, Duarte FO, Machado RS, Vieira VJ, Vasconcellos ZAA,

Bins-Ely J, et al. Melanoma cutâneo Brasil. Arq Cat Med. 2009;38(Supl.

:14-9.

Tishkoff SA, Reed FA, et al. The genetic structure and history of

Africans and African Americans. Science. 2009;324(5930):1035–44.

Chang AE, Karnell LH, Menck HR. The National Cancer Data Base

report on cutaneous and noncutaneous melanoma: a summary of

,836 cases from the past decade: the American College of Surgeons

Commission on Cancer and the American Cancer Society. Cancer.

; 83(8):1664-1678.

Özçelik S, Akyol M. Epidemiology of Melanoma. Turkderm.

;41(2):1-5

Özdemir F. Malignant Melanoma. Turkiye Klinikleri J Dermatol-Special

Topics. 2013; 6(3):24-43.

Tas F, Kurul S, Camlica H, Topuz E. Malignant melanoma in Turkey: a

single institution's experience on 475 cases. Jpn J Clin Oncol. 2006;

(12):794-9.

Karasoy A, Karsidag S, Tatlidere S, Ugurlu K, Özkaya Ö, Kuan I et al.

Our Experience For 65 Patients with Malignant Melanoma in 13 years:

a retrospective study. Turk Plast Surg. 2004; 12(3):153-7.

Simsek T, Sönmez A, Ahmet Demir A, Tayfur V, Güneren E, Eroglu L,

Yildiz L. Our Clinical Experience in 84 patients with cutaneous

malignant melanoma. Turk Plast Surg. 2011; 19(3):113-6.

Kulahci Y, Zor F, Öztürk S, Eski M, Deveci M, Isik S. Retrospective

analysis of 79 malign melanoma patients. Turk Plast Surg. 2007;

(1):15-9

Amerio P, Manzoli L, Auriemma M, Carbone A, Proietto G, Angelucci

D, Tulli A. Epidemiology and clinical and pathologic characteristics of

cutaneous malignant melanoma in Abruzzo (Italy). Int J Dermatol.

; 48(7):718-22.

van der Velden HM, van Rossum MM, Blokx WA, Boezeman JB,

Gerritsen MJ. Clinical characteristics of cutaneous melanoma and

second primary malignancies in a dutch hospital-based cohort of

cutaneous melanoma patients. Dermatol Res Pract. 2009; 479183:1-8.

Nagore E, Oliver V, Botella-Estrada R, Moreno-Picot S, Guillén C,

Fortea JM. Clinicopathological analysis of 1571 cutaneous malignant

melanomas in Valencia, Spain: factors related to tumour thickness.

Acta Derm Venereol. 2006; 86(1):50-6.

Moreira J, Moreira E, Azevedo F, Mota A. Cutaneous malignant

melanoma: a retrospective study of seven years (2006-2012). Acta

Med Port. 2014; 27(4):480-488.

Mbuagbaw J, Pisoh C, et al. Malignant Melanoma In Cameroon.

Internet J Surg. 2006;1:1 –5. 34.

Chalya PL, Gilyoma JM, et al. Dermatological malignancies at a

university teaching hospital in North-Western Tanzania: a retrospective

review of 154 cases. Tanzania J Health Res. 2012;1:1 –9

Lodder JV, Simson W, Becker PJ. Malignant melanoma of the skin in

black South Africans: A 15-year experience. S Afr Med J.

;48(3):76–9

Pitché P, Napo-Koura G, Tchangai-Walla K. Epidemiology of

melanoma in Togo. Int J Dermatol. 2005;44 (Suppl. 1:44–5.

Emegoako CD, Okoli CC, Okoye O. Malignant melanoma in a Nigerian

tertiary hospital. Orient J Med. 2016;28:49–53.

Scolyer RA, Judge MJ, Frishberg DP, et al. Data set for pathology

reporting of cutaneous invasive melanoma: Recommendations from the

International Collaboration on Cancer Reporting (ICCR). Am J Surg

Pathol. 2013;37: 1797–814.

Tokura Y, Bastian BC, Duncan L. Acral lentiginous-melanoma. In: PE

LB, Burg G, Weedon D, Sarasin A, editors. WHO Classification of

Tumours; Pathology and Genetics of Skin Tumours. 4th ed. Lyon: IARC

press; 2006. p. 73–5.

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Published

20.03.2024

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Section

ORIGINAL ARTICLES ~ Pathology

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