A Cross-sectional Study: Bone Markers in Different Body Mass Index Groups of Newly Diagnosed Breast Cancer Females in Karachi, Pakistan

  • Shamim A. Qureshi Department of of Biochemistry, University of Karachi, Karachi-75270, Pakistan.
  • Shamsa K. Udani Department of of Biochemistry, University of Karachi, Karachi-75270, Pakistan
  • Mishghan Zehra Department of of Biochemistry, University of Karachi, Karachi-75270, Pakistan.
  • Tooba Batool Department of of Biochemistry, University of Karachi, Karachi-75270, Pakistan.
  • Tooba Lateef Department of of Biochemistry, University of Karachi, Karachi-75270, Pakistan.
  • Farooq Ghani Department of Pathology and Laboratory Medicine, Aga Khan University and Hospital, Karachi-74800, Pakistan.
  • Muhammad Bilal Azmi Department of Biochemistry, Dow Medical College, Dow University of Health Science, Karachi-74600, Pakistan.
Keywords: Breast cancer, vitamin D deficiency, bone markers.

Abstract

Background: Pakistan is a big victim of breast cancer and vitamin D deficiency. Interestingly, bones are the common site of breast cancer metastasis and vitamin D deficiency makes this condition more worst. The present study designed to estimate bone markers and minerals in different BMI groups of newly diagnosed breast cancer patients. Materials & Methods: diagnosed breast cancer females were approached and their characteristics including age, marital status, menstrual & family history, receptor status, tumor grade & type and presence of metastasis were noted from their medical reports. Whereas bone markers and minerals viz., alkaline phosphatase (ALP), bone specific ALP (BALP), vitamin D, carboxyl terminal collagen crosslinks (CTX), human epidermal growth factor 2 receptor (Her2) protein, albumin, calcium (Ca), phosphorus (P) and magnesium (Mg) were estimated plus body mass index (BMI) measured. Results: Most of the recruited females found aged less than 50 yrs, wedded, belonged to plump to obese BMI groups, had invasive ductal carcinoma, expressed triple positive receptor status and tumor grade II. Very few had metastasis and family history of breast cancer. Patients in all BMI groups showed insufficient level of vitamin D but normal levels of ALP, Ca, Mg, P, albumin, Her2 protein and CTX. Whereas Ca and BALP found slightly low in underfed BMI group patients. Conclusion: The results concluded and recommended that vitamin D levels must be monitored in breast cancer patients before and after treatment otherwise it will decrease more and may affect other bone markers. 

 

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Published
2018-03-21
How to Cite
1.
Qureshi S, Udani S, Zehra M, Batool T, Lateef T, Ghani F, Azmi M. A Cross-sectional Study: Bone Markers in Different Body Mass Index Groups of Newly Diagnosed Breast Cancer Females in Karachi, Pakistan. IABCR [Internet]. 21Mar.2018 [cited 11Dec.2018];4(1):141-5. Available from: https://iabcr.org/index.php/iabcr/article/view/293