Role of Teriparatide Vs Zoledronic Acid in Osteoporosis as well as in Pathological Fractures due to Osteoporosis

Authors

  • Vinod Kumar Nagar Assistant Professor Orthopedics, PMCH, Udaipur, Rajasthan Author
  • Vishal Shinde Assistant Professor Orthopedics, PMCH, Udaipur, Rajasthan Author

DOI:

https://doi.org/10.21276/axsayh24

Keywords:

Teriparatide, cZoledronic Acid, Osteoporosis

Abstract

Background-Present prospective study is intended to compare role of Teriparatide and Zoledronic acid in osteoporosis as well as in pathological fracture due to osteoporosis so as to help elderly postmenopausal women to combat with osteoporosis & complications arising due to it.

Material & Methods-This study is carried out in Pacific Medical College & Hospital,Udaipur in the department of orthopedics from Dec. 2107 to June 2019.Total of 100 women were included at the time of beginning but 20 women were lost in the follow up due to various reasons.51 patients of group 1 were given Zoledronic acid & 29 patients were given Teriparatide.Patients were evaluated upto 12 months at regular intervals. Serial DEXA scans were done,assessment & comparison were done accordingly.

Conclusion-Treatment of osteoporosis is multimodal with no definitive single molecule available.This study compared Zoledronic acid & Teriparatide.Although T-score has nearly the same value but our study resulted in increase BMD score & fewer side effects by the use of Teriparatide so it is concluded that patient with very low BMD requires treatment with Teriparatide.

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References

Meenal Jain et al IJMHS.net July 2017 –A prospective comparative study of efficacy of Zoledronic acid vs Teriparatide on BMD via Dexa scan in postmenopausal osteoporosis.

Cosman F, Eriksen Ef et al –effects of IV Zoledronic acid plus subcutaneous Teriparatide in postmenopausal osteoporosis. J Bone Mineral Res.2011;26:503-511 [Pubmed].

Cosman F, Nieves J, Zion M, Woelfert L , Luckey M. et al –Daily & cyclic parathyroid hormone in women receiving Alendronate .N Engl J Med.2005;353,566-575. [Pubmed].

Black DM, Greenspan SL, Ensurd KE et al –The effects of parathyroid hormone & alendronate alone or in combination in postmenopausal osteoporosis, N Engl J Med 2003;349:1207-1215.[Pubmed].

Neer RM, Arnaud CD, Zanchetta JR et al- Effect of parathyroid hormone on fractures & BMD in postmenopausal women with osteoporosis. N Engl J Med.2001;344:1434-1441. [Pubmed].

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Published

20.03.2024

Issue

Section

ORIGINAL ARTICLES ~ Orthopaedics

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