Assessment of Efficacy of Various Treatment Regimes in Patients with Typhoid Fever: A Prospective Study
Background: Typhoid fever is caused by Salmonella enterica serovar Typhi (S typhi), a Gram negative bacterium. Typhoid fever is among the most common febrile illnesses encountered by practitioners in developing countries. Hence; we planned the present study to evaluate the efficacy of various treatment regimes in treating patients with typhoid fever.
Materials & Methods: The present study included assessment of efficacy of different treatment regimes in treating patients with typhoid fever. A total of 40 patients were included in the present study and were broadly divided into two study groups with 20 patients each group. Group 1 included patients who were treated ceftriaxone therapy while group 2 included patients who were treated with chloramphenicol. Bacteriological culturing of the blood, stool and urine samples was done for confirming the diagnosis at the start of the treatment. Repetition of the blood and stool culture was done on day 5 and day 12 after the discharge of the patient. All the results were analyzed by SPSS software. Results: Complete clinical cure occurred in 17 and 19 patients of group 1 and group 2 respectively. Positive blood culture for S. typhi on day 5 occurred in 0 and 10 days of group 1 and group 2 patients respectively. Conclusion: In treating patients with typhoid fever, Ceftriaxone could be safely used.
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