A Comparative Analysis on Anesthetic Requirement and Peri-Operative Hemodynamic Stress Response after a Single Dose of Dexmedetomidine and Fentanyl: A Hospital Based Study
DOI:
https://doi.org/10.21276/djm5x151Keywords:
HEMODYNAMIC STRESS RESPONSE, LARYNGOSCOPIC, INTUBATIONAbstract
Introduction:- Fentanyl which is a short acting, synthetic opioid delivers cardiac stability at therapeutic doses and effectively blocks the sympathetic stress response to surgical stimulus. It also provides further hemodynamic stability. The Bispectral Index (BIS) is a derived electroencephalographic parameter. It has been widely validated as a monitor for depth of anesthesia.
Methodology:- 99 patients of either sex, between age Group of 18 – 60 years, ASA Grade I and Grade II, scheduled for surgery under general anesthesia were randomly selected and included in this study. The duration of study was over a period of one year. This study was conducted in the Dept. of Anaesthesiology, Ananta Institute of Medical Sciences and Research Centre.
Result:- In this study we were included two groups. 34% male & 66% female were included in Group I. While in Group 2 33% male & 67% female were included. Baseline characteristics of both the groups were not significantly different. There were no significant differences in age & sex& mean duration of surgery between two groups.(p>0.05 )
Conclusion:- This study colludes that, it was inferred that Fentanyl can also help to attenuate laryngoscopic stress response, as the rise in hemodynamics after laryngoscopy and intubation was within the normal limits of heart rate.
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Nermin Gogus, Belgin Akan, , Nurten Serger, Mustafa Baydar: The comparison of the effects of Dexmedetomidine, Fentanyl and Esmolol on prevention of hemodynamic response to intubation, Rev Bras Anesthesiology,2014;64(5):314-319.
Manorama Singh: Stress response and Anesthesia, Indian J.Anesthesia, 2003;47(6):427-434.
Sagar Gandhi, Vigya Goyal, Krishna Prabha Radhakrishnan,Mahesh Balakrishnan: Comparison of Dexmedetomidine with Fentanyl in attenuation of pressor response during laryngoscopy and intubation, 2014 ,IOSR Journal of Pharmacy, volume 4, Issue 2,pg 28-38.
J.Whirley-Diaz, S.M.Helfman, E.A.Delisser: Bolus esmolol treatment of intraoperative tachycardia Due to surgical stimulation,Anesthesia,1991;volume 46,pages 220-223
25. Spencer S. Liu: Effects of Spectral Index Monitoring on ambulatory anesthesia, Anesthesiology 2004; 101:311-5.
Arpita Laha, Sarmila Ghosh, Susanta Sarkar: Attenuation of symapthoadrenal response and anesthetic requirement by Dexmedetomidine, Anesthesia Essays and Researches,2013;7:65-70.
Nermin Gogus, Belgin Akan, , Nurten Serger, Mustafa Baydar: The comparison of the effects of Dexmedetomidine, Fentanyl and Esmolol on prevention of hemodynamic response to intubation, Rev Bras Anesthesiology,2014;64(5):314-319.
C.J.Lawrence and S.De Lange: Effects of a single pre-operative Dexmedetomidine dose on isoflurane requirements and peri-operative hemodynamic stability, Anesthesia,1997;52,pages 736-744.
Jin Woo Choi, Jin-Deok Joo, Dae-Woo Kim, Jang-Hyeok In, So-Young Kwon, Kwonhui Seo, Donggyu Han, Ga-Young Cheon, and Hong Soo Jung: Comparison of an intraoperative infusion of Dexmedetomidine, Fentanyl and Remifentanil on perioperative hemodynamics, sedation quality, and post-operative pain control, Journal of Korean medical science 2016;31:1485-1490.
Robert K Stoelting: opioid agonist and antagonists, pharmacology and physiology in anesthetic practice, 3rd edition, Lippincott Raven 1999;103-05.
Robert K Stoelting: Pharmacology and physiology in anesthetic practice,3 rd edition. Lippincott Raven publishers(United States of America) 1999;628:33.
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