Assessment of Liver Disorders in Patients of Type 2 Diabetes Mellitus: A Hospital Based Study

  • Ramesh Kumar Goenka Assistant Professor, Dept. of General Medicine, KIMS, Bhubaneswar
Keywords: Dyslipidaemia, Liver disorders, Type 2 DM

Abstract

Background: Non-alcoholic steatohepatitis (NASH) is commonly associated with type 2 diabetes mellitus (DM). Prevalence of NASH in type 2 DM has not been well studied and there is an epidemic rise in type 2 DM in Asian and Western populations. Its association with chronic liver disease in the form of NASH makes it an important health problem. Hence, we have studied its prevalence and correlation of biochemical parameters with histological grades of non-alcoholic fatty liver disease (NAFLD) in otherwise asymptomatic type 2 DM patients.

 Materials & Methods: One hundred and twenty-five individuals were screened. N=30 individuals were excluded due to history of alcohol intake or liver disease as a result of other causes. N=95 non-alcoholic individuals with type 2 DM underwent abdominal ultrasonography (US abdomen). N=28 patients had evidence of fatty liver on US abdomen, and 16 of these 28 patients underwent liver biopsy.

Results: Out of 125 patients enrolled with the suspicion of Nonalcoholic Fatty Liver Disease (NAFLD) and Non-alcoholic steatohepatitis in patients of Type 2 Diabetes Mellitus, female patients were 70 (56%) and male patients 55 (44%). The prevalence of NAFLD was found to be more in females n=40 than males n=30. N=16 patients were undergone liver biopsy for the suspicion NASH. Out of 22 patients suspected, only 9 patients were found to be having NASH.

Conclusion: We conclude that the prevalence of NASH is high in type 2 DM patients and liver biopsy is the only investigation to differentiate between non-alcoholic fatty liver and steatohepatitis.

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References

1. Andrea E. Reid. Nonalcoholic Fatty Liver Disease. Mark Feldman, Lawrence S. Frieddman, Lawrence J. Brandt, editors. Sleisenger and Fordtran’s Gastrointestinal And Liver Disease, 9th ed, Philadelphia, 2010. p 1401-1411.
2. Stephen H. Caldwell, Curtis K. Argo. Non-alcoholic Fatty Liver Disease and Nutrition. James S. Dooley, Anna S.F. Lok, Andrew K. Burroughs, E. Jenny Heathcote, editors. Sherlock’s Diseases of the Liver and Biliary System, 12th ed, West Sussex,2011.p 546-562.
3. Yogesh K Chawla, Sunil Taneja. Non-Alcoholic Fatty Liver Disease. YP Munjal, SK Sharma, editors. API Textbook of Medicine, Ninth ed, Mumbai, 2012. p 885-887.
4. AK Agarwal, Vineet jain, Sumeet Singla, BP Baruah, Vivek Arya, Rajbala Yadav. Prevalence of non-alcoholic fatty liver disease and its correlation with coronary risk factors in patients with type 2 diabetes. JAPI 2011, 59: 351-354.
5. Farrell GC, Larter CZ. Nonalcoholic Fatty Liver Disease: from Steatosis to cirrhosis. Hepatology 2006;43:S00-S112.
6. Lazo M, Clark JM., The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis 2008;28:39-50.
7. Bellentani S, Scaglioni F, Marino M, Bedogni G., Epidemiology of non-alcoholic fatty liver disease. Dig Dis 2010;28:155-61.
8. Duseja A., Nonalcoholic fatty liver disease in India - a lot done, yet more required. Indian J Gastroenterol 2010;29:217-25.
9. Singh SP, Nayak S, Swain M, et al. Prevalence of non alcoholic fatty liver disease in coastal eastern India: A preliminary ultrsonographic survey. Trop Gastroenterol 2004;25:76-9.
10. Gupte P, Amarapurkar D, Agal S, et al. Non-alcoholic steatohepatitis in type 2 diabetes mellitus. J Gastroenterol Hepatol 2004;19:854–858
11. Uchil D, Pipalia D, Chawla M, Patel R, Maniar S, Narayani, Juneja A. Non-alcoholic fatty liver disease (NAFLD)--the hepatic component of metabolic syndrome. J Assoc Physicians India 2009;57:201-4.
Published
2018-03-21
How to Cite
1.
Goenka R. Assessment of Liver Disorders in Patients of Type 2 Diabetes Mellitus: A Hospital Based Study. IABCR [Internet]. 21Mar.2018 [cited 11Dec.2018];4(1):65-7. Available from: https://iabcr.org/index.php/iabcr/article/view/269