A Prospective Study on Klinefelter Syndrome: A Basket of Multiple Systemic Disorders in a Tertiary Care Hospital

  • K R Sharma Assistant Professor; Dept. of General Medicine, Pacific Medical College & Hospital, Bhillon ka Bedla, Pratap Pura, Girwa, Near NH- 76, Udaipur, Rajasthan, India.
  • Samil Sajal Assistant Professor; Dept. of General Medicine, Pacific Medical College & Hospital, Bhillon ka Bedla, Pratap Pura, Girwa, Near NH- 76, Udaipur, Rajasthan, India.
  • Harshit Sharma Clinical Embryologist, IVF Center SMS Medical College Jaipur, India
  • Smita Verma Medical Officer, Human Fertility Center RNT Medical College, Udaipur India.
  • Y K Bolya Professor & Head, Dept. of General Medicine, Pacific Medical College & Hospital, Bhillon ka Bedla, Pratap Pura, Girwa, Near NH- 76, Udaipur, Rajasthan, India.
Keywords: Klinefelter Syndrome, Infertility, Chromosomal disorder.

Abstract

Background: When one or more extra X chromosome is added to a normal male karyotype (46-XY), then a new aneuploidy appears called Klinefelter Syndrome (KS). Every day approximately more than 50 new such cases are added in the male population of India. Traditionally they are lean, thin, tall, azoospermic, hypogonadic, infertile males with low social and educational profile. As the age advances level of testosterone decreases and many new symptoms of multiple systemic disorders appear in these cases. Methods: A well designed questionnaire of infertile males attending the above- mentioned OPD’s was filled with history, clinical examination and semen analysis (twice as per the WHO criteria).  Results: In our series of 500 azoospermic males, we encountered 56 classical KS cases (11.2 %) of 47-XXY karyotype, who were hypergonadotrophic hypogonadic and diagnosed with multiple diseases when evaluated in detail. Conclusions: Hence, every KS must receive androgen replacement therapy, which should begin at puberty and continue for lifelong that helps in preventing the development of high comorbidity rate and premature deaths because these are very high in such condition as compared to normal male population.

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Published
2018-03-20
How to Cite
1.
Sharma K, Sajal S, Sharma H, Verma S, Bolya Y. A Prospective Study on Klinefelter Syndrome: A Basket of Multiple Systemic Disorders in a Tertiary Care Hospital. IABCR [Internet]. 20Mar.2018 [cited 22Jul.2018];4(1):35-8. Available from: https://iabcr.org/index.php/iabcr/article/view/260