Roflumilast therapy in COPD − Update and Trials

  • Om Prakash Giri Department of Pulmonary Medicine, Darbhanga Medical College and Hospital, Darbhanga
  • Vishal Prakash Giri Department of Pharmacology, Teerthanker Mahaveer Medical College & Research Centre, Moradabad
Keywords: Anti-inflammatory; Chronic obstructive pulmonary disease; Phosphodiesterase 4 inhibitor; Roflumilast

Abstract

Chronic Obstructive Pulmonary Disease (COPD) represents an important public health challenge that is both preventable and treatable. Pharmacological treatment regimen for COPD needs to be patient specific. Hence  management of  COPD    should  be  based  on  strategy  considering  both  disease  impact  and  future  risk  of  disease  progression ( especially of  exacerbation ). Risk of exacerbations significantly increases in GOLD 3 and GOLD 4 COPD. Exacerbations  increase  the   decline in  lung function , deteorriation  in  health  status  and  risk   of  death.

Roflumilast   is   a   phosphodiesterase-4 (PDE4) inhibitor. It reduces   risk of moderate to severe   exacerbations in patients   of   GOLD 3   & GOLD 4   COPD. It  has  no  direct  bronchodilator  activity, although it  has  been  shown  to  improve  FEV1  in  patients treated  with   inhaled  long-acting  bronchodilator. Adverse  effects  may occur  early during the  treatment  but  these  are  reversible  and  diminish  overtime  with  continued  treatment .

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Published
2015-09-03
How to Cite
1.
Giri O, Giri V. Roflumilast therapy in COPD − Update and Trials. IABCR [Internet]. 3Sep.2015 [cited 24Jul.2019];1(1):31-6. Available from: https://iabcr.org/index.php/iabcr/article/view/249