Ofloxacin and Nitrofurantoin sensitivity pattern In Patients of Urinary Tract Infection (UTI) at a tertiary care teaching hospital

  • Dharmesh Devmurari Department of Microbiology, Gujrat Adani Institute of Medical Sciences, Bhuj, Gujarat.
  • Chand Miyaan Kamal Department of Pharmacology, SMMH Government Medical College, Saharanpur, India
  • Shambhu Nath Singh Department of Pharmacology, Darbhanga Medical College and Hospital, Bihar
  • Amit Kumar Department of Pharmacology, Teerthanker Mahaveer Medical College
Keywords: Nitrofurantoin, Ofloxacin, Antimicrobial agents, Sensitivity

Abstract

Introduction: UTIs are the second most common bacterial infection in present population. Women are more prone to UTI than Male.  Uropathogenic Escherichia coli is responsible for >80% of community acquired UTIs.

Aims: The present study was carried out to compare sensitivity / Resistance between Ofloxacin and Nitrofurantoin in UTI patients.

Methods: This was a prospective, cross-sectional, observatory study conducted on patients (n = 200) suffering from Urinary Tract Infection from March 2014 to February 2015 at the Department of Microbiology and Department of Pharmacology, Teerthanker Mahaveer Medical College and Research Centre (TMMC & RC), at a tertiary care teaching hospital, in Moradabad, Uttar Pradesh, India.

Results: UTI was much more common in females (61%, n=122) than in males (39%, n=78).   The most common organism isolated was E. coli, 47%(n=94),  followed by Klebsiella 34.5%(n=69), staphylococcus 7.5%(n=15), Proteus, pseudomonas 4%(n=8)  and enterococcus 3%(n=6). E. coli was highly sensitive to the Ofloxacin 18% (n=36).

Conclusion: Sensitivity pattern of the antimicrobial was found to be more in Nitrofurantoin (57%) was found to be more sensitive than Ofloxacin (40.5%) for the treatment of UTI.

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Published
2015-09-03
How to Cite
1.
Devmurari D, Kamal C, Singh S, Kumar A. Ofloxacin and Nitrofurantoin sensitivity pattern In Patients of Urinary Tract Infection (UTI) at a tertiary care teaching hospital. IABCR [Internet]. 3Sep.2015 [cited 24Jul.2019];1(1):17-2. Available from: https://iabcr.org/index.php/iabcr/article/view/245