Ofloxacin and Nitrofurantoin sensitivity pattern In Patients of Urinary Tract Infection (UTI) at a tertiary care teaching hospital

  • Dharmesh Devmurari Department of Microbiology, Gujrat Adani Institute of Medical Sciences, Bhuj, Gujarat.
  • Chand Miyaan Kamal Department of Pharmacology, SMMH Government Medical College, Saharanpur, India
  • Shambhu Nath Singh Department of Pharmacology, Darbhanga Medical College and Hospital, Bihar
  • Amit Kumar Department of Pharmacology, Teerthanker Mahaveer Medical College
Keywords: Nitrofurantoin, Ofloxacin, Antimicrobial agents, Sensitivity


Introduction: UTIs are the second most common bacterial infection in present population. Women are more prone to UTI than Male.  Uropathogenic Escherichia coli is responsible for >80% of community acquired UTIs.

Aims: The present study was carried out to compare sensitivity / Resistance between Ofloxacin and Nitrofurantoin in UTI patients.

Methods: This was a prospective, cross-sectional, observatory study conducted on patients (n = 200) suffering from Urinary Tract Infection from March 2014 to February 2015 at the Department of Microbiology and Department of Pharmacology, Teerthanker Mahaveer Medical College and Research Centre (TMMC & RC), at a tertiary care teaching hospital, in Moradabad, Uttar Pradesh, India.

Results: UTI was much more common in females (61%, n=122) than in males (39%, n=78).   The most common organism isolated was E. coli, 47%(n=94),  followed by Klebsiella 34.5%(n=69), staphylococcus 7.5%(n=15), Proteus, pseudomonas 4%(n=8)  and enterococcus 3%(n=6). E. coli was highly sensitive to the Ofloxacin 18% (n=36).

Conclusion: Sensitivity pattern of the antimicrobial was found to be more in Nitrofurantoin (57%) was found to be more sensitive than Ofloxacin (40.5%) for the treatment of UTI.


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1. Foxman B, Freichs RR. Epidemiology of urinary tract infection.II. Diet, clothing, and urination habits. Am J Public Health. 1985; 17:1314-7.
2. Ronald A. The etiology of urinary tract infection: traditional and emerging pathogens. Am J Med 2002; 113(Suppl 1):14S–19S
3.Lucas MJ, Cunningham FC. Urinary tract infection during pregnancy. ClinObstatGynecol.1993; 36:855.
4. Davidson J &Bayles C; medical disorder in obstetric practice. Ed by Micheal de Swiet 4TH edition; Blackwell publishing . 2002; 198-267,
5. Tanagho Emil A, Mcaninch, Jack W. Editors . smith`s general Urology. United States of America: McGraw-Hill Companies Inc. Bacterial infection of the genitourinary tract. 2004; 203-227.
6. Hooton TM, Stamm WE. Diagnosis and treatment of uncomplicated urinary tract infection. Infect Dis Clin North Am 1997; 11: 551-581. [PubMed]
7. Gupta K, Scholes D, Stamm WE. Increasing prevalence of antimicrobial resistance among uropathogens causing acute uncomplicated cystitis in women. JAMA 1999; 281: 736-738. [PubMed]
8. American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 91: treatment of urinary tract infections in non-pregnant women. Obstet Gynecol 2008; 111(3):785–94.
9. Hooton TM, Running K, Stamm WE. Single-dose therapy for cystitis in women: a comparison of trimethoprim-sulfamethoxazole, amoxicillin, and cyclacillin. JAMA 1985; 253: 387-390. [PubMed]
10. Stamey TA, Fair WR, Timothy MM, Millar MA, Mihara G, Lowery YC. Serum versus urinary antimicrobial concentrations in cure of urinary-tract infections. N Engl J Med 1974; 291: 1159-1163. [PubMed]
11. Cunha, B.A. Nitrofurantoin: An update. Obstet. Gynecol. Surv. 1989, 44, 399-406.
12. Kashanian, J.; Hakimian, P.; Blute, M., Jr.; Wong, J.; Khanna, H.; Wise, G.; Shabsigh, R. Nitrofurantoin: The return of an old friend in the wake of growing resistance. BJU Int. 2008, 102, 1634–1637.
13. Mazzulli, T.; Skulnick, M.; Small, G.; Marshall, W.; Hoban, D.J.; Zhanel, G.G.; Finn, S.; Low, D.E. Susceptibility of community Gram-negative urinary tract isolates to mecillinam and other oral agents. Can. J. Infect. Dis. 2001, 12, 289–292.
14. Nelson, JM.; Chiller, TM. Powers, JH. Angulo, FJ. (Apr 2007). "Fluoroquinolone-resistant Campylobacter species and the withdrawal of fluoroquinolones from use in poultry: a public health success story". Clin Infect Dis 44 (7): 977–80. doi:10.1086/512369. PMID 17342653.
15. Jha N, Bapat S K. A study of sensitivity and resistance of pathogenic microorganisms causing UTI in Kathmandu valley. Kathmandu University Medical Journal. 2005; Vol. 3, No. 2, Issue 10, 123-129.
16. Dash M, Padhi S, Mohanty I, Panda P, Parida B. Antimicrobial Resistance in Pathogens Causing Urinary Tract Infections in a Rural Community of Odisha. India J Family Community Med. 2013; 20: 20-26.
17. Thapa P et al. Causative agents and susceptibility of antimicrobials among suspected females with urinary tract infection in tertiary care Hospitals of western Nepal. Journal of Chitwan Medical College. 2013; 3(4): 16-19.
18. Sharma AR, Bhatta DR, Shrestha J, Banjara MR. Antimicrobial susceptibility pattern of Escherichia coli isolated from uninary tract infected patients attending Bir hospital, Nepal. J Sci Technol. 2013;14(1):177–84.
How to Cite
Devmurari D, Kamal CM, Singh SN, Kumar A. Ofloxacin and Nitrofurantoin sensitivity pattern In Patients of Urinary Tract Infection (UTI) at a tertiary care teaching hospital. Int Arch BioMed Clin Res [Internet]. 2015Sep.3 [cited 2020Aug.12];1(1):17-2. Available from: https://iabcr.org/index.php/iabcr/article/view/245