Role of Topical Acetic Acid in Comparison to Gentamicin for the Management of Chronic Suppurative Otitis Media

  • Kirti Vishwakarma Department of Pharmacology, Teerthanker Mahaveer Medical College & Research Centre, Moradabad
  • Farhan Ahmad Khan Department of Pharmacology, Teerthanker Mahaveer Medical College & Research Centre, Moradabad.
  • Sheikh Nizamuddin Department of ENT, Teerthanker Mahaveer Medical College & Research Centre, Moradabad.
  • Preeti Singh Department of Pharmacology, Teerthanker Mahaveer Medical College & Research Centre, Moradabad.
  • Lalendra Yadav Department of Pharmacology, Muzaffarnagar Medical College & Research Centre, Muzaffarnagar.
Keywords: Chronic Suppurative Otitis Media, Gentamicin, Acetic Acid

Abstract

Introduction: Chronic Suppurative Otitis Media (CSOM) is one of the diseases resistant to current antibiotics; persisting for more than two week; and capable of causing severe discharge, tympanic membrane perforation and deafness. This may cause distress and affect their quality of life and productivity.

Aims: To assess the role of topical Acetic Acid in comparison to Gentamycin for management of CSOM.

Methods: It was a Randomized, open label study. Patients diagnosed as CSOM (safe type) were randomly divided into two groups, group I - topical 1.5% Acetic acid and group II - topical 0.3% Gentamicin sulphate in a dose of three otic drops thrice daily. Follow up was done every week for two weeks and was compared on the basis of otological symptoms score.

Results: The mean difference of otological symptom score at day 7 and day 14 from baseline in Group I was 1.90±1.01 and 3.40±1.08; and in Group II 1.96±0.57 and 3.12±0.74; p<0.05. Among the study groups, reduction of otological symptom scores at day 7 (Group I =3.22±1, Group II=2.66±1.76; p=0.14) and at day 14 (Group I = 1.72±1.76, Group II= 1.50±1.79; p=0.56) respectively. Also, “Treatment success” seen in 46 (92%) patients in the Acetic acid group and 44 (88%) patients in Gentamicin sulphate group. Moreover, cost of the treatment for Acetic acid was 102.94 and for Gentamicin sulphate was Rs.160.25 per person.

Conclusion: Topical Acetic acid was found to be equally effective to Gentamicin sulphate for the treatment of CSOM.

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Published
2015-09-03
How to Cite
1.
Vishwakarma K, Khan FA, Nizamuddin S, Singh P, Yadav L. Role of Topical Acetic Acid in Comparison to Gentamicin for the Management of Chronic Suppurative Otitis Media. Int Arch BioMed Clin Res [Internet]. 2015Sep.3 [cited 2019Oct.17];1(1):13-6. Available from: https://iabcr.org/index.php/iabcr/article/view/244
Section
ORIGINAL ARTICLES ~ General Surgery