Amygdala pharmacology and crime behavior, dysfunctions to be considered as a disease?

  • M. Luisetto Applied Pharmacologist and European Specialist in Laboratory Medicine, Italy
  • Farhan Ahmad Khan Department of Pharmacology, Teerthanker Mahaveer Medical College and Research Centre, TMU, India,
  • Luca Cabianca Biomedical Laboratory, Italy
  • Mobin Ibne Mokbul Founder & President, International Light of Neuroscience Foundation House: 32/A, Road-03, Prianka Housing, Turag City, Mirpur-1, Dhaka-1216
  • Ahmed Yesvi Rafa Co-Founder & General Secretary, ILNF Independent Neuroscience Researcher, Independent Applied Physics Researcher, Dhaka, Bangladesh
  • Behzad Nili Ahmadabadi Nano Drug Delivery, Chapel Hill NC 27514, USA
Keywords: Amygdala activation level, Pharmacology Neuro Imaging, Antisocial personality disorder.


We don’t have today drugs specifically registered for amygdala dysfunctions as preventable agents towards some kind of crime behavior. This Neuro psychiatric condition or organ state are to be considered and treated in preventive way as common disease.

There is an amygdala physio-pathological Level of activation.  Still we are not sure to call this dysfunctions status as disease and drugs are needed or efficacy to control it. A neuro-pharmacology research of amygdala can give the response also using imaging Techniques. Studies demonstrated that Amygdala activation is involved in aggressive behavior. The aim of this work is to investigate in this relationship and to find if there is a level of activation.


Download data is not yet available.


1. Gregg TR1, Siegel A. et al. Brain structures and neurotransmitters regulating aggression in cats: implications for human aggression. Prog Neuropsychopharmacol Biol Psychiatry. 2001 Jan;25(1):91-140.
2. Fumagalli M, Priori A. Brain. Functional and clinical neuroanatomy of morality. 2012 Jul;135(Pt 7):2006-21. doi: 10.1093/brain/awr334. Epub 2012 Feb 13.
3. Klasen M, Zvyagintsev M, Schwenzer M, Mathiak KA, Sarkheil P, Weber R, et al. Quetiapine modulates functional connectivity in brain aggression networks. 2013 Jul 15;75:20-6. doi: 10.1016/j.neuroimage.2013.02.053. Epub 2013 Mar 7.
4. Patki G, Atrooz F, Alkadhi I, Solanki N, Salim S. High aggression in rats is associated with elevated stress, anxiety-like behavior, and altered catecholamine content in the brain. Neurosci Lett. 2015 Jan 1;584:308-13. doi: 10.1016/j.neulet.2014.10.051. Epub 2014 Nov 1.
5. Thijssen S1, Ringoot AP, Wildeboer A, Bakermans-Kranenburg MJ, El Marroun H, Hofman A, Jaddoe VW, et al. Brain morphology of childhood aggressive behavior: A multi-informant study in school-age children. Cogn Affect Behav Neurosci. 2015 Sep;15(3):564-77
6. Hayes JP, Hayes SM, Mikedis AM. Quantitative meta-analysis of neural activity in posttraumatic stress disorder. Biol Mood Anxiety Disord. 2012; 2: 9.
7. Sergerie K, Chochol C, Armony JL. The role of the amygdala in emotional processing: a quantitative meta-analysis of functional neuroimaging studies. Neurosci Biobehav Rev. 2008;32(4):811-30. doi: 10.1016/j.neubiorev.2007.12.002. Epub 2008 Jan 17.
8. Blair RJ1, Morris JS, Frith CD, Perrett DI, Dolan RJ. Dissociable neural responses to facial expressions of sadness and anger. Brain. 1999 May;122 ( Pt 5):883-93.
9. R. JAMES R. Blair. Neurobiological basis of psychopathy. The British Journal of Psychiatry Jan 2003, 182 (1) 5-7; DOI: 10.1192/bjp.182.1.5
10. Raine A, Buchsbaum M, LaCasse L. Brain abnormalities in murderers indicated by positron emission tomography. Biol Psychiatry. 1997 Sep 15;42(6):495-508.
11. Hornak J, Rolls ET, Wade D. Face and voice expression identification in patients with emotional and behavioral changes following ventral frontal lobe damage. Neuropsychologia. 1996;34:247–61
12. Coccaro EF1, Lee R2, McCloskey M3, Csernansky JG4, Wang L5. J Morphometric analysis of amygdla and hippocampus shape in impulsively aggressive and healthy control subjects. Psychiatr Res. 2015 Oct;69:80-6.
13. Goodman et. al. Dialectical behavior therapy alters emotion regulation and amygdala activity in patients with borderline personality disorderPsychiatr Res. 2014 October; 57: 108–116.
14. Comai S1, Tau M, Gobbi G.J. The psychopharmacology of aggressive behavior: a translational approach: part 1: neurobiology. Clin Psychopharmacol. 2012 Feb;32(1):83-94
15. del casale et al. Functional Neuroimaging inPsychopathy. Neuropsychobiology 2015;72:97–117
How to Cite
Luisetto M, Khan FA, Cabianca L, Mokbul MI, Rafa AY, Ahmadabadi BN. Amygdala pharmacology and crime behavior, dysfunctions to be considered as a disease?. Int Arch BioMed Clin Res [Internet]. 2016Jun.18 [cited 2023Sep.26];2(2):1-. Available from: