Association of Human Papilloma Virus (HPV And Oral Cavity Squamous Cell Carcinoma (OSCC): Indian Scenario
DOI:
https://doi.org/10.21276/v6779d45Keywords:
Oral Cavity Squamous Cell Cancer, Human Papilloma Virus, Oropharyngeal cancerAbstract
Background: About 80-90% of HNSCC are associated with known risk factor e.g. smoking, tobacco chewing & alcohol abuse. The role of human papilloma virus (HPV) in the etiology of HNSCC has emerged in last few years. Many studies have proved HPV in oropharyngeal cancer but there are very few studies regarding role of HPV in oral cavity which constitutes the 90% of HNSCC. The purpose of this study was to look for the prevalence of HPV in HNSCC in India.
Method: This was a prospective observational study. 50 cases of suspected malignant ulcers of oral cavity were biopsied. Having confirmed the lesion as SCC, HPV 16 and 18 analysis was done on frozen samples by PCR. Results: The most common site of OSCC was oral tongue (50%). About 80% of the patients had some form of addiction. 36% of the patients had early stage disease whereas 64% had late stage disease with 76% cases of well differentiated SCC. Only 2 (4%) patients were found to be HPV positive. Conclusions: HPV is an important etiological agent in HNSCC in western patients but its role in OSCC has yet not been significant. In India, tobacco and alcohol are commonly identified etiological agents of HNSCC. The rarity of HPV might be due to the differences in the cultural and sexual behavior. Also, HPV vaccine is predicted to reduce the incidence of oral cancer due to HPV. However, further studies are required to label HPV as etiological factor for OSCC proper.
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Jemal A, Braf F, Center MM, et al. Global cancer statistics. Ca cancer j clin 2011; 61 - 90.
Molinolo AA, Amornphimoltham P, Squarize CH, Castilho RM, Patel V, Gutkind JS: Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol 2008.
Syrjänen S: Human papillomavirus (HPV) in head and neck cancer. J Clin Virol 2005; 32: 59-66.
Pande P, Soni S, Kaur J, Agarwal S, Mathur M, Shukla NK et al: Prognostic factors in betel and tobacco related oral cancer. Oral Oncol 2002; 38: 491-499.
Zavras AI, Douglass CW, Joshipura K et al. Smoking and alcohol in the etiology of oral cancer: gender-specific risk profiles in the south of Greece. Oral Oncol 2001; 37: 28–35.
Scully C: Oral squamous cell carcinoma; from an hypothesis about a virus, to concern about possible sexual transmission. Oral Oncol 2002; 38: 227-234.
Pande P, Soni S, Kaur J et al. Prognostic factors in betel and tobacco related oral cancer. Oral Oncol 2002; 38: 491–499.
Ramshankar V, Krishnamurthy A. Human Papilloma Virus in Head and Neck Cancers - Role and Relevance in Clinical Management. Indian J Surg Oncol 2013; 4(1): 59–66.
Lingen M, Sturgis EM, Kies MS. Squamous cell carcinoma of the head and neck in nonsmokers: Clinical and biologic characteristics and implications for management. Curr Opin Oncol 2001; 13: 176-82.
Zur Hausen H. Viruses in human cancer. Science 1991; 254: 1167-73.
Gillison ML, D’Souza G, Westra W et al. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 2008; 100(6): 407–20.
D’Souza G, Kreimer AR, Viscidi R et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007; 356(19): 1944–56.
Lingen MW, Xiao W, Schmitt A,Jiang B,Pickard R,Kreinbrink P et al. Low etiologic fraction for high-risk human papillomavirus in oral cavity squamous cell carcinomas. Oral Oncol 2013; 49: 1–8.
Ribeiro KB, Levi JE. Low human papillomavirus prevalence in head and neck cancer: results from two large case–control studies in high-incidence regions. Int Jour of Epidemio 2011; 40: 489–502.
Poling JS, Ma XJ, Bui S, Luo Y. Human papillomavirus (HPV) status of non-tobacco related squamous cell carcinomas of the lateral tongue. Oral Oncol 2014; 50: 306–10.
Liang XH, Lewis J, Foote R, Smith D, Kademani D. Prevalence and significance of human papillomavirus in oral tongue cancer: the mayo clinic experience. J Oral Maxil Surg 2008; 66: 1875–80.
Van Rensburg EJ, van Heerden WF, Venter EH, Raubenheimer EJ. Detection of human papillomavirus DNA with in situ hybridisation in oral squamous carcinoma in a rural black population. S Afr Med J 1995; 85: 894–96.
Sand L, Jalouli J, Larsson PA, Hirsch JM. Human papilloma viruses in oral lesions. Anticancer Res 2000; 20: 1183–88.
Smith EM, Ritchie JM, Summersgill KF, Klussmann JP, Lee JH, Wang D et al. Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int J Cancer 2004; 108:766-72.
Rivero ER, Nunes FD. HPV in oral squamous cell carcinomas of a Brazilian population: amplification by PCR. Pesqui Odontol Bras 2006; 20: 21–24.
Boy S, Van Rensburg EJ, Engelbrecht S et al. HPV detection in primary intraoral squamous cell carcinomas—commensal, aetiological agent or contamination? J Oral Pathol Med 2006; 35: 86–90.
Van Rensburg EJ ES, Van Heerden WF, Raubennheimer EJ, Schoub BD. Human papillomavirus DNA in oral squamous cell carcinomas from an African population sample. Anticancer Res 1996; 16: 969–73.
Ibrahim SO, Bertelsen B, Kalvenes MB et al. Expression of keratin 13, 14 and 19 in oral squamous cell carcinomas from Sudanese snuff dippers: lack of association with human papillomavirus infection. Apmis 1998; 106: 959–69.
Jalouli J, Ibrahim SO, Mehrotra R et al. Prevalence of viral (HPV, EBV, HSV) infections in oral submucous fibrosis and oral cancer from India. Acta Otolaryngol 2010; 130: 1306–11.
Nagpal JK, Patnaik S, Das BR. Prevalence of high-risk human papilloma virus types and its association with P53 codon 72 polymorphism in tobacco addicted oral squamous cell carcinoma (OSCC) patients of Eastern India. Int J Cancer 2002; 10(97): 649–53.
Pillai MR, Phanidhara A, Kesari Al, Nair P, Nair MK. Cellular Manifestations of human papillomavirus infection in the oral mucosa. J Surg Oncol 1999; 71: 10–15.
Agrawal GP, Joshi P, Agrawal A. Role of HPV-16 in Pathogenesis of Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma and Correlation
of p 16INK4A Expression in HPV-16 Positive Cases: An Immunohistochemical Study. ISRN Pathology 2013; 1-7.
Barwad A, Sood S, Gupta N, Rajwanshi A, Panda N, Srinivasan R. Human Papilloma Virus Associated Head and Neck Cancer: A PCR Based Study. Diag Cytopath 2012; 40(10): 893 – 97.
McKaig RG, Baric RS, Olshan AF. Human papilloma virus and head and neck cancer: Epidemiology and molecular biology. Head Neck 1998; 20: 250–65.
Koppikar P, DeVilliers EM, Mulherkar R. Identification of human papillomaviruses in tumors of the oral cavity in an Indian community. Int J Cancer 2005; 113: 946–50.
Termine N, Panzarella V, Falaschini S, Russo A,Matranga D, Muzio L, Campisi G. HPV in oral squamous cell carcinoma vs head and neck squamous cell carcinoma biopsies: a meta-analysis(1988–2007). Annals of Oncology 2008; 19: 1681–90.
Kreimer AR, Clifford GM, Boyle P, Franceschi S. Human papillomavirus types inhead and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev 2005;14:467–75.
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