A Study to Assess Thrombocytopenia in High Risk Neonates in a Tertiary Care Hospital: A Prospective Observational Study
DOI:
https://doi.org/10.21276/sjqspr73Keywords:
Mild Thrombocytopenia, High Risk Neonates, Neonatal ThrombocytopeniaAbstract
Background: Thrombocytopenia is a significant cause of morbidity and mortality in high risk neonates. The present prospective observational study was conducted to assess incidence of thrombocytopenia in High Risk Neonates in a Tertiary Care Hospital.
Methods: This prospective observational study was carried out at Neonatal Intensive Care Unit (NICU) of a tertiary care hospital over a period of 6 months. A total of 140 high risk neonates (intramural + extramural) admitted to the NICU during this period formed the study group. Enrolled neonates were observed prospectively. Platelet count of less than 150,000/cu mm was taken as the cut off point for determining thrombocytopenia. Data was analyzed using SPSS version 22. P value less than 0.05 was considered significant.
Results: In the present study total high risk neonates were 140 in which 63.57% were males and 36.42% were females. The gestational age was normal in 50.71%, moderate to late preterm in 23.57%, very preterm in 17.85%, extreme preterm in 6.42% high risk neonates. The incidence of thrombocytopenia was 60.71% among the high risk neonates. Mild thrombocytopenia was observed in 16.47% neonates, moderate thrombocytopenia in 34.11% and severe thrombocytopenia in 49.41%.
Conclusions: Our study concluded that incidence of thrombocytopenia was 60.71% among the high-risk neonates. Mild thrombocytopenia was observed in 16.47% neonates, moderate thrombocytopenia in 34.11% and severe thrombocytopenia in 49.41%.
Downloads
References
Izak M, Bussel JB. Management of thrombocytopenia. F1000Prime Rep. 2014;6:45.
Veneri D, Franchini M, Randon F, Nichele I, Pizzolo G, Ambrosetti A. Thrombocytopenia: A clinical point of view. Blood Transfusion 2009; 7:75–85.
Bussel JB. Thrombocytopenia in newborns, infants and children. Pediatr Ann 1990; 19: 181- 5. 3.
Groves A, Kuschel C. NW Newborn Clinical Guideline: Neonatal Thrombocytopenia. Available from: http://www.adhb.govt.nz/newborn/guideline s/Blood/Platelets/NeonatalThrombocytopeni a.htm
McCrae KR. Thrombocytopenia in pregnancy. Hematology Am Soc Hematol Educ Program. 2010;2010:397–402.
Elvedi-Gasparovic V, Beljan P, Gveric-Ahmetasevic S, Schuster S, Škrablin S. Fetal-maternal complications and their association with gestational thrombocytopenia. Ginekol Pol. 2016;87(6):454–459.
Tiller H, Husebekk A, Ahlen MT, Stuge TB, Skogen B. Current perspectives on fetal and neonatal alloimmune thrombocytopenia—increasing clinical concerns and new treatment opportunities. Int J Womens Health. 2017;9:223–234.
Van den Akker ES, Oepkes D. Fetal and neonatal alloimmune thrombocytopenia. Best Pract Res Clin Obstet Gynaecol. 2008;22(1):3–14.
Roberts I, Murray NA. Neonatal thrombocytopenia. Semin Fetal Neonatal Med. 2008;13(4):256–264.
Roberts I, Murray NA. Neonatal thrombocytopenia: causes and management. Arch Dis Child Fetal Neonatal Ed. 2003;88(5):F359–F364.
Murray NA, Howarth LJ, McCloy MP, et al. Platelet transfusion in the management of severe thrombocytopenia in neonatal intensive care unit (NICU) patients. Transfusion Medicine 2002; 12:35–41. http://dx.doi.org/10.1046/j.13653148.2002.0 0343.x PMid: 11967135
Bhat YR, Cherian CS, Neonatal thrombocytopenia associated with maternal pregnancy induced hypertension, Indian Journal of Pediatrics 2008; 75(6):571-3. http://dx.doi.org/10.1007/s12098-008-0110- x PMid: 18759083
Castle V, Andrew M, Kelton J, Giron D, Johnston M, Carter C. Frequency and mechanism of neonatal thrombocytopenia. The Journal of pediatrics. 1986 May 1;108(5):749- 55.
Kyoung Hee Choi, Sung Soo Rim, Byung Min Moon, Ki Bok Kim. Study on platelet counts and indices in neonates; Korean J Pediatr (1996) March;39(3) :338-345.
Zaccheaus A Jeremiah, Justina E Oburu. Pattern and prevalence of neonatal thrombocytopenia in Port Harcourt, Nigeria; Pathol Lab Med Int. 2010:(2) 27–31.
Bolat F, Kılıç SÇ, Oflaz MB, et al. The prevalence and outcomes of thrombocytopenia in a neonatal intensive care unit: a three-year report. Pediatr Hematol Oncol. 2012;29(8):710–720.
Chakravorty S, Roberts I. How I manage neonatal thrombocytopenia. Br J Haematol. 2012;156(2):155–162.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 International Archives of BioMedical and Clinical Research (IABCR)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors are required to sign and submit the completed “Copyright transfer Form” upon acceptance of publication of the paper. This is determined by a publishing agreement between the author and International Archives of Biomedical and Clinical Research. These rights might include the right to publish, communicate and distribute online. Author(s) retain the copyright of their work. International Archives of Biomedical and Clinical Research supports the need for authors to share, disseminate and maximize the impact of their research.
