Causative Agents and Antimicrobial Sensitivity Pattern Among Patients of Urinary Tract Infection in a Tertiary Care Hospital of Western Uttar Pradesh

  • Amit Kumar Dept. of Pharmacology, FH Medical College & Hospital, Tundla
  • Shivangna Singh Dept. of Pharmacology, FH Medical College & Hospital, Tundla
  • Vivek Gautam PG 1st Year, Dept. of Medicine, SN Medical College, Agra.
  • Alka Yadav Dept. of Pharmacology, FH Medical College & Hospital, Tundla
  • Imran Zaheer Dept. of Pharmacology, FH Medical College & Hospital, Tundla
  • Praveen Agarwal Dept. of Pharmacology, FH Medical College & Hospital, Tundla
  • Priyamvada Sharma Dept. of Pharmacology, FH Medical College & Hospital, Tundla
Keywords: UTI, E.coli, Sensitivity, Resistance, Antimicrobials

Abstract

Background: UTI is one of the commonest domiciliary and nosocomial bacterial infection, especially affecting the females. Nowadays antibiotic resistance among uropathogens is an emerging problem in treatment of UTI. Periodic assessment of antimicrobial susceptibility among the microorganisms will be fruitful in treating UTI.  Aims:  To study and assess the sensitivity/resistance pattern among E.coli and other uropathogens for nitrofurantoin, ofloxacin, Cotrimoxazole & 3rd generation cephalosporins.

Methods: An observational, cross sectional study of 6 months duration from March 2016 to August 2016 was conducted on patients suffering from UTI in Department of Pharmacology and Department of Microbiology in FH Medical College & Hospital, Tundla, Uttar Pradesh. A total of 100 urine samples were analysed.

Results: E.coli was the predominant (46%) uropathogen followed by Klebsiella (27%), Proteus (12%), Staphylococcus (7%), Pseudomonas (5%) and Enterococcus (3%). UTI was more common among females (61%) and illiterates (62%). Nitrofurantoin was the most sensitive (58%) antimicrobial followed by ofloxacin (35%).

Conclusions: 3rd generation Cephalosporins showed higher percentage of resistance (78%).

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References

1. Bacterial disease. 8th edition. Frome and London: Butler and Tanler Ltd.1990; 197-214
2. Stamm WE, Norby SR. UTI: Diagnosis Panorama and Challenges. J Infect Dis. 2001; 183 (1): 1- 4.
3. Harrington RD, Hooton TM. Urinary tract infection risk factors and gender. Journal of Gend Specif Med. 2000; 3(8): 27-34
4. Ronald A. The etiology of urinary tract infection: Traditional and emerging pathogens. Am J Med. 2002; 113(1):14-19.
5. Shankel S. Urinary tract infections: Genitourinary disorders. The Merck Manuals Online Medical Library, 2007.
6. Perdue BE, Plaisance KI. Treatment of community acquired urinary tract infection, Am Pharm.1995; 35-37.
7. Alan J W. Volume 4, Campbell-Walsh urology. 9th ed. China: Saunders Elsevier, 2007.
8. Alper B, Curry S. Urinary Tract Infection in children. American family physician.2005; 72:12.
9. Warren JW, Abrutyn E, Hebel JR, Johnson JR, Schaeffer AJ, Stamm WE. Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women. Clin Infect Dis. 1999; 29: 745-58.
10. Jha N, Bapat SK. A study of sensitivity and resistance of pathogenic microorganism causing UTI in Kathmandu valley. Kath uni medi jour. 2005; 3(2): 123-29.
11. Sharma AR, Bhatta DR, Shrestha J, Banjara MR. Antimicrobial susceptibility pattern of Escherichia coli isolated from urinary tract infected patients attending Bir hospital, Nepal. J Sci Technol. 2013;14(1):177-84.
12. Thapa P, Parajuli K, Poudel A, Thapa A, Manadhar B, Laudari D, Malla HB, Katiwada R. Causative agents and susceptibility of antimicrobial among suspected female with urinary tract infection in tertiary care Hospital of western Nepal. Journ of chit med col. 2013; 3(4): 16-19.
13. Devmurari D, Kamal CM, Singh SN, Kumar A. Ofloxacin and Nitrofurantoin sensitivity pattern in patients of urinary tract infection at a tertiary care teaching hospital. Int arch of Biomed and clin res. 2015; 1(1): 17-22.
14. Bandyopadhyay D, Sarkar P, Biswas T. A Study of Antibacterial resistance of Urinary Tract isolates of Escherichia coli from burdwan Medical College West Bengal India. Reviews of progress.2013; 1(5): 2321-3484.
15. Nerurkar A, Solanky P, Naik S. Bacterial pathogens in urinary tract infection and antibiotics susceptibility pattern. Pharm Biomed Sci. 2012; 21:1-3.
16. Kattel H.P, Acharya J, Mishra AK, Rijal BP, Pokhrel BM. Bacteriology of urinary tract infection among patient attending Tribhuvan University Teaching Hospital Kathmandu Nepal. J. Nep. Asso. Med. Lab. Sci. 2008;9(1): 25-29.


17. Bashar MA, Ahmed MF, Rahman SR, Gomes DJ. Distribution and resistance trends of Escherichia coli from urinary tract infection isolated in Dhaka city. Bangladesh J. Med. Sci. 2009; 15(2): 93-98.
18. Jadhav S, Hussain A, Devi S, Kumar A, Praveen S, Gandham N, Wieler LH, Ewers CN. Ahmed N. Virulence characteristics and genetics affinities of multiple resistant uropathogenic Escherichia coli from a semi-urban locality in India. 2011; PLoS One 6(3):el8063.
Published
2016-12-28
How to Cite
1.
Kumar A, Singh S, Gautam V, Yadav A, Zaheer I, Agarwal P, Sharma P. Causative Agents and Antimicrobial Sensitivity Pattern Among Patients of Urinary Tract Infection in a Tertiary Care Hospital of Western Uttar Pradesh. Int Arch BioMed Clin Res [Internet]. 2016Dec.28 [cited 2019Dec.5];2(4):21-5. Available from: https://iabcr.org/index.php/iabcr/article/view/134
Section
ORIGINAL ARTICLES ~ General Surgery