Use of Nifedipine and Isoxpurine Hydrochloride in Prevention of Preterm Labor - A Prospective and Comparative Study
Abstract
Background: The study was done in Obstetric & Gynaecology Department of Dr. VRK Women's Medical college to prevent the preterm labor which one is better either Nifedipine or Isoxpurine hydrochloride.
Methods: In one month period total 1884 patients attended OPD of Obstetric & Gynaecology. Out of 416 patients came with preterm labor.200 patients chosen for tocolysis.100 patients were given Nifedipine and 100 patients Isoxpurine hydrochloride.
Results: Preterm labor incidence was 22% while preterm delivery incidence was 20.9%. Nifedipine was more effective than Isoxpurine hydrochloride for preterm labor whether it is diagnosed either in early stage or late stage. In early-diagnosed preterm labor, Nifedipine had higher efficacy than Isoxpurine (P value 6.45 × 10−6) and also higher efficacy than its own in late diagnosed preterm labor (P value 2.08 × 10−5).
Conclusions: In India preterm labor incidence is very high. So Nifedipine is better option than Isoxpurine hydrochloride especially when patient is having early signs of preterm labor.
Downloads
References
2. Begum F, Buckshee K, Pande JN. Risk factors associated with preterm labor. Bangladesh Med Ras Coune Bull. 2003;29:59-66. [PubMed]
3. Bibby E, Stewart A. The epidemiology of preterm birth. Neuro Endocrinol Lett. 2004;25:43-47. [PubMed]
4. Shingairai AF, Siaban DH, Godfrey BW. Risk factors for prematurity at Harare maternity hospital, Zimbabwe. Int J Epidemiol. 2004;33:1194-1201. doi: 10.1093/ije/dyh120. [PubMed] [Cross Ref]
5. King JF, Flenady VJ, Papatsonis DNM et al. Calcium channel blockers for inhibiting preterm labor (cochrane review). The cochrane library. Chichester: Wiley; 2004.
6. RCOG. Tocolytic drugs for women in preterm labor. In: Clinical guideline no. I (B). London: RCOG Press; 2002.
Copyright (c) 2017 International Archives of BioMedical and Clinical Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
2.png)
International Archives of BioMedical and Clinical Research (IABCR)
