A Hospital Based Prospective Study to Evaluate the Relationship of Micro Vascular and Macro Vascular Complications with Magnesium Levels in Patients with DM-2

Authors

  • Manish Kumar Singhal Assistant Professor Author
  • Arun Gaur Professor & Head, Department of Medicine, Government (RVRS) Medical College & Associate Groups of Mahatma Gandhi Hospital, Bhilwara, Rajasthan, India. Author

DOI:

https://doi.org/10.21276/81hd6a80

Keywords:

Hypomagnesaemia, Type 2 DM, HbA1c level, Microvascular, Macrovascular, Complications

Abstract

Background:Micronutrients have been explored as a probably preventive and curative agents for T2DM and their complexity. Not all studies, however, observed a correlation between glycemic control and serum magnesium levels or improvement of diabetic control with magnesium replacement.

Methods: A hospital based prospective study was done on 30 patients with DM type 2 attending medicine OPD and admitted in Government (RVRS) Medical College, Bhilwara were taken as cases also of Age group above 30 years. Presence of diabetes mellitus was defined as per Indian Diabetes Federation [IDF] Criteria and Dyslipidemia as per NCEP ATP III and IDF guidelines.

Results: In this study the commonest age group for type 2 DM was more than 41-60 years which comprised of 63.33% of the patients. The male to female ration was 3:1. The mean serum magnesium levels in patients with HbA1c levels ≥ 9.5% were significantly low (1.559±0.389 mg/dL) compared to patient with HbA1c levels 6.5 to 6.99% (1.622 ± 0.591mg/dL). This difference was statistically non significant (p>0.05).

Conclusion: Our study suggested that hypomagnesemia is widely prevalent in patients with type 2 diabetes mellitus and also related with poor glycaemic control and longer duration of diabetes.

Downloads

Download data is not yet available.

References

Wild S,Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care,2004;27:1047-53.

WHO Expert Committee on Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications, Geneva,1999:1-59.

Guidance for Industry, Diabetes Mellitus: Developing Drugs and Therapeutic Biologics for Treatment and Prevention, U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER). 2008:3.

Global burden of diabetes. International Diabetes federation. Diabetic atlas fifth edition 201, Brussels.

DMICC. Genetic basis of type 1 and type 2 diabetes, obesity, and their complications. Advances and emerging opportunities in diabetes research: a Strategic Planning report of the DMICC,2014.

Central Intelligence Agency (2008) The World Fact book: CIA.

Yach D, Hawkes C, Gould CL, Hofman KJ. The global burden of chronic diseases: overcoming impediments to prevention and control. JAMA,2014;291:2616-22.

IDF Diabetes Atlas. 4th ed., Brusels: International Diabetes Federation; 2009.

McNair P, Christensen MS, Christiansen C, Madsbad S, Transbol I: Renal hypomagnesaemia in human diabetes mellitus: Its relation to glucose homeostasis. Eur J Clin Invest 1982;12:81-5.

Voets T, Nilius B, Hoefs S, van der Kemp AW, Droogmans G, Bindels RJ, Hoenderop JG: TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem 2004;279:19–25.

Patil RS, Gothankar JS. Prevalence of Type-2 Diabetes Mellitus and Associated Risk Factors in an Urban Slum of Pune City, India. Natl J Med Res 2013;3(4):346-9.

Nadler JC, Rude RK. Disorders of magnesium metabolism. Endocrinol Metab Clinic North Am 1995;24:623-41.

Dasgupta A, Sarma D, Saikia UK. Hypomagnesemia in type 2 diabetes mellitus. Indian J EndocrMetab2012;16:1000-3.

Sakaguchi Y, Shoji T, Hayashi T, Suzuki A, Shimizu M, Mitsumoto K, et al. Hypomagnesemia in Type 2 Diabetic Nephropathy. Diabetes Care 2012;35:1591–7.

Abdul Wahid, Girish C. Verma, C. P. Meena, A. R. Pathan. Study of serum magnesium level in patients with type 2 diabetes mellitus and it’s correlation with glycosylated hemoglobin and diabetic complications. Int J Adv Med. 2017 Apr;4(2):311-316.

Downloads

Published

09.03.2024

Issue

Section

ORIGINAL ARTICLES ~ General Medicine

Similar Articles

1-10 of 268

You may also start an advanced similarity search for this article.