Assessment of Salivary Glucose Levels as a Metabolic Control Marker in Patients with Type 2 diabetes

Authors

  • Jaseetha S 1Assistant Professor, Department of Otolaryngology, PGIMSR and ESIC Model Hospital, Basaidarapur, New Delhi.110015 Author
  • Mayank Hans Assistant Professor, Department of Dentistry, ESIC Medical College & Hospital, Faridabad. Author

DOI:

https://doi.org/10.21276/vns40390

Keywords:

Glucose Levels, Salivary glands

Abstract

Background:Diabetes mellitus comprise of a group of metabolic diseases which is characterized by chronic hyperglycaemia consequential from defects in insulin secretion, insulin action, or both. This study aimed to determine any alterations in the salivary glucose levels and to assess for a correlation between salivary glucose levels and blood glucose levels in both diabetic and non-diabetic patients.

Methods: 100 diabetics and 100 non-diabetic aged matched healthy control were included into the study. Unstimulated saliva and blood samples were obtained from all subjects. Every sample was analysed for glucose straightaway or stored at –20°C in case of delay in analysis. Before evaluating, the saliva samples were centrifuged at 3500 rpm for 5 minutes, and resulting supernatant was assessed for presence of glucose. Data collected was analysed using statistical software. A p value of < 0.05 was taken as significant.

Results: Mean serum glucose (220.8 ± 66.64) and mean salivary glucose (8.94 ± 3.52) in the diabetics were higher than the mean serum glucose (91.63 ± 12.96) and mean salivary glucose (4.53± 2.56) in the non-diabetic group and the difference was highly significant (p< .001). A highly significant correlation existed between serum and salivary glucose levels in both diabetics and non-diabetics when assessed through Spearman’s Correlation coefficient (R = 0.70016 and the two-tailed value of P was 0 [highly significant]).

Conclusion: The salivary glucose levels of diabetics are significantly higher than the non-diabetics and the salivary glucose levels are correlated significantly with blood glucose levels. Thus, saliva could act as a potential non-invasive adjunct to monitor glycemic control in diabetic patients.

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References

American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2019. Diabetes Care 2019;42:S13-S28.

Dickens LT, Thomas CC. Updates in Gestational Diabetes Prevalence, Treatment, and Health Policy. Curr Diab Rep 2019;19:33.

Kaveeshwar SA, Cornwall J. The current state of diabetes mellitus in India. Australas Med J 2014;7:45-8.

Liang G, Jiang H, Huang C, Que X, Tang J, Lu J, Gao J. Diabetes health management strategy based on internet plus graded diagnosis and treatment strategy. Ann Palliat Med 2020;9:3915-3922.

Little RR, Goldstein DE. Endocrine (standardization of glycohemoglobin measurement). Anal Chem 1995;67:393R-397R.

Simmons JH, McFann KK, Brown AC, Rewers A, Follansbee D, Temple-Trujillo RE, Klingensmith GJ. Reliability of the Diabetes Fear of Injecting and Self-Testing Questionnaire in pediatric patients with type 1 diabetes. Diabetes Care 2007;30:987-8.

Wright S, Yelland M, Heathcote K, Ng SK, Wright G. Fear of needles-nature and prevalence in general practice. Aust Fam Physician. 2009;38:172-6.

Pfaffe T, Cooper-White J, Beyerlein P, Kostner K., Punyadeera C. Diagnostic potential of saliva: current state and future applications. Clin Chem. 2011;57:675-87.

Gröschl M. The physiological role of hormones in saliva. Bioessays2009;31:843-52.

Haeckel R., Hanecke P. The application of saliva, sweat and tear fluid for diagnostic purposes. Ann Biol Clin (Paris) 1993;51:903-10.

Lima DP, Diniz DG, Moimaz SAS, Sumida DH, Okamoto AC. Saliva: reflection of the body. Intl J Infect Diseases 2010;14:e184-8.

Chiappin S, Antonelli G, Gatti R, De Palo EF. Saliva specimen: a new laboratory tool for diagnostic and basic investigation. Clin Chim Acta 2007;383:30-40.

Chiasson JL, Morrisset R, Hamet P. Precision and costs of techniques for self-monitoring of serum glucose levels. Can Med Assoc J 1984;130:38-43

Lopez ME, Colloca ME, Paez RG, Schallmach JN, Koss MA, Chervonagura A. Salivary characteristics of diabetic children. Braz Dent J 2003;14:26-31.

Wou C, Unwin N, Huang Y, Roglic G. Implications of the growing burden of diabetes for premature cardiovascular disease mortality and the attainment of the Sustainable Development Goal target 3.4. Cardiovasc Diagn Ther2019;9:140-9.

Majidi S, Driscoll KA, Raymond JK. Anxiety in children and adolescents with type 1 diabetes. Curr Diab Rep 2015;15:47.

Bhattacharyya A, Chandra S, Singh A, Raj V, Gupta B. Salivary glucose levels and oral candidal carriage in Type 2 diabetics. J Oral BiolCraniofac Res 2018;8:158-64.

Uppu K, Sahana S, Madu GP, Vasa AA, Nalluri S, Raghavendra KJ. Estimation of Salivary Glucose, Calcium, Phosphorus, Alkaline Phosphatase, and Immunoglobulin A among Diabetic and Nondiabetic Children: A Case-Control Study. Int J Clin Pediatr Dent 2018;11:71-8.

Gupta S, Nayak MT, Sunitha JD, Dawar G, Sinha N, Rallan NS. Correlation of salivary glucose level with blood glucose level in diabetes mellitus. J Oral MaxillofacPathol2017;21:334-9.

Gupta S, Sandhu SV, Bansal H, Sharma D. Comparison of salivary and serum glucose levels in diabetic patients. J Diabetes Sci Technol2015;9:91-6.

BakianianVaziri P, Vahedi M, Mortazavi H, Abdollahzadeh SH, Hajilooi M. Evaluation of salivary glucose, IgA and flow rate in diabetic patients: a case-control study. J Dent (Tehran) 2010;7:13-8.

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Published

09.03.2024

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Section

ORIGINAL ARTICLES ~ OtoRhinoLaryngology

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