To Evaluate the Effect of Deep Breathing in Non-Diabetic Offsprings of Type 2 Diabetic Patients
DOI:
https://doi.org/10.21276/dwh50n08Keywords:
Diabetic mellitus, Yoga, hyperglycemiaAbstract
Background: Type 2 diabetes mellitus (DM) has a strong genetic component. Individuals of a parent with type 2 DM have an increased (40%) risk of diabetes. If both parents have type 2 DM, the risk approaches to 70%. Thus, this study was designed to evaluate cardiovascular parasympathetic functions in offsprings of type 2 diabetic parents.
Methods: This study was conducted in Department of Physiology, United Institute Of Medical Sciences, Allahabad, UP. This study was conducted over a period of one year. This study we were included 50 cases, who are healthy but they were having parental history of type-2 diabetic mellitus & 50 healthy controls who are healthy as well as their parent also do not have such type of any diabetic history.
Results: The result of this study revealed that Study showed decrease in all the three parasympathetic function tests (heart rate variability in response to deep breathing, heart rate variation in response to standing, and valsalva maneuver) in offsprings of type 2 diabetic parents (cases) as compared to non-diabetic parents (controls). However, the results were not statistically significant.
Conclusion: These findings can be utilized to prevent future cardiovascular risk in subjects by non-pharmacological means as exercise and yoga.
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References
Jali MV, Kambar S. Prevalence of diabetes amongst the family members of known diabetics. Int J Diab Dev Ctries. 2006;26(2):81–85.
Ramachandaran A. Type 2 diabetes in South Asians: Epidemiology, risk factors and prevention: In: Mohan V, Rao HRG, editors.1 ed : Jaypee brothers; 2007.p.1-39.
Raman PG. Diabetes mellitus. 3ed: A.I.T.B.S publishers New delhi; p.1-5.
Tiwari AK, Rao JM. Diabetes mellitus and multiple therapeutic approaches of phytochemicals : Present status and future prospects. Current science. 2002;83(1):30-8.
Visceral control mechanism: Visceromotor and autonomic nervous system.In:Tandon OP, Tripathi Y.editors.Best and taylors Physiological basis of medical practice.13 ed. Wolters Kluver. p1154-62.
Ganong WF. Review of medical physiology. 23rd ed. McGraw-Hill; 2010. 315-322.
Alwin C. Diabetes mellitus.In :C Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J. editors. Harrison's principles of internal medicine. 18 ed.NY: McGraw hill; 2012. p.2968-3009.
Davidson’s principles & practice of medicine.21st ed. Churchill Livingstone, Elsevier 2010. 795–834.
Diabtes mellitus and other disorders of metabolism. In: Kumar P, Clark M.editors.Kumar and Clarks clinical medicine. 7ed. Elsevier.p.1029-59.
Zafar U, Qureshi HJ, Sandhu QS, Ali Z. Frequency and association of family history of type 2 diabetes mellitus in type 2 diabetic patients. Pak J med health sci. 2013;7:1-3.
Mahanta BN, Mahnta TM. Clinical profile of persons with family history of diabetes mellitus with special reference to body fat percentage. J Assoc Physicians India. 2009;57:703-5.
Ramachandran A, Snehalatha C, Sivasankari S, Hitman GA, Vijay V. Parental influence on the spectrum of type 2 diabetes in the offspring among Indians. J Assoc Physicians India. 2007 Aug;55:560-2
Kaprio J, Tuomilehto J, Koskenvuo M, Romanov K, Reunanen A, Eriksson J, et al. Concordance for type 1 (insulindependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia. 1992;35(11):1060-7.
Groop L, Forsblom C, Lehtovirta M, Tuomi T, Karanko S, Nissén M, et al. Metabolic consequences of a family history of NIDDM (the Botnia study): Evidence for sex-specific parental effects. Diabetes. 1996;45(11):1585-93.
Ewing DJ, Clarke BF: Diagnosis and management of diabetic autonomic neuropathy. Br Med J (Clin Res Ed). 285:916-918, 1982
Pal GK, Pal P (2010) Autonomic function tests. In: Textbook of Practical Physiology. Chennai: Universities Press. pp. 282–290.
Barkai L, Madacsy L. Cardiovascular autonomic dysfunction in diabetes mellitus. Arch Dis Child 1995;73(6):515-8
Pal G K , Pravati Pal, Nivedita Nanda, Venugopal Lalitha, Avupati Naga Syamsunder, Kuppusamy Saranya, Jagadeeswaran Indumathy, Allampalli Sirisha Decreased Baroreceptor Reflex Sensitivity in First-degree Relatives of Type 2 Diabetics is Linked to Sympathovagal Imbalance and Cardiovascular Risks , Journal of Cardiovascular Disease Research Vol 5 Issue 2 Apr-Jun 2014 43
Das Piyali, Neogi Aniruddha, Biswas Subhradeb, Bhattacharjee Debojyoti, Bandyopadhyay Manimay. Indian Medical Gazette. 2013 Aug ; 147 (8): 302-305.
Rodriguez-Moran M, Guerrero-Romero F. e parental phenotype of diabetes, but not of essential hypertension, is linked to the development of metabolic syndrome in Mexican individuals.Acta Diabetologica 2001;38:87–91
Scherrer U, Sartori C. Insulin as a vascular and sympatho excitatory hormone: implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity. Circulation 1997; 96: 4104-4113
Philippe Van De Borne1, Martin Hausberg1, Robert P. Hoffman ,Allyn L Mark, ErlingA Anderson. Hyperinsulinemia produces cardiac vagal withdrawal and nonuniform sympathetic activation in normal subjects. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 1999;276:178183. RodriguezMoran M, Guerrero-Romero F. e parental phenotype of diabetes, but not of essential hypertension, is linked to the development of metabolic syndrome in Mexican individuals.Acta Diabetologica 2001;38:87–91.
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