Use of Nifedipine and Isoxpurine Hydrochloride in Prevention of Preterm Labor - A Prospective and Comparative Study

Authors

  • Manju Kumari Professor, Department of Obstetrics and Gynaecology, Mahavir Institute of Medical Sciences, Vikarabad, R. R Dist. Author

DOI:

https://doi.org/10.21276/0fj39m69

Keywords:

Uterine contractions, Betamethasone, prematurity, nifedepine, isoxpurine, preterm labor

Abstract

Background: The study was done in Obstetric & Gynaecology   Department of Dr. VRK Women's Medical college to prevent the preterm labor which one is better either Nifedipine or Isoxpurine hydrochloride.

Methods: In one month period total 1884 patients  attended OPD of Obstetric & Gynaecology. Out of 416 patients came with preterm labor.200 patients chosen for tocolysis.100 patients were given Nifedipine and 100 patients Isoxpurine hydrochloride.

Results: Preterm labor incidence was 22% while preterm delivery incidence was 20.9%. Nifedipine was more effective than Isoxpurine hydrochloride for preterm labor whether it is diagnosed either in early stage or late stage. In early-diagnosed preterm labor, Nifedipine had higher efficacy than Isoxpurine (P value 6.45 × 10−6) and also higher efficacy than its own in late diagnosed preterm labor (P value 2.08 × 10−5).

Conclusions: In  India preterm labor incidence is very high. So Nifedipine is better option than Isoxpurine hydrochloride especially when patient is having early signs of preterm labor.

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References

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Shingairai AF, Siaban DH, Godfrey BW. Risk factors for prematurity at Harare maternity hospital, Zimbabwe. Int J Epidemiol. 2004;33:1194-1201. doi: 10.1093/ije/dyh120. [PubMed] [Cross Ref]

King JF, Flenady VJ, Papatsonis DNM et al. Calcium channel blockers for inhibiting preterm labor (cochrane review). The cochrane library. Chichester: Wiley; 2004.

RCOG. Tocolytic drugs for women in preterm labor. In: Clinical guideline no. I (B). London: RCOG Press; 2002.

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Published

07.04.2024

Issue

Section

ORIGINAL ARTICLES ~ General Surgery

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