Evaluate an Association Between Isotretinoin and Depression in Acne Patients: An Open Labelled Prospective Study

  • Shafia Nisar Kakroo Assistant Professor, Department of Dermatology, Venerology and Leprosy, Hamdard Institute of Medical Sciences and Research, Delhi, India
  • Mirza Aumir Beg Consultant Dentist, Health & Welfare department
  • Basit Kakroo Final year Medical Student, Norwich Medical school, University of east Angila, UK
  • Md Ashraf Jamal Senior Resident, Department of Dermatology, Venerology and Leprosy, Hamdard Institute of Medical Sciences and Research, Delhi, India
Keywords: Acne, isotretinoin, depression.

Abstract

Background: Acne vulgaris is a multifactorial disease in which there are abnormalities in follicular keratinization, sebum production, proliferation of Propionibacterium and inflammation. It is a common disorder among young adults causing a considerable psychological impact. Treatment options include topical comedolytics, topical and systemic antibiotics, hormonal manipulations, and oral retinoids.  Isotretinoin is a synthetic oral retinoid that is very effective in the treatment of moderate to severe acne. But there have been many reports associating isotretinoin with depression, though no clear evidence has been established. Aim: To determine whether oral isotretinoin increases the risk of depression in patients with acne.

Methods: 160 patients, with moderate to severe acne were treated with oral isotretinoin 0.5 mg/kg/day for a period of 3 months. Their acne and depression scoring was done at baseline and then every month for the first 3 months and then at 6 months.

Results: It was found that the acne scoring reduced from 4.10 ± 0.47 to 0.60 ± 0.61 (P = < 0.001) at the end of 3 months. There was a significant decrease in depression score from 4.89 ± 4.8 to 0.42 ± 1.12 (P < 0.001) at the end of 3 months. Both the acne and depression scores continued to remain low at the end of 6 months at 0.5 ± 0.52 and 0.18 ± 0.51, respectively.

Conclusions: This study concluded, that oral isotretinoin shows effective results in acne. Our study revealed no association between depression and isotretinoin but showed significant reduction in depression scores.

 

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Author Biographies

Mirza Aumir Beg, Consultant Dentist, Health & Welfare department

 

 

Basit Kakroo, Final year Medical Student, Norwich Medical school, University of east Angila, UK

 

 

Md Ashraf Jamal, Senior Resident, Department of Dermatology, Venerology and Leprosy, Hamdard Institute of Medical Sciences and Research, Delhi, India

 

 

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Published
2020-09-30
How to Cite
1.
Kakroo SN, Beg MA, Kakroo B, Jamal MA. Evaluate an Association Between Isotretinoin and Depression in Acne Patients: An Open Labelled Prospective Study. Int Arch BioMed Clin Res [Internet]. 2020Sep.30 [cited 2020Oct.21];6(3):SD9-SD11. Available from: http://iabcr.org/index.php/iabcr/article/view/620
Section
ORIGINAL ARTICLES ~ Skin & VD